The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

aminophylline
Synonyms

C16H24N10O4

bis(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione); ethane-1,2-diamine

ID

http://purl.obolibrary.org/obo/dinto_DB01223

AHFScode

86:16.00

ATCCode

R03DA05

binds

http://purl.obolibrary.org/obo/dinto_1014

http://purl.obolibrary.org/obo/dinto_3000

http://purl.obolibrary.org/obo/dinto_1538

http://purl.obolibrary.org/obo/dinto_0932

http://purl.obolibrary.org/obo/dinto_2651

http://purl.obolibrary.org/obo/dinto_0293

http://purl.obolibrary.org/obo/dinto_0901

blocks

http://purl.obolibrary.org/obo/dinto_1538

http://purl.obolibrary.org/obo/dinto_0932

CASRN

317-34-0

DBBrand

diaphylline

theophyline ethylenediamine

rectalad-aminophylline

rectalad aminophylline

ethophylline

carena

cariomin

variaphylline

etilen-xantisan tabl.

euufillin

methophylline

miofilin

truphylline

cardiomin

eurphyllin

diophllin

theolone

theophyllaminum

aminocardol

phyllocontin

somophyllin o

ammophyllin

dobo

metaphylline

cardophyllin

theophyllin ethylenediamine

thephyldine

diuxanthine

syntophyllin

theolamine

grifomin

cardophylin

theophyllamine

neophyiline

norofilina

phylcardin

theophyldine

phyllindon

vasofilina

minaphil

somophyllin

dura-tab s.m. aminophylline

theophylline ethylenediamine

genophyllin

lixaminol

somophyllin-o

stenovasan

metaphyllin

phyllocontin-350

linampheta

theophyllin aethylendiamin

cardiofilina

lasodex

inophylline

aminodur

peterphyllin

theodrox

DBSynonym

aminophylline dihydrate

aminophyllin

aminophylline anhydrous

aminophylline dye free

Definition

Aminophylline is a drug combination that contains theophylline and ethylenediamine in a 2:1 ratio. Once in the body, theophylline is released and acts as a phosphodiesterase inhibitor, adenosine receptor blocker, and histone deacetylase activator. Similar to other theophyllines, aminophylline is indicated for the treatment of lung diseases such as asthma, chronic bronchitis, and COPD. The majority of aminophylline medications are discontinued and the remaining medications on the market are in short supply.

has effect

http://purl.obolibrary.org/obo/OAE_0000817

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0001437

http://purl.obolibrary.org/obo/OAE_0000659

http://purl.obolibrary.org/obo/OAE_0000617

http://purl.obolibrary.org/obo/OAE_0001393

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0001378

http://purl.obolibrary.org/obo/OAE_0000632

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000551

http://purl.obolibrary.org/obo/OAE_0001105

http://purl.obolibrary.org/obo/OAE_0001003

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0001742

http://purl.obolibrary.org/obo/OAE_0000866

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000881

http://purl.obolibrary.org/obo/OAE_0000402

has pharmacological target

http://purl.obolibrary.org/obo/dinto_1538

http://purl.obolibrary.org/obo/dinto_1014

http://purl.obolibrary.org/obo/dinto_0932

http://purl.obolibrary.org/obo/dinto_3000

InChI

InChI=1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2

InChIKey

InChIKey=FQPFAHBPWDRTLU-UHFFFAOYSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_1014

