The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	troglitazone
Synonyms	Troglitazone Romglizone 5-(4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolidine-2,4-dione 5-({4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-yl)methoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione (+-)-all-rac-5-(p-((6-Hydroxy-2,5,7,8-tetramethyl-2-chromanyl)methoxy)benzyl)-2,4-thiazolidinedione Rezulin (TN) troglitazona C24H27NO5S troglitazonum troglitazone 5-{4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione
ID	http://purl.obolibrary.org/obo/CHEBI_9753
activates	http://purl.obolibrary.org/obo/dinto_2153
ATCCode	A10BG01
blocks	http://purl.obolibrary.org/obo/dinto_2165
CASRN	97322-87-7
DBBrand	romozin prelay rezulin romglizone noscal resulin
DBname	troglitazone
Definition	A chromane that has formula C24H27NO5S.
has effect	http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2153
has role	http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_22586 http://purl.obolibrary.org/obo/CHEBI_35526 http://purl.obolibrary.org/obo/CHEBI_50427 http://purl.obolibrary.org/obo/CHEBI_35620 http://purl.obolibrary.org/obo/CHEBI_