The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
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Preferred Name

itraconazole
Synonyms

C35H38Cl2N8O4

1-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
ID

http://purl.obolibrary.org/obo/dinto_DB01167
AHFScode

08:14.08
ATCCode

J02AC02
binds

http://purl.obolibrary.org/obo/dinto_4171

http://purl.obolibrary.org/obo/dinto_2990

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0293

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_1440

http://purl.obolibrary.org/obo/dinto_1956

http://purl.obolibrary.org/obo/dinto_3507

http://purl.obolibrary.org/obo/dinto_0465

http://purl.obolibrary.org/obo/dinto_0269
CASRN

84625-61-6
DBBrand

sporanox

sporonox

triasporn

itrizole

sporanos

sporal

oriconazole

hyphanox
DBSynonym

itz

itraconazolum [latin]

itraconazol [spanish]

itcz

itc
Definition

One of the triazole antifungal agents that inhibits cytochrome P-450-dependent enzymes resulting in impairment of ergosterol synthesis. It has been used against histoplasmosis, blastomycosis, cryptococcal meningitis and aspergillosis. [PubChem]
has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000496

http://purl.obolibrary.org/obo/OAE_0000424

http://purl.obolibrary.org/obo/OAE_0001059

http://purl.obolibrary.org/obo/OAE_0000449

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0001373

http://purl.obolibrary.org/obo/OAE_0000597

http://purl.obolibrary.org/obo/OAE_0000604

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0000839

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0000443

http://purl.obolibrary.org/obo/OAE_0000921

http://purl.obolibrary.org/obo/OAE_0000308

http://purl.obolibrary.org/obo/OAE_0001369

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0000415

http://purl.obolibrary.org/obo/OAE_0000195

http://purl.obolibrary.org/obo/OAE_0000545

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0000418

http://purl.obolibrary.org/obo/OAE_0000210

http://purl.obolibrary.org/obo/OAE_0000021

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0000317

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0001025

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000050

http://purl.obolibrary.org/obo/OAE_0000476

http://purl.obolibrary.org/obo/OAE_0000608

http://purl.obolibrary.org/obo/OAE_0000403

http://purl.obolibrary.org/obo/OAE_0001254

http://purl.obolibrary.org/obo/OAE_0001055

http://purl.obolibrary.org/obo/OAE_0001026

http://purl.obolibrary.org/obo/OAE_0000632

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0001463

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000300

http://purl.obolibrary.org/obo/OAE_0000551

http://purl.obolibrary.org/obo/OAE_0001062

http://purl.obolibrary.org/obo/OAE_0000455

http://purl.obolibrary.org/obo/OAE_0000498

http://purl.obolibrary.org/obo/OAE_0000084

http://purl.obolibrary.org/obo/OAE_0001420

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0001135

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0001126

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000607

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0001164

http://purl.obolibrary.org/obo/OAE_0000968

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0001145

http://purl.obolibrary.org/obo/OAE_0000866

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000780

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0000536

http://purl.obolibrary.org/obo/OAE_0000647

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000779

http://purl.obolibrary.org/obo/OAE_0001052

http://purl.obolibrary.org/obo/OAE_0001217

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000565

http://purl.obolibrary.org/obo/OAE_0001345

http://purl.obolibrary.org/obo/OAE_0001001

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000211

http://purl.obolibrary.org/obo/OAE_0000358

http://purl.obolibrary.org/obo/OAE_0001309

http://purl.obolibrary.org/obo/OAE_0000766

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target

http://purl.obolibrary.org/obo/dinto_4171

http://purl.obolibrary.org/obo/dinto_3507
InChI

InChI=1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/m0/s1
InChIKey

InChIKey=VHVPQPYKVGDNFY-ZPGVKDDISA-N
induces

http://purl.obolibrary.org/obo/dinto_0269
inhibits

http://purl.obolibrary.org/obo/dinto_4171

http://purl.obolibrary.org/obo/dinto_2990

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0293

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_1440

http://purl.obolibrary.org/obo/dinto_1956

http://purl.obolibrary.org/obo/dinto_3507

http://purl.obolibrary.org/obo/dinto_0465
is metabolised by

http://purl.obolibrary.org/obo/dinto_0901
is substrate of

