The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
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Preferred Name

cilazapril
Synonyms

(1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxo-octahydro-1H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid

C22H31N3O5
ID

http://purl.obolibrary.org/obo/dinto_DB01340
AHFScode

24:32.04
ATCCode

C09AA08
binds

http://purl.obolibrary.org/obo/dinto_1440

http://purl.obolibrary.org/obo/dinto_2130

http://purl.obolibrary.org/obo/dinto_4065

http://purl.obolibrary.org/obo/dinto_2004
CASRN

92077-78-6
DBSynonym

inhibace
Definition

One of the angiotensin-converting enzyme inhibitors (ACE inhibitors) used for hypertension. It is a prodrug that is hydrolyzed after absorption to its main metabolite cilazaprilat. [PubChem]
has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0001297

http://purl.obolibrary.org/obo/OAE_0000449

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0001373

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000902

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0000218

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000479

http://purl.obolibrary.org/obo/OAE_0000659

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0000561

http://purl.obolibrary.org/obo/OAE_0001046

http://purl.obolibrary.org/obo/OAE_0000900

http://purl.obolibrary.org/obo/OAE_0000921

http://purl.obolibrary.org/obo/OAE_0000308

http://purl.obolibrary.org/obo/OAE_0001360

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0000415

http://purl.obolibrary.org/obo/OAE_0000195

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000210

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0000317

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0000197

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000050

http://purl.obolibrary.org/obo/OAE_0001365

http://purl.obolibrary.org/obo/OAE_0000476

http://purl.obolibrary.org/obo/OAE_0000770

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0001463

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0000551

http://purl.obolibrary.org/obo/OAE_0000455

http://purl.obolibrary.org/obo/OAE_0000084

http://purl.obolibrary.org/obo/OAE_0001200

http://purl.obolibrary.org/obo/OAE_0000268

http://purl.obolibrary.org/obo/OAE_0000400

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0000510

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000542

http://purl.obolibrary.org/obo/OAE_0000607

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000038

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0002122

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0001356

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000487

http://purl.obolibrary.org/obo/OAE_0001217

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000346

http://purl.obolibrary.org/obo/OAE_0000462

http://purl.obolibrary.org/obo/OAE_0001309

http://purl.obolibrary.org/obo/OAE_0001366

http://purl.obolibrary.org/obo/OAE_0000534

http://purl.obolibrary.org/obo/OAE_0000480

http://purl.obolibrary.org/obo/OAE_0001364

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target

http://purl.obolibrary.org/obo/dinto_2130
InChI

InChI=1S/C22H31N3O5/c1-2-30-22(29)18(13-12-16-8-4-3-5-9-16)23-17-10-6-14-24-15-7-11-19(21(27)28)25(24)20(17)26/h3-5,8-9,17-19,23H,2,6-7,10-15H2,1H3,(H,27,28)/t17-,18-,19-/m0/s1
InChIKey

InChIKey=HHHKFGXWKKUNCY-FHWLQOOXSA-N
inhibits

http://purl.obolibrary.org/obo/dinto_1440

http://purl.obolibrary.org/obo/dinto_2130
is substrate of

http://purl.obolibrary.org/obo/dinto_4065

http://purl.obolibrary.org/obo/dinto_2004
is transported by

http://purl.obolibrary.org/obo/dinto_4065

http://purl.obolibrary.org/obo/dinto_2004
label

cilazapril
may interact with

http://purl.obolibrary.org/obo/dinto_DB00384

http://purl.obolibrary.org/obo/CHEBI_50838

http://purl.obolibrary.org/obo/CHEBI_9241

http://purl.obolibrary.org/obo/dinto_DB01356

http://purl.obolibrary.org/obo/CHEBI_50861

http://purl.obolibrary.org/obo/CHEBI_63629

http://purl.obolibrary.org/obo/CHEBI_2639

http://purl.obolibrary.org/obo/dinto_DB01345
prefixIRI

obo2:dinto_DB01340
prefLabel

cilazapril
SMILES

CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]1CCCN2CCC[C@H](N2C1=O)C(O)=O
Synonym

(1S,9S)-9-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxo-octahydro-1H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid

C22H31N3O5
xref

Drugs Product Database (DPD):1911465

Wikipedia:http://en.wikipedia.org/wiki/Cilazapril

PharmGKB:PA164748302
subClassOf

http://purl.obolibrary.org/obo/dinto_000055
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Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_3698 DRON LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000171771 NDFRT LOOM
http://purl.jp/bio/4/id/200906015031969127 IOBC LOOM
http://stirdf.jst.go.jp/id/200907051476840396 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0055723 OCHV LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018317 PMAPP-PMO LOOM
http://www.co-ode.org/ontologies/galen#Cilazapril GALEN LOOM
http://purl.obolibrary.org/obo/CHEBI_3698 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_3698 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_3698 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3698 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_3698 DDSS LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.710.100 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D017315 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB01340 FTC LOOM
http://purl.obolibrary.org/obo/MESH_D017315 BERO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/395947008 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/XCO_0000592 XCO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#13747 OCHV LOOM
http://purl.bioontology.org/ontology/MESH/D017315 MESH LOOM
http://purl.bioontology.org/ontology/NDDF/003950 NDDF LOOM
http://purl.bioontology.org/ontology/RCD/bi8.. RCD LOOM
https://go.drugbank.com/drugs/DB01340 MDM LOOM
http://purl.bioontology.org/ontology/RXNORM/21102 RXNORM LOOM
http://purl.obolibrary.org/obo/OMIT_0017691 OMIT LOOM
http://purl.bioontology.org/ontology/ATC/C09AA08 ATC LOOM
http://purl.bioontology.org/ontology/VANDF/4025239 VANDF LOOM