is metabolised by

http://purl.obolibrary.org/obo/dinto_2651

http://purl.obolibrary.org/obo/dinto_0293

http://purl.obolibrary.org/obo/dinto_0901

is substrate of

http://purl.obolibrary.org/obo/dinto_2651

http://purl.obolibrary.org/obo/dinto_0293

http://purl.obolibrary.org/obo/dinto_0901

label

aminophylline

may interact with

http://purl.obolibrary.org/obo/CHEBI_8214

http://purl.obolibrary.org/obo/CHEBI_102524

http://purl.obolibrary.org/obo/CHEBI_9948

http://purl.obolibrary.org/obo/CHEBI_157175

http://purl.obolibrary.org/obo/CHEBI_8107

http://purl.obolibrary.org/obo/CHEBI_10100

http://purl.obolibrary.org/obo/dinto_DB00822

http://purl.obolibrary.org/obo/CHEBI_3437

http://purl.obolibrary.org/obo/dinto_DB00794

http://purl.obolibrary.org/obo/CHEBI_9939

http://purl.obolibrary.org/obo/dinto_DB00306

http://purl.obolibrary.org/obo/CHEBI_16335

http://purl.obolibrary.org/obo/CHEBI_4888

http://purl.obolibrary.org/obo/CHEBI_8499

http://purl.obolibrary.org/obo/dinto_DB01355

http://purl.obolibrary.org/obo/dinto_DB00806

http://purl.obolibrary.org/obo/dinto_DB00011

http://purl.obolibrary.org/obo/dinto_DB00857

http://purl.obolibrary.org/obo/CHEBI_102216

http://purl.obolibrary.org/obo/CHEBI_5615

http://purl.obolibrary.org/obo/dinto_DB00231

http://purl.obolibrary.org/obo/CHEBI_63622

http://purl.obolibrary.org/obo/dinto_DB00532

http://purl.obolibrary.org/obo/CHEBI_8069

http://purl.obolibrary.org/obo/dinto_DB01336

http://purl.obolibrary.org/obo/CHEBI_2453

http://purl.obolibrary.org/obo/dinto_DB00312

http://purl.obolibrary.org/obo/dinto_DB01226

http://purl.obolibrary.org/obo/CHEBI_3699

http://purl.obolibrary.org/obo/dinto_DB00373

http://purl.obolibrary.org/obo/dinto_DB01354

http://purl.obolibrary.org/obo/dinto_DB01323

http://purl.obolibrary.org/obo/dinto_DB00034

http://purl.obolibrary.org/obo/dinto_DB01357

http://purl.obolibrary.org/obo/dinto_DB00237

http://purl.obolibrary.org/obo/dinto_DB00105

http://purl.obolibrary.org/obo/dinto_DB01558

http://purl.obolibrary.org/obo/dinto_DB01361

http://purl.obolibrary.org/obo/dinto_DB01352

http://purl.obolibrary.org/obo/dinto_DB00365

http://purl.obolibrary.org/obo/CHEBI_8887

http://purl.obolibrary.org/obo/CHEBI_6916

http://purl.obolibrary.org/obo/dinto_DB01356

http://purl.obolibrary.org/obo/CHEBI_100241

http://purl.obolibrary.org/obo/CHEBI_100246

http://purl.obolibrary.org/obo/dinto_DB01359

http://purl.obolibrary.org/obo/CHEBI_6758

http://purl.obolibrary.org/obo/CHEBI_5138

http://purl.obolibrary.org/obo/CHEBI_3387

http://purl.obolibrary.org/obo/CHEBI_10112

http://purl.obolibrary.org/obo/CHEBI_8466

http://purl.obolibrary.org/obo/CHEBI_7907

http://purl.obolibrary.org/obo/CHEBI_9774

http://purl.obolibrary.org/obo/CHEBI_3732

http://purl.obolibrary.org/obo/dinto_DB00022

http://purl.obolibrary.org/obo/CHEBI_2914

http://purl.obolibrary.org/obo/dinto_DB01351

http://purl.obolibrary.org/obo/dinto_DB00382

http://purl.obolibrary.org/obo/CHEBI_50199

http://purl.obolibrary.org/obo/CHEBI_9588

http://purl.obolibrary.org/obo/CHEBI_45979

http://purl.obolibrary.org/obo/dinto_DB06213

http://purl.obolibrary.org/obo/dinto_DB00199

http://purl.obolibrary.org/obo/CHEBI_7444

http://purl.obolibrary.org/obo/dinto_DB00977

http://purl.obolibrary.org/obo/dinto_DB00008

http://purl.obolibrary.org/obo/dinto_DB00503

http://purl.obolibrary.org/obo/CHEBI_31739

http://purl.obolibrary.org/obo/dinto_DB01320

http://purl.obolibrary.org/obo/CHEBI_28077

http://purl.obolibrary.org/obo/CHEBI_4707

http://purl.obolibrary.org/obo/dinto_DB01346

http://purl.obolibrary.org/obo/dinto_DB01353

http://purl.obolibrary.org/obo/dinto_DB01341

http://purl.obolibrary.org/obo/CHEBI_9073

http://purl.obolibrary.org/obo/dinto_DB00951

modulates

http://purl.obolibrary.org/obo/dinto_1538

http://purl.obolibrary.org/obo/dinto_0932

prefixIRI

obo2:dinto_DB01223

prefLabel

aminophylline

related with

http://purl.obolibrary.org/obo/dinto_3000

SMILES

NCCN.CN1C2=C(NC=N2)C(=O)N(C)C1=O.CN1C2=C(NC=N2)C(=O)N(C)C1=O

Synonym

C16H24N10O4

bis(1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione); ethane-1,2-diamine

xref

PubChem Compound:9433

ChemSpider:9062

Drugs Product Database (DPD):582662

Drugs.com:http://www.drugs.com/cdi/aminophylline.html

Wikipedia:http://en.wikipedia.org/wiki/Aminophylline

PubChem Substance:46508784

National Drug Code Directory:0517-3810-25

PharmGKB:PA164781029

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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Delete Mapping To Ontology Source
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.759.758.824.751.075 RH-MESH LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000682624 PDQ LOOM
http://stirdf.jst.go.jp/id/200907000631937616 IOBC LOOM
http://purl.obolibrary.org/obo/NCIT_C47393 BERO LOOM
https://go.drugbank.com/drugs/DB01223 MDM LOOM
http://purl.bioontology.org/ontology/MESH/D000628 MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_2659 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_2659 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_2659 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_2659 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_2659 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_2659 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_2659 CHEBI LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.782.258.368.050 RH-MESH LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassa6cdca56_ad43_408d_831d_3f52b112e94e WWECA LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016203 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/SNMI/C-69520 SNMI LOOM
http://purl.bioontology.org/ontology/ATC/R03DA05 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D000628 RH-MESH LOOM
http://purl.bioontology.org/ontology/RXNORM/689 RXNORM LOOM
http://www.drugbank.ca/drugs/DB01223 FTC LOOM
http://purl.obolibrary.org/obo/OMIT_0002044 OMIT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0002575 OCHV LOOM
http://childhealthservicemodels.eu/asthma#MOCHA-Asthma_000100 AO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#1018 OCHV LOOM
http://purl.bioontology.org/ontology/VANDF/4018056 VANDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373508009 SNOMEDCT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C47393 NCIT LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146397 NDFRT LOOM
http://purl.bioontology.org/ontology/CSP/2503-3703 CRISP LOOM
http://purl.bioontology.org/ontology/RCD/c41.. RCD LOOM
http://purl.obolibrary.org/obo/MESH_D000628 BERO LOOM
http://www.co-ode.org/ontologies/galen#Aminophylline GALEN LOOM
http://purl.jp/bio/4/id/200906097143533875 IOBC LOOM
http://purl.bioontology.org/ontology/NDDF/000608 NDDF LOOM