The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	dolasetron
Synonyms	C19H20N2O3 (3R)-10-oxo-8-azatricyclo[5.3.1.0^{3,8}]undecan-5-yl 1H-indole-3-carboxylate
ID	http://purl.obolibrary.org/obo/dinto_DB00757
AHFScode	56:22.20
ATCCode	A04AA04
blocks	http://purl.obolibrary.org/obo/dinto_1123
CASRN	115956-12-2
DBBrand	dolasetronum [inn-latin] dolasteron anzemet
Definition	Dolasetron is an antinauseant and antiemetic agent indicated for the prevention of nausea and vomiting associated with moderately-emetogenic cancer chemotherapy and for the prevention of postoperative nausea and vomiting. Dolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. This drug has not shown to have activity at other known serotonin receptors, and has low affinity for dopamine receptors.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000879 http://purl.obolibrary.org/obo/OAE_0001297 http://purl.obolibrary.org/obo/OAE_0001285 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000198 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000650 http://purl.obolibrary.org/obo/OAE_0000301 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0001489 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0001707 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000545 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0001436 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0001339 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0001538 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0000287 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001200 http://purl.obolibrary.org/obo/OAE_0000286 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000510 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001135 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000243 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0001403 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000194 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000618 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target	http://purl.obolibrary.org/obo/dinto_1123
InChI	InChI=1S/C19H20N2O3/c22-18-10-21-12-5-11(18)6-13(21)8-14(7-12)24-19(23)16-9-20-17-4-2-1-3-15(16)17/h1-4,9,11-14,20H,5-8,10H2/t11?,12-,13?,14?/m1/s1
InChIKey	InChIKey=UKTAZPQNNNJVKR-DBBXXEFVSA-N
is metabolised by	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901
label	dolasetron
may interact with	http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/CHEBI_51364 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/CHEBI_10119 http://purl.obolibrary.org/obo/CHEBI_9635 http://purl.obolibrary.org/obo/CHEBI_45716 http://purl.obolibrary.org/obo/CHEBI_195280 http://purl.obolibrary.org/obo/dinto_DB01623
prefixIRI	obo2:dinto_DB00757
prefLabel	dolasetron
SMILES	[H][C@]12CC(CC3CC(C1)C(=O)CN23)OC(=O)C1=CNC2=CC=CC=C12
Synonym	C19H20N2O3 (3R)-10-oxo-8-azatricyclo[5.3.1.0^{3,8}]undecan-5-yl 1H-indole-3-carboxylate
xref	RxList:http://www.rxlist.com/cgi/generic2/dolaset.htm Wikipedia:http://en.wikipedia.org/wiki/Dolasetron Drugs Product Database (DPD):2231380 ChemSpider:54666 PharmGKB:PA449390 National Drug Code Directory:0088-1208-06 Drugs.com:http://www.drugs.com/cdi/dolasetron.html PubChem Compound:60654 PubChem Substance:46505209
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_4682	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_4682	CHEBI	LOOM
http://purl.obolibrary.org/obo/NCIT_C61735	BERO	LOOM
http://purl.bioontology.org/ontology/MESH/C060344	MESH	LOOM
https://go.drugbank.com/drugs/DB00757	MDM	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025248	PMAPP-PMO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C060344	RH-MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0209210	OCHV	LOOM
http://purl.bioontology.org/ontology/ATC/A04AA04	ATC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#21091	OCHV	LOOM
http://purl.bioontology.org/ontology/NDDF/006880	NDDF	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372488002	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/RXNORM/68091	RXNORM	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022087	NDFRT	LOOM
http://www.drugbank.ca/drugs/DB00757	FTC	LOOM
http://purl.bioontology.org/ontology/VANDF/4024082	VANDF	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61735	NCIT	LOOM
http://purl.obolibrary.org/obo/CHEBI_4682	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4682	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4682	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_4682	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_4682	NIFSTD	LOOM