The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	terfenadine
Synonyms	1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butan-1-ol C32H41NO2
ID	http://purl.obolibrary.org/obo/dinto_DB00342
ATCCode	R06AX12
binds	http://purl.obolibrary.org/obo/dinto_3187 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_1847 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_1071 http://purl.obolibrary.org/obo/dinto_1005 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_1956
blocks	http://purl.obolibrary.org/obo/dinto_1005 http://purl.obolibrary.org/obo/dinto_1071
CASRN	50679-08-8
DBBrand	triludan terdin allerplus aldaban cyater teldane teldanex terfex seldane
DBSynonym	ternadin
Definition	In the U.S., Terfenadine was superseded by fexofenadine in the 1990s due to the risk of cardiac arrhythmia caused by QT interval prolongation.
has pharmacological target	http://purl.obolibrary.org/obo/dinto_1071
InChI	InChI=1S/C32H41NO2/c1-31(2,3)26-18-16-25(17-19-26)30(34)15-10-22-33-23-20-29(21-24-33)32(35,27-11-6-4-7-12-27)28-13-8-5-9-14-28/h4-9,11-14,16-19,29-30,34-35H,10,15,20-24H2,1-3H3
InChIKey	InChIKey=GUGOEEXESWIERI-UHFFFAOYSA-N
induces	http://purl.obolibrary.org/obo/dinto_0901
inhibits	http://purl.obolibrary.org/obo/dinto_3187 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_1847 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_1221
is metabolised by	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1956
is substrate of	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1956
label	terfenadine
may interact with	http://purl.obolibrary.org/obo/CHEBI_119486 http://purl.obolibrary.org/obo/CHEBI_9948 http://purl.obolibrary.org/obo/CHEBI_119573 http://purl.obolibrary.org/obo/CHEBI_31981 http://purl.obolibrary.org/obo/dinto_DB00902 http://purl.obolibrary.org/obo/dinto_DB01142 http://purl.obolibrary.org/obo/CHEBI_6838 http://purl.obolibrary.org/obo/CHEBI_8028 http://purl.obolibrary.org/obo/dinto_DB00224 http://purl.obolibrary.org/obo/CHEBI_3647 http://purl.obolibrary.org/obo/dinto_DB00196 http://purl.obolibrary.org/obo/CHEBI_499361 http://purl.obolibrary.org/obo/CHEBI_8491 http://purl.obolibrary.org/obo/dinto_DB00344 http://purl.obolibrary.org/obo/CHEBI_101278 http://purl.obolibrary.org/obo/CHEBI_40050 http://purl.obolibrary.org/obo/CHEBI_9711 http://purl.obolibrary.org/obo/dinto_DB01246 http://purl.obolibrary.org/obo/dinto_DB00540 http://purl.obolibrary.org/obo/CHEBI_45951 http://purl.obolibrary.org/obo/CHEBI_47499 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/CHEBI_47780 http://purl.obolibrary.org/obo/CHEBI_63622 http://purl.obolibrary.org/obo/CHEBI_3699 http://purl.obolibrary.org/obo/CHEBI_7494 http://purl.obolibrary.org/obo/CHEBI_6780 http://purl.obolibrary.org/obo/CHEBI_9566 http://purl.obolibrary.org/obo/dinto_DB01167 http://purl.obolibrary.org/obo/CHEBI_63621 http://purl.obolibrary.org/obo/CHEBI_8459 http://purl.obolibrary.org/obo/CHEBI_75984 http://purl.obolibrary.org/obo/CHEBI_5123 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/dinto_DB01361 http://purl.obolibrary.org/obo/dinto_DB00365 http://purl.obolibrary.org/obo/CHEBI_6916 http://purl.obolibrary.org/obo/CHEBI_2401 http://purl.obolibrary.org/obo/CHEBI_5138 http://purl.obolibrary.org/obo/CHEBI_8466 http://purl.obolibrary.org/obo/CHEBI_8461 http://purl.obolibrary.org/obo/CHEBI_3720 http://purl.obolibrary.org/obo/dinto_DB01388 http://purl.obolibrary.org/obo/CHEBI_8435 http://purl.obolibrary.org/obo/CHEBI_3732 http://purl.obolibrary.org/obo/CHEBI_64355 http://purl.obolibrary.org/obo/CHEBI_63628 