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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
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| Preferred Name | spirapril | |
| Synonyms |
C22H30N2O5S2 (8S)-7-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid |
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| ID |
http://purl.obolibrary.org/obo/dinto_DB01348 |
|
| ATCCode |
C09AA11
|
|
| binds |
http://purl.obolibrary.org/obo/dinto_2130 |
|
| CASRN |
83647-97-6
|
|
| DBBrand |
renormax
|
|
| Definition |
Spirapril is an ACE inhibitor antihypertensive drug used to treat hypertension. Like many ACE inhibitors, this is a prodrug which is converted to the active metabolite spiraprilat following oral administration. ACE inhibitors are used primarily in treatment of hypertension and congestive heart failure.
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| has pharmacological target | ||
| InChI |
InChI=1S/C22H30N2O5S2/c1-3-29-21(28)17(10-9-16-7-5-4-6-8-16)23-15(2)19(25)24-14-22(30-11-12-31-22)13-18(24)20(26)27/h4-8,15,17-18,23H,3,9-14H2,1-2H3,(H,26,27)/t15-,17-,18-/m0/s1
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|
| InChIKey |
InChIKey=HRWCVUIFMSZDJS-SZMVWBNQSA-N
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|
| inhibits | ||
| is substrate of | ||
| is transported by | ||
| label |
spirapril
|
|
| may interact with |
http://purl.obolibrary.org/obo/dinto_DB00384 http://purl.obolibrary.org/obo/dinto_DB01356 http://purl.obolibrary.org/obo/CHEBI_63629 |
|
| prefixIRI |
obo2:dinto_DB01348
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|
| prefLabel |
spirapril
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|
| SMILES |
CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@@H](C)C(=O)N1CC2(C[C@H]1C(O)=O)SCCS2
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|
| Synonym |
C22H30N2O5S2 (8S)-7-[(2S)-2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl]-1,4-dithia-7-azaspiro[4.4]nonane-8-carboxylic acid
|
|
| xref |
Wikipedia:http://en.wikipedia.org/wiki/Spirapril PubChem Compound:5311447 PubChem Substance:46506126 ChemSpider:4470933 BindingDB:50017124 PharmGKB:PA164776913
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| subClassOf |
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