The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	pentoxifylline
Synonyms	C13H18N4O3 3,7-dimethyl-1-(5-oxohexyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
ID	http://purl.obolibrary.org/obo/dinto_DB00806
AHFScode	20:24.00
ATCCode	C04AD03
binds	http://purl.obolibrary.org/obo/dinto_1637 http://purl.obolibrary.org/obo/dinto_4063 http://purl.obolibrary.org/obo/dinto_0074 http://purl.obolibrary.org/obo/dinto_0152 http://purl.obolibrary.org/obo/dinto_3607 http://purl.obolibrary.org/obo/dinto_0932 http://purl.obolibrary.org/obo/dinto_2651
blocks	http://purl.obolibrary.org/obo/dinto_3607 http://purl.obolibrary.org/obo/dinto_0932
CASRN	6493-05-6
DBBrand	pentoxil pentoxiphyllium trental durapental vazofirin dimethyloxohexylxanthine pentoxyphylline torental pentoxyphyline pentoxyfylline rentylin oxpentifylline pentoxifyllin azupentat
DBSynonym	eht0201
Definition	A methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production. [PubChem]
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000335 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0001025 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000476 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0001168 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0000287 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0000517 http://purl.obolibrary.org/obo/OAE_0000502 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000473 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000438 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000242 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000811
has pharmacological target	http://purl.obolibrary.org/obo/dinto_3607 http://purl.obolibrary.org/obo/dinto_1637 http://purl.obolibrary.org/obo/dinto_4063 http://purl.obolibrary.org/obo/dinto_0074 http://purl.obolibrary.org/obo/dinto_0932
InChI	InChI=1S/C13H18N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8H,4-7H2,1-3H3
InChIKey	InChIKey=BYPFEZZEUUWMEJ-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_1637 http://purl.obolibrary.org/obo/dinto_4063 http://purl.obolibrary.org/obo/dinto_0074 http://purl.obolibrary.org/obo/dinto_0152
is metabolised by	http://purl.obolibrary.org/obo/dinto_2651
is substrate of	http://purl.obolibrary.org/obo/dinto_2651
label	pentoxifylline
may interact with	http://purl.obolibrary.org/obo/dinto_DB01303 http://purl.obolibrary.org/obo/dinto_DB01223 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/CHEBI_4728 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/dinto_DB00046 http://purl.obolibrary.org/obo/CHEBI_28177
modulates	http://purl.obolibrary.org/obo/dinto_3607 http://purl.obolibrary.org/obo/dinto_0932
prefixIRI	obo2:dinto_DB00806
prefLabel	pentoxifylline
SMILES	CN1C=NC2=C1C(=O)N(CCCCC(C)=O)C(=O)N2C
Synonym	C13H18N4O3 3,7-dimethyl-1-(5-oxohexyl)-2,3,6,7-tetrahydro-1H-purine-2,6-dione
xref	National Drug Code Directory:0378-0357-01 RxList:http://www.rxlist.com/cgi/generic/pentox.htm BindingDB:10850 ChemSpider:4578 Drugs.com:http://www.drugs.com/cdi/pentoxifylline.html PubChem Substance:46505940 Drugs Product Database (DPD):1968432 Wikipedia:http://en.wikipedia.org/wiki/Pentoxifylline PharmGKB:PA450864 PubChem Compound:4740
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.bioontology.org/ontology/CSP/4006-0076	CRISP	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387522004	SNOMEDCT	LOOM
http://purl.obolibrary.org/obo/CHEBI_7986	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_7986	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_7986	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_7986	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_7986	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_7986	DRON	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU035938	LOINC	LOOM
http://purl.obolibrary.org/obo/XCO_0001204	XCO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#9447	OCHV	LOOM
http://purl.obolibrary.org/obo/OMIT_0011425	OMIT	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041432	PDQ	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017863	PMAPP-PMO	LOOM
https://go.drugbank.com/drugs/DB00806	MDM	LOOM
http://purl.bioontology.org/ontology/SNMI/C-A7210	SNMI	LOOM
http://purl.bioontology.org/ontology/LNC/LP14918-4	LOINC	LOOM
http://purl.bioontology.org/ontology/ATC/C04AD03	ATC	LOOM
http://purl.obolibrary.org/obo/MESH_D010431	BERO	LOOM
http://purl.bioontology.org/ontology/MESH/D010431	MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D010431	RH-MESH	LOOM
http://purl.bioontology.org/ontology/RXNORM/8013	RXNORM	LOOM
http://stirdf.jst.go.jp/id/200907035146649783	IOBC	LOOM
http://purl.bioontology.org/ontology/VANDF/4018468	VANDF	LOOM
http://purl.bioontology.org/ontology/NDDF/002098	NDDF	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C733	NCIT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0030899	OCHV	LOOM
http://purl.obolibrary.org/obo/NCIT_C733	BERO	LOOM
http://www.drugbank.ca/drugs/DB00806	FTC	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146791	NDFRT	LOOM
http://purl.jp/bio/4/id/200906055042872488	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.759.758.824.651.700	RH-MESH	LOOM