The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	lomustine
Synonyms	3-(2-chloroethyl)-1-cyclohexyl-3-nitrosourea C9H16ClN3O2
ID	http://purl.obolibrary.org/obo/dinto_DB01206
AHFScode	10:00.00
ATCCode	L01AD02
binds	http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_2873 http://purl.obolibrary.org/obo/dinto_4272
blocks	http://purl.obolibrary.org/obo/dinto_4272
CASRN	13010-47-4
DBBrand	ceenu cecenu cinu belustine
DBSynonym	lomustina [inn-spanish] chloroethylcyclohexylnitrosourea ccnu lomustinum [inn-latin]
Definition	An alkylating agent of value against both hematologic malignancies and solid tumors. [PubChem]
has effect	http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000577 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000981 http://purl.obolibrary.org/obo/OAE_0001341 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0001145 http://purl.obolibrary.org/obo/OAE_0000898 http://purl.obolibrary.org/obo/OAE_0000881 http://purl.obolibrary.org/obo/OAE_0001364
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2873
InChI	InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)
InChIKey	InChIKey=GQYIWUVLTXOXAJ-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901
is metabolised by	http://purl.obolibrary.org/obo/dinto_2993
is substrate of	http://purl.obolibrary.org/obo/dinto_2993
label	lomustine
may interact with	http://purl.obolibrary.org/obo/CHEBI_127342 http://purl.obolibrary.org/obo/dinto_DB00857 http://purl.obolibrary.org/obo/dinto_DB00072
modulates	http://purl.obolibrary.org/obo/dinto_4272
prefixIRI	obo2:dinto_DB01206
prefLabel	lomustine
related with	http://purl.obolibrary.org/obo/dinto_2873
SMILES	ClCCN(N=O)C(=O)NC1CCCCC1
Synonym	3-(2-chloroethyl)-1-cyclohexyl-3-nitrosourea C9H16ClN3O2
xref	Wikipedia:http://en.wikipedia.org/wiki/Lomustine Drugs.com:http://www.drugs.com/cdi/lomustine-ccnu.html PubChem Compound:3950 National Drug Code Directory:0015-3030-20 Drugs Product Database (DPD):360414 RxList:http://www.rxlist.com/cgi/generic2/lomustine.htm PharmGKB:PA164749407 ChemSpider:3813 PubChem Substance:46506562
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
https://go.drugbank.com/drugs/DB01206	MDM	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387227009	SNOMEDCT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.654.692.440	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146475	NDFRT	LOOM
http://purl.jp/bio/4/id/200906091089654710	IOBC	LOOM
http://purl.bioontology.org/ontology/MESH/D008130	MESH	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C617	NCIT	LOOM
http://purl.bioontology.org/ontology/RXNORM/6466	RXNORM	LOOM
http://purl.bioontology.org/ontology/VANDF/4018138	VANDF	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0023972	OCHV	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017242	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/CSP/1371-8111	CRISP	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#7530	OCHV	LOOM
http://www.co-ode.org/ontologies/galen#Lomustine	GALEN	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008130	RH-MESH	LOOM
http://purl.obolibrary.org/obo/OMIT_0009213	OMIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.948.594.440	RH-MESH	LOOM
http://purl.obolibrary.org/obo/CHEBI_6520	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_6520	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6520	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6520	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_6520	CHEBI	LOOM
http://purl.obolibrary.org/obo/NCIT_C617	BERO	LOOM
http://purl.bioontology.org/ontology/SNMI/C-78120	SNMI	LOOM
http://stirdf.jst.go.jp/id/200907076376183510	IOBC	LOOM
http://www.ifomis.org/acgt/1.0#Lomustine	ACGT-MO	LOOM
http://purl.bioontology.org/ontology/RCD/h18..	RCD	LOOM
http://purl.bioontology.org/ontology/ATC/L01AD02	ATC	LOOM
http://purl.obolibrary.org/obo/MESH_D008130	BERO	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000043065	PDQ	LOOM
http://purl.bioontology.org/ontology/NDDF/002639	NDDF	LOOM