http://purl.obolibrary.org/obo/CHEBI_28593 http://purl.obolibrary.org/obo/dinto_DB01118 http://purl.obolibrary.org/obo/dinto_DB00199 http://purl.obolibrary.org/obo/dinto_DB00503 http://purl.obolibrary.org/obo/dinto_DB01319 http://purl.obolibrary.org/obo/dinto_DB01369 http://purl.obolibrary.org/obo/CHEBI_31739 http://purl.obolibrary.org/obo/CHEBI_9544 http://purl.obolibrary.org/obo/CHEBI_3061 http://purl.obolibrary.org/obo/CHEBI_4657 http://purl.obolibrary.org/obo/CHEBI_15854 http://purl.obolibrary.org/obo/dinto_DB01026 http://purl.obolibrary.org/obo/CHEBI_8428 http://purl.obolibrary.org/obo/CHEBI_71226 http://purl.obolibrary.org/obo/CHEBI_47781 http://purl.obolibrary.org/obo/CHEBI_9611 http://purl.obolibrary.org/obo/dinto_DB00220 http://purl.obolibrary.org/obo/dinto_DB01208 http://purl.obolibrary.org/obo/dinto_DB00622 http://purl.obolibrary.org/obo/CHEBI_2675 http://purl.obolibrary.org/obo/dinto_DB00976 http://purl.obolibrary.org/obo/CHEBI_2666 http://purl.obolibrary.org/obo/CHEBI_5118
modulates	http://purl.obolibrary.org/obo/dinto_1005 http://purl.obolibrary.org/obo/dinto_1071
prefixIRI	obo2:dinto_DB00342
prefLabel	terfenadine
SMILES	CC(C)(C)C1=CC=C(C=C1)C(O)CCCN1CCC(CC1)C(O)(C1=CC=CC=C1)C1=CC=CC=C1
Synonym	1-(4-tert-butylphenyl)-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butan-1-ol C32H41NO2
xref	BindingDB:50017376 ChemSpider:5212 Drugs Product Database (DPD):1913395 RxList:http://www.rxlist.com/cgi/generic/terfen.htm PharmGKB:PA451619 PubChem Substance:46507007 IUPHAR:2608 Drugs.com:http://www.drugs.com/mtm/terfenadine.html Guide To Pharmacology:2608 PubChem Compound:5405 Wikipedia:http://en.wikipedia.org/wiki/Terfenadine
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_9453	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_9453	CHEBI	LOOM
http://purl.jp/bio/4/id/200906023056228450	IOBC	LOOM
http://purl.bioontology.org/ontology/RXNORM/42330	RXNORM	LOOM
https://go.drugbank.com/drugs/DB00342	MDM	LOOM
http://www.drugbank.ca/drugs/DB00342	FTC	LOOM
http://purl.bioontology.org/ontology/MESH/D016593	MESH	LOOM
http://stirdf.jst.go.jp/id/200907055171856000	IOBC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29494	NCIT	LOOM
http://purl.bioontology.org/ontology/SNMI/C-51050	SNMI	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.115.800	RH-MESH	LOOM
http://www.co-ode.org/ontologies/galen#Terfenadine	GALEN	LOOM
http://purl.bioontology.org/ontology/ATC/R06AX12	ATC	LOOM
http://purl.obolibrary.org/obo/MESH_D016593	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9453	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9453	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9453	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9453	DRON	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003387	LOINC	LOOM
http://doe-generated-ontology.com/OntoAD#C0085173	ONTOAD	LOOM
http://purl.bioontology.org/ontology/LNC/LP18101-3	LOINC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#15478	OCHV	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D016593	RH-MESH	LOOM
http://purl.obolibrary.org/obo/NCIT_C29494	BERO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0085173	OCHV	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.621.855	RH-MESH	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016762	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387089004	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/VANDF/4019295	VANDF	LOOM
http://purl.obolibrary.org/obo/OMIT_0017064	OMIT	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147493	NDFRT	LOOM