The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

tobramycin
Synonyms

(2S,3R,4S,5S,6R)-4-amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol

C18H37N5O9

ID

http://purl.obolibrary.org/obo/dinto_DB00684

AHFScode

52:04.04

08:12.02

ATCCode

S01AA12

J01GB01

binds

http://purl.obolibrary.org/obo/dinto_1191

http://purl.obolibrary.org/obo/dinto_2863

http://purl.obolibrary.org/obo/dinto_4093

CASRN

32986-56-4

DBBrand

nebramycin 6

aktob

nebramycin

nebcin

tobramaxin

tenebrimycin

nf 6

tobrex

gernebcin

distobram

tobradistin

tenemycin

nebramycin vi

sybryx

obramycin

tobrasone

tobramitsetin

tobramycetin

obracin

tobi

nebramycin factor 6

nebramycin factir 6

tobracin

tobradex

DBSynonym

tobramycin sulfate

3'-deoxykanamycin b

tobramycin solution for inhalation

sprc-ab01

Definition

An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is a 10% component of the antibiotic complex, nebramycin, produced by the same species. [PubChem]

has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000453

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000376

http://purl.obolibrary.org/obo/OAE_0000617

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0000411

http://purl.obolibrary.org/obo/OAE_0000308

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0000545

http://purl.obolibrary.org/obo/OAE_0000373

http://purl.obolibrary.org/obo/OAE_0001013

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000920

http://purl.obolibrary.org/obo/OAE_0000103

http://purl.obolibrary.org/obo/OAE_0000340

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000502

http://purl.obolibrary.org/obo/OAE_0001420

http://purl.obolibrary.org/obo/OAE_0000434

http://purl.obolibrary.org/obo/OAE_0001295

http://purl.obolibrary.org/obo/OAE_0001190

http://purl.obolibrary.org/obo/OAE_0000268

http://purl.obolibrary.org/obo/OAE_0000206

http://purl.obolibrary.org/obo/OAE_0000086

http://purl.obolibrary.org/obo/OAE_0000586

http://purl.obolibrary.org/obo/OAE_0000645

http://purl.obolibrary.org/obo/OAE_0000584

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0000473

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000607

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000866

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000343

http://purl.obolibrary.org/obo/OAE_0001147

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000390

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000881

http://purl.obolibrary.org/obo/OAE_0000394

http://purl.obolibrary.org/obo/OAE_0000211

http://purl.obolibrary.org/obo/OAE_0000358

http://purl.obolibrary.org/obo/OAE_0001366

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0000350

has pharmacological target

http://purl.obolibrary.org/obo/dinto_1191

InChI

InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1

InChIKey

InChIKey=NLVFBUXFDBBNBW-PBSUHMDJSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_1191

