loading...| Preferred Name |
isradipine |
|
| Synonyms |
3-methyl 5-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate C19H21N3O5 |
|
| ID |
http://purl.obolibrary.org/obo/dinto_DB00270 |
|
| AHFScode |
24:28.08 |
|
| ATCCode |
C08CA03 |
|
| CASRN |
75695-93-1 |
|
| DBBrand |
clivoten dynacirc cr dynacirc dynacire cr dynacrine lomir dynacire esradin rebriden prescal |
|
| DBSynonym |
isradipin (+/-)-isradipine isrodipine isradipinum [latin] isradipino [spanish] |
|
| Definition |
Isradipine belongs to the dihydropyridine (DHP) class of calcium channel blockers (CCBs), the most widely used class of CCBs. It is structurally related to felodipine, nifedipine, and nimodipine and is the most potent calcium-channel blocking agent of the DHP class. Isradipine binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and arterial smooth muscle cells. It exhibits greater selectivity towards arterial smooth muscle cells owing to alternative splicing of the alpha-1 subunit of the channel and increased prevalence of inactive channels in smooth muscle cells. Isradipine may be used to treat mild to moderate essential hypertension. |
|
| has pharmacological target |
http://purl.obolibrary.org/obo/dinto_2962 http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_3113 http://purl.obolibrary.org/obo/dinto_2260 http://purl.obolibrary.org/obo/dinto_2979 |
|
| InChI |
InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3 |
|
| InChIKey |
InChIKey=HMJIYCCIJYRONP-UHFFFAOYSA-N |
|
| inhibits |
http://purl.obolibrary.org/obo/dinto_2962 http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_3113 http://purl.obolibrary.org/obo/dinto_2260 http://purl.obolibrary.org/obo/dinto_2979 http://purl.obolibrary.org/obo/dinto_0901 |
|
| is metabolised by | ||
| label |
isradipine |
|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_102166 http://purl.obolibrary.org/obo/CHEBI_156095 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/CHEBI_51364 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/CHEBI_10119 http://purl.obolibrary.org/obo/CHEBI_9635 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/CHEBI_63628 http://purl.obolibrary.org/obo/CHEBI_45716 http://purl.obolibrary.org/obo/dinto_DB01369 http://purl.obolibrary.org/obo/CHEBI_195280 |
|
| prefixIRI |
obo2:dinto_DB00270 |
|
| prefLabel |
isradipine |
|
| SMILES |
COC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC2=NON=C12)C(=O)OC(C)C |
|
| Synonym |
3-methyl 5-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate C19H21N3O5 |
|
| xref |
PharmGKB:PA450131 PubChem Substance:46505034 National Drug Code Directory:0173-0784-01 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/dyn1152.shtml Drugs.com:http://www.drugs.com/cdi/isradipine.html ChemSpider:3652 Wikipedia:http://en.wikipedia.org/wiki/Isradipine PubChem Compound:3784 |
|
| subClassOf |