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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
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| Preferred Name | nitisinone | |
| Synonyms |
2-{[2-nitro-4-(trifluoromethyl)phenyl]carbonyl}cyclohexane-1,3-dione C14H10F3NO5 |
|
| ID |
http://purl.obolibrary.org/obo/dinto_DB00348 |
|
| ATCCode |
A16AX04
|
|
| binds | ||
| CASRN |
104206-65-7
|
|
| DBBrand |
orfadin
|
|
| Definition |
Nitisinone is a synthetic reversible inhibitor of 4-hydroxyphenylpyruvate dioxygenase. It is used in the treatment of hereditary tyrosinemia type 1. It is sold under the brand name Orfadin. [Wikipedia]
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|
| has pharmacological target | ||
| InChI |
InChI=1S/C14H10F3NO5/c15-14(16,17)7-4-5-8(9(6-7)18(22)23)13(21)12-10(19)2-1-3-11(12)20/h4-6,12H,1-3H2
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|
| InChIKey |
InChIKey=OUBCNLGXQFSTLU-UHFFFAOYSA-N
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|
| inhibits | ||
| label |
nitisinone
|
|
| prefixIRI |
obo2:dinto_DB00348
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|
| prefLabel |
nitisinone
|
|
| SMILES |
[O-][N+](=O)C1=C(C=CC(=C1)C(F)(F)F)C(=O)C1C(=O)CCCC1=O
|
|
| Synonym |
2-{[2-nitro-4-(trifluoromethyl)phenyl]carbonyl}cyclohexane-1,3-dione C14H10F3NO5
|
|
| xref |
PharmGKB:PA164777037 Wikipedia:http://en.wikipedia.org/wiki/Nitisinone Drugs.com:http://www.drugs.com/cdi/nitisinone.html National Drug Code Directory:66621-1002-6 ChEBI:50378 ChemSpider:103195 PubChem Substance:46507380 RxList:http://www.rxlist.com/cgi/generic/orfadin.htm PubChem Compound:115355
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|
| subClassOf |
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