The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	guanfacine
Synonyms	N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide C9H9Cl2N3O
ID	http://purl.obolibrary.org/obo/dinto_DB01018
activates	http://purl.obolibrary.org/obo/dinto_1135
ATCCode	C02AC02
binds	http://purl.obolibrary.org/obo/dinto_1135 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901
CASRN	29110-47-2
DBBrand	tenex intuniv estulic
DBSynonym	guanfacine hcl spd 503 guanfacina [inn-spanish] guanfacinum [inn-latin] guanfacine hydrochloride
Definition	A centrally acting antihypertensive agent. The drug lowers both systolic and diastolic blood pressure by activating the central nervous system alpha-2 adrenoreceptors, which results in reduced sympathetic outflow leading to reduced vascular tone. Its adverse reactions include dry mouth, sedation, and constipation. [PubChem]
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0001297 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0000604 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0000443 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000205 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000482 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0000476 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000687 http://purl.obolibrary.org/obo/OAE_0001105 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000606 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000421 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000296 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0000534 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target	http://purl.obolibrary.org/obo/dinto_1135
InChI	InChI=1S/C9H9Cl2N3O/c10-6-2-1-3-7(11)5(6)4-8(15)14-9(12)13/h1-3H,4H2,(H4,12,13,14,15)
InChIKey	InChIKey=INJOMKTZOLKMBF-UHFFFAOYSA-N
is metabolised by	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901
is substrate of	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901
label	guanfacine
may interact with	http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/CHEBI_50861
modulates	http://purl.obolibrary.org/obo/dinto_1135
prefixIRI	obo2:dinto_DB01018
prefLabel	guanfacine
SMILES	NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl
Synonym	N-carbamimidoyl-2-(2,6-dichlorophenyl)acetamide C9H9Cl2N3O
xref	RxList:http://www.rxlist.com/cgi/generic3/guanfacine.htm IUPHAR:522 PubChem Compound:3519 Drugs.com:http://www.drugs.com/cdi/guanfacine.html Wikipedia:http://en.wikipedia.org/wiki/Guanfacine ChemSpider:3399 National Drug Code Directory:55567-051-18 PubChem Substance:46506169 PharmGKB:PA449825 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/gua1657.shtml Guide To Pharmacology:522
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61779	NCIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.241.223.601.329	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.078.370.465	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NDDF/004497	NDDF	LOOM
http://purl.bioontology.org/ontology/LNC/LP432409-3	LOINC	LOOM
http://purl.bioontology.org/ontology/MESH/D016316	MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#15178	OCHV	LOOM
http://www.drugbank.ca/drugs/DB01018	FTC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D016316	RH-MESH	LOOM
http://purl.bioontology.org/ontology/ATC/C02AC02	ATC	LOOM
http://purl.jp/bio/4/id/200906079641796885	IOBC	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016015	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU068486	LOINC	LOOM
http://purl.bioontology.org/ontology/VANDF/4019771	VANDF	LOOM
http://purl.obolibrary.org/obo/NCIT_C61779	BERO	LOOM
http://stirdf.jst.go.jp/id/200907062812203300	IOBC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0079466	OCHV	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147862	NDFRT	LOOM
http://purl.obolibrary.org/obo/MESH_D016316	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5558	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5558	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5558	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_5558	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5558	DRON	LOOM
http://purl.obolibrary.org/obo/OMIT_0016845	OMIT	LOOM
https://go.drugbank.com/drugs/DB01018	MDM	LOOM
http://purl.bioontology.org/ontology/RXNORM/40114	RXNORM	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372507007	SNOMEDCT	LOOM