http://purl.obolibrary.org/obo/dinto_0901
label

itraconazole
may interact with

http://purl.obolibrary.org/obo/dinto_DB00906

http://purl.obolibrary.org/obo/CHEBI_4975

http://purl.obolibrary.org/obo/dinto_DB00683

http://purl.obolibrary.org/obo/CHEBI_8212

http://purl.obolibrary.org/obo/CHEBI_71219

http://purl.obolibrary.org/obo/CHEBI_32250

http://purl.obolibrary.org/obo/CHEBI_66919

http://purl.obolibrary.org/obo/CHEBI_68478

http://purl.obolibrary.org/obo/CHEBI_391960

http://purl.obolibrary.org/obo/CHEBI_9948

http://purl.obolibrary.org/obo/CHEBI_9943

http://purl.obolibrary.org/obo/dinto_DB00801

http://purl.obolibrary.org/obo/CHEBI_4551

http://purl.obolibrary.org/obo/CHEBI_585948

http://purl.obolibrary.org/obo/CHEBI_8107

http://purl.obolibrary.org/obo/CHEBI_4317

http://purl.obolibrary.org/obo/dinto_DB00585

http://purl.obolibrary.org/obo/CHEBI_49668

http://purl.obolibrary.org/obo/CHEBI_71940

http://purl.obolibrary.org/obo/CHEBI_68642

http://purl.obolibrary.org/obo/CHEBI_41774

http://purl.obolibrary.org/obo/CHEBI_66901

http://purl.obolibrary.org/obo/dinto_DB00541

http://purl.obolibrary.org/obo/CHEBI_28901

http://purl.obolibrary.org/obo/dinto_DB00243

http://purl.obolibrary.org/obo/CHEBI_4888

http://purl.obolibrary.org/obo/CHEBI_499361

http://purl.obolibrary.org/obo/CHEBI_520985

http://purl.obolibrary.org/obo/CHEBI_10127

http://purl.obolibrary.org/obo/dinto_DB01591

http://purl.obolibrary.org/obo/CHEBI_31401

http://purl.obolibrary.org/obo/CHEBI_31547

http://purl.obolibrary.org/obo/CHEBI_4858

http://purl.obolibrary.org/obo/dinto_DB06207

http://purl.obolibrary.org/obo/CHEBI_4031

http://purl.obolibrary.org/obo/CHEBI_3207

http://purl.obolibrary.org/obo/CHEBI_8871

http://purl.obolibrary.org/obo/CHEBI_61049

http://purl.obolibrary.org/obo/dinto_DB00726

http://purl.obolibrary.org/obo/CHEBI_9150

http://purl.obolibrary.org/obo/CHEBI_5613

http://purl.obolibrary.org/obo/dinto_DB04855

http://purl.obolibrary.org/obo/CHEBI_3756

http://purl.obolibrary.org/obo/CHEBI_48390

http://purl.obolibrary.org/obo/dinto_DB00532

http://purl.obolibrary.org/obo/CHEBI_8069

http://purl.obolibrary.org/obo/dinto_DB06287

http://purl.obolibrary.org/obo/dinto_DB00342

http://purl.obolibrary.org/obo/CHEBI_53766

http://purl.obolibrary.org/obo/CHEBI_63632

http://purl.obolibrary.org/obo/CHEBI_3699

http://purl.obolibrary.org/obo/CHEBI_8776

http://purl.obolibrary.org/obo/CHEBI_3611

http://purl.obolibrary.org/obo/CHEBI_40303

http://purl.obolibrary.org/obo/dinto_DB01410

http://purl.obolibrary.org/obo/dinto_DB01370

http://purl.obolibrary.org/obo/CHEBI_8382

http://purl.obolibrary.org/obo/CHEBI_133809

http://purl.obolibrary.org/obo/CHEBI_31794

http://purl.obolibrary.org/obo/dinto_DB00364

http://purl.obolibrary.org/obo/CHEBI_3558

http://purl.obolibrary.org/obo/dinto_DB00570

http://purl.obolibrary.org/obo/dinto_DB01357

http://purl.obolibrary.org/obo/CHEBI_3761

http://purl.obolibrary.org/obo/CHEBI_681850

http://purl.obolibrary.org/obo/CHEBI_10125

http://purl.obolibrary.org/obo/CHEBI_72296

http://purl.obolibrary.org/obo/CHEBI_9654

http://purl.obolibrary.org/obo/dinto_DB06212

http://purl.obolibrary.org/obo/dinto_DB01558

http://purl.obolibrary.org/obo/CHEBI_8768

http://purl.obolibrary.org/obo/CHEBI_2611

http://purl.obolibrary.org/obo/CHEBI_6375

http://purl.obolibrary.org/obo/CHEBI_75988

http://purl.obolibrary.org/obo/CHEBI_68579

http://purl.obolibrary.org/obo/CHEBI_63637

http://purl.obolibrary.org/obo/dinto_DB08901

http://purl.obolibrary.org/obo/CHEBI_3387

http://purl.obolibrary.org/obo/CHEBI_51141

http://purl.obolibrary.org/obo/CHEBI_3720

http://purl.obolibrary.org/obo/CHEBI_39548

http://purl.obolibrary.org/obo/CHEBI_3732

http://purl.obolibrary.org/obo/CHEBI_480999

http://purl.obolibrary.org/obo/CHEBI_9622

http://purl.obolibrary.org/obo/CHEBI_45367

http://purl.obolibrary.org/obo/CHEBI_6888

http://purl.obolibrary.org/obo/CHEBI_9398

http://purl.obolibrary.org/obo/CHEBI_10033

http://purl.obolibrary.org/obo/CHEBI_32315

http://purl.obolibrary.org/obo/CHEBI_63628

http://purl.obolibrary.org/obo/CHEBI_31236

http://purl.obolibrary.org/obo/CHEBI_28593

http://purl.obolibrary.org/obo/CHEBI_9168

http://purl.obolibrary.org/obo/dinto_DB00199

http://purl.obolibrary.org/obo/CHEBI_9139

http://purl.obolibrary.org/obo/CHEBI_7915

http://purl.obolibrary.org/obo/CHEBI_4513

http://purl.obolibrary.org/obo/CHEBI_7772

http://purl.obolibrary.org/obo/CHEBI_6441

http://purl.obolibrary.org/obo/CHEBI_51450

http://purl.obolibrary.org/obo/dinto_DB00503

http://purl.obolibrary.org/obo/CHEBI_49575

http://purl.obolibrary.org/obo/CHEBI_31739

http://purl.obolibrary.org/obo/CHEBI_8378

http://purl.obolibrary.org/obo/dinto_DB00690