http://purl.obolibrary.org/obo/dinto_2863

is metabolised by

http://purl.obolibrary.org/obo/dinto_4093

is substrate of

http://purl.obolibrary.org/obo/dinto_4093

label

tobramycin

may interact with

http://purl.obolibrary.org/obo/CHEBI_553473

http://purl.obolibrary.org/obo/CHEBI_3213

http://purl.obolibrary.org/obo/CHEBI_490877

http://purl.obolibrary.org/obo/CHEBI_8107

http://purl.obolibrary.org/obo/CHEBI_9434

http://purl.obolibrary.org/obo/CHEBI_8024

http://purl.obolibrary.org/obo/CHEBI_9939

http://purl.obolibrary.org/obo/CHEBI_5959

http://purl.obolibrary.org/obo/CHEBI_3499

http://purl.obolibrary.org/obo/CHEBI_3491

http://purl.obolibrary.org/obo/CHEBI_3493

http://purl.obolibrary.org/obo/CHEBI_3495

http://purl.obolibrary.org/obo/CHEBI_9927

http://purl.obolibrary.org/obo/dinto_DB01338

http://purl.obolibrary.org/obo/CHEBI_3480

http://purl.obolibrary.org/obo/CHEBI_474053

http://purl.obolibrary.org/obo/CHEBI_6541

http://purl.obolibrary.org/obo/CHEBI_28001

http://purl.obolibrary.org/obo/CHEBI_4031

http://purl.obolibrary.org/obo/dinto_DB03450

http://purl.obolibrary.org/obo/CHEBI_61049

http://purl.obolibrary.org/obo/CHEBI_8713

http://purl.obolibrary.org/obo/CHEBI_9513

http://purl.obolibrary.org/obo/dinto_DB01336

http://purl.obolibrary.org/obo/dinto_DB01226

http://purl.obolibrary.org/obo/dinto_DB00214

http://purl.obolibrary.org/obo/CHEBI_45652

http://purl.obolibrary.org/obo/CHEBI_8774

http://purl.obolibrary.org/obo/CHEBI_9332

http://purl.obolibrary.org/obo/CHEBI_204928

http://purl.obolibrary.org/obo/CHEBI_3508

http://purl.obolibrary.org/obo/CHEBI_2682

http://purl.obolibrary.org/obo/CHEBI_63577

http://purl.obolibrary.org/obo/CHEBI_29007

http://purl.obolibrary.org/obo/dinto_DB01112

http://purl.obolibrary.org/obo/CHEBI_27690

http://purl.obolibrary.org/obo/CHEBI_9241

http://purl.obolibrary.org/obo/CHEBI_554446

http://purl.obolibrary.org/obo/CHEBI_63631

http://purl.obolibrary.org/obo/CHEBI_8884

http://purl.obolibrary.org/obo/dinto_DB01356

http://purl.obolibrary.org/obo/CHEBI_3347

http://purl.obolibrary.org/obo/CHEBI_48416

http://purl.obolibrary.org/obo/CHEBI_3380

http://purl.obolibrary.org/obo/CHEBI_7907

http://purl.obolibrary.org/obo/CHEBI_5163

http://purl.obolibrary.org/obo/CHEBI_9774

http://purl.obolibrary.org/obo/CHEBI_209807

http://purl.obolibrary.org/obo/CHEBI_3011

http://purl.obolibrary.org/obo/CHEBI_43755

http://purl.obolibrary.org/obo/CHEBI_2914

http://purl.obolibrary.org/obo/dinto_DB00440

http://purl.obolibrary.org/obo/CHEBI_28304

http://purl.obolibrary.org/obo/CHEBI_9587

http://purl.obolibrary.org/obo/CHEBI_4876

http://purl.obolibrary.org/obo/CHEBI_59662

http://purl.obolibrary.org/obo/CHEBI_47426

http://purl.obolibrary.org/obo/CHEBI_27899

http://purl.obolibrary.org/obo/CHEBI_3547

http://purl.obolibrary.org/obo/CHEBI_4784

http://purl.obolibrary.org/obo/CHEBI_4707

prefixIRI

obo2:dinto_DB00684

prefLabel

tobramycin

SMILES

NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](N)C[C@@H]1O

Synonym

(2S,3R,4S,5S,6R)-4-amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol

C18H37N5O9

xref

RxList:http://www.rxlist.com/cgi/generic/tobi.htm

ChemSpider:33377

ChEBI:28864

Wikipedia:http://en.wikipedia.org/wiki/Tobramycin

PharmGKB:PA451704

PDB:TOY

BindingDB:50090265

Drugs.com:http://www.drugs.com/cdi/tobramycin-drops.html

National Drug Code Directory:0065-0643-05

Drugs Product Database (DPD):2241209

PubChem Substance:46507662

PubChem Compound:36294

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_28864 OBI LOOM
http://purl.obolibrary.org/obo/CHEBI_28864 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_28864 CHEBI LOOM
http://purl.obolibrary.org/obo/ARO_0000052 ARO LOOM
http://purl.bioontology.org/ontology/RXNORM/10627 RXNORM LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146911 ODAE LOOM
http://purl.jp/bio/4/id/200906092877719276 IOBC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#12328 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146911 NDFRT LOOM
http://purl.bioontology.org/ontology/LNC/LP16294-8 LOINC LOOM
http://purl.obolibrary.org/obo/CHEBI_28864 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_28864 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_28864 EUPATH LOOM
http://purl.obolibrary.org/obo/CHEBI_28864 CCONT LOOM
http://purl.obolibrary.org/obo/CHEBI_28864 GO-PLUS LOOM
http://purl.obolibrary.org/obo/CHEBI_28864 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_28864 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_28864 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_28864 UPHENO LOOM
http://purl.obolibrary.org/obo/CHEBI_28864 NIFSTD LOOM
http://purl.obolibrary.org/obo/CHEBI_28864 PHIPO LOOM
http://purl.obolibrary.org/obo/CHEBI_28864 GENEPIO LOOM
http://purl.obolibrary.org/obo/CHEBI_28864 ODNAE LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004270 LOINC LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00744 COID LOOM
http://www.co-ode.org/ontologies/galen#Tobramycin GALEN LOOM
http://purl.bioontology.org/ontology/MESH/D014031 MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D014031 RH-MESH LOOM
http://stirdf.jst.go.jp/id/200907025239684664 IOBC LOOM
http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Tobramycin SEPON LOOM
http://purl.bioontology.org/ontology/VANDF/4018595 VANDF LOOM
https://go.drugbank.com/drugs/DB00684 MDM LOOM
http://purl.obolibrary.org/obo/OMIT_0014873 OMIT LOOM
http://purl.bioontology.org/ontology/ATC/J01GB01 ATC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62082 NCIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373548001 SNOMEDCT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D09.408.051.476.600.800 RH-MESH LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0040341 OCHV LOOM
http://purl.bioontology.org/ontology/NDDF/002779 NDDF LOOM
http://purl.bioontology.org/ontology/ATC/S01AA12 ATC LOOM
http://purl.bioontology.org/ontology/CPT/80200 CPT LOOM
http://purl.bioontology.org/ontology/SNMI/C-52580 SNMI LOOM
http://purl.obolibrary.org/obo/NCIT_C62082 BERO LOOM
http://www.phoc.org.cn/pmo/class/PMO_00020961 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/MESH_D014031 BERO LOOM