The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
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Preferred Name

halofantrine
Synonyms

3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol

C26H30Cl2F3NO
ID

http://purl.obolibrary.org/obo/dinto_DB01218
ATCCode

P01BX01
binds

http://purl.obolibrary.org/obo/dinto_3187

http://purl.obolibrary.org/obo/dinto_3550

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_2202

http://purl.obolibrary.org/obo/dinto_2990

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_1221
blocks

http://purl.obolibrary.org/obo/dinto_2202
CASRN

69756-53-2
DBBrand

halfan
DBSynonym

halofantrina [inn-spanish]

halofantrinum [inn-latin]

halofantrine [usan]
Definition

Halofantrine is a drug used to treat malaria. It belongs to the phenanthrene class of compounds that includes quinine and lumefantrine. It appears to inhibit polymerisation of heme molecules (by the parasite enzyme "heme polymerase"), resulting in the parasite being poisoned by its own waste. Halofantrine has been shown to preferentially block open and inactivated HERG channels leading to some degree of cardiotoxicity.
has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000599

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000660

http://purl.obolibrary.org/obo/OAE_0001051

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000608

http://purl.obolibrary.org/obo/OAE_0000632

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000551

http://purl.obolibrary.org/obo/OAE_0000243

http://purl.obolibrary.org/obo/OAE_0000864

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000607

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0001403

http://purl.obolibrary.org/obo/OAE_0000306

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0001345

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0001309

http://purl.obolibrary.org/obo/OAE_0000534

http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target

http://purl.obolibrary.org/obo/dinto_3187

http://purl.obolibrary.org/obo/dinto_2202
InChI

InChI=1S/C26H30Cl2F3NO/c1-3-5-10-32(11-6-4-2)12-9-25(33)23-16-22-21(14-18(27)15-24(22)28)20-13-17(26(29,30)31)7-8-19(20)23/h7-8,13-16,25,33H,3-6,9-12H2,1-2H3
InChIKey

InChIKey=FOHHNHSLJDZUGQ-UHFFFAOYSA-N
inhibits

http://purl.obolibrary.org/obo/dinto_3187

http://purl.obolibrary.org/obo/dinto_3550

http://purl.obolibrary.org/obo/dinto_2993
is metabolised by

http://purl.obolibrary.org/obo/dinto_2990

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_1221
is substrate of

http://purl.obolibrary.org/obo/dinto_2990

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_1221
label

halofantrine
may interact with

http://purl.obolibrary.org/obo/CHEBI_9948

http://purl.obolibrary.org/obo/CHEBI_156095

http://purl.obolibrary.org/obo/CHEBI_61049

http://purl.obolibrary.org/obo/dinto_DB00726

http://purl.obolibrary.org/obo/CHEBI_63609

http://purl.obolibrary.org/obo/CHEBI_6780

http://purl.obolibrary.org/obo/CHEBI_9566

http://purl.obolibrary.org/obo/CHEBI_51364

http://purl.obolibrary.org/obo/CHEBI_3764

http://purl.obolibrary.org/obo/CHEBI_681850

http://purl.obolibrary.org/obo/dinto_DB00582

http://purl.obolibrary.org/obo/CHEBI_10119

http://purl.obolibrary.org/obo/CHEBI_9635

http://purl.obolibrary.org/obo/CHEBI_64355

http://purl.obolibrary.org/obo/CHEBI_45716

http://purl.obolibrary.org/obo/CHEBI_3090

http://purl.obolibrary.org/obo/dinto_DB01369

http://purl.obolibrary.org/obo/CHEBI_195280

http://purl.obolibrary.org/obo/dinto_DB01623

http://purl.obolibrary.org/obo/dinto_DB00976
modulates

http://purl.obolibrary.org/obo/dinto_2202
prefixIRI

obo2:dinto_DB01218
prefLabel

halofantrine
SMILES

CCCCN(CCCC)CCC(O)C1=C2C=CC(=CC2=C2C=C(Cl)C=C(Cl)C2=C1)C(F)(F)F
Synonym

3-(dibutylamino)-1-[1,3-dichloro-6-(trifluoromethyl)phenanthren-9-yl]propan-1-ol

C26H30Cl2F3NO
xref

PubChem Substance:46506753

Wikipedia:http://en.wikipedia.org/wiki/Halofantrine

Drugs.com:http://www.drugs.com/cdi/halofantrine.html

BindingDB:50096846

Drugs Product Database (DPD):2162857

PubChem Compound:37393

ChemSpider:34303

PharmGKB:PA449839
subClassOf

http://purl.obolibrary.org/obo/dinto_000055
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