http://purl.obolibrary.org/obo/CHEBI_50275

http://purl.obolibrary.org/obo/CHEBI_63584

http://purl.obolibrary.org/obo/dinto_DB01373

http://purl.obolibrary.org/obo/dinto_DB01320

http://purl.obolibrary.org/obo/CHEBI_3311

http://purl.obolibrary.org/obo/CHEBI_2896

http://purl.obolibrary.org/obo/CHEBI_119915

http://purl.obolibrary.org/obo/CHEBI_50922

http://purl.obolibrary.org/obo/CHEBI_114785

http://purl.obolibrary.org/obo/CHEBI_28077

http://purl.obolibrary.org/obo/dinto_DB01589

http://purl.obolibrary.org/obo/CHEBI_68647

http://purl.obolibrary.org/obo/dinto_DB01346

http://purl.obolibrary.org/obo/CHEBI_9674

http://purl.obolibrary.org/obo/CHEBI_38940

http://purl.obolibrary.org/obo/CHEBI_64318

http://purl.obolibrary.org/obo/CHEBI_4681

http://purl.obolibrary.org/obo/CHEBI_70735

http://purl.obolibrary.org/obo/CHEBI_46295

http://purl.obolibrary.org/obo/dinto_DB00976

http://purl.obolibrary.org/obo/CHEBI_45783

http://purl.obolibrary.org/obo/CHEBI_2569

http://purl.obolibrary.org/obo/CHEBI_4562
prefixIRI

obo2:dinto_DB01167
prefLabel

itraconazole
SMILES

CCC(C)N1N=CN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(OC[C@H]2CO[C@@](CN3C=NC=N3)(O2)C2=C(Cl)C=C(Cl)C=C2)C=C1
Synonym

C35H38Cl2N8O4

1-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
xref

Drugs Product Database (DPD):2231347

Drugs.com:http://www.drugs.com/cdi/itraconazole.html

PubChem Substance:46505954

PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/spo1411.shtml

PubChem Compound:55283

National Drug Code Directory:50458-295-15

Wikipedia:http://en.wikipedia.org/wiki/Itraconazole

ChemSpider:49927

RxList:http://www.rxlist.com/cgi/generic/itraconazole.htm

PharmGKB:PA450132

ChEBI:6076
subClassOf

http://purl.obolibrary.org/obo/dinto_000055
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Delete Mapping To Ontology Source
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Itraconazole SEPON LOOM
http://purl.obolibrary.org/obo/OMIT_0018220 OMIT LOOM
https://go.drugbank.com/drugs/DB01167 MDM LOOM
http://purl.bioontology.org/ontology/LNC/MTHU002298 LOINC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.129.799.550 RH-MESH LOOM
http://purl.obolibrary.org/obo/CHEBI_6076 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_6076 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_6076 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_6076 EUPATH LOOM
http://purl.obolibrary.org/obo/CHEBI_6076 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_6076 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_6076 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_6076 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_6076 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_6076 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_6076 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_6076 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_6076 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_6076 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_6076 FYPO LOOM
http://purl.obolibrary.org/obo/CHEBI_6076 DIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_6076 ODNAE LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018244 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/MESH/D017964 MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387532006 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/RXNORM/28031 RXNORM LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D017964 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0064113 OCHV LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1138 NCIT LOOM
http://purl.bioontology.org/ontology/VANDF/4020560 VANDF LOOM
http://purl.bioontology.org/ontology/CSP/4006-0055 CRISP LOOM
http://bmi.utah.edu/ontologies/hfontology/C0064113 HFO LOOM
http://purl.obolibrary.org/obo/MESH_D017964 BERO LOOM
http://purl.bioontology.org/ontology/SNMI/C-52BC0 SNMI LOOM
http://purl.bioontology.org/ontology/RCD/eh9.. RCD LOOM
http://purl.obolibrary.org/obo/NCIT_C1138 BERO LOOM
http://www.co-ode.org/ontologies/galen#Itraconazole GALEN LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.606.530 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB01167 FTC LOOM
http://purl.bioontology.org/ontology/LNC/LP14995-2 LOINC LOOM
http://purl.obolibrary.org/obo/ARO_3007511 ARO LOOM
http://purl.bioontology.org/ontology/ATC/J02AC02 ATC LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148264 ODAE LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14243 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148264 NDFRT LOOM
http://purl.bioontology.org/ontology/NDDF/003915 NDDF LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039106 PDQ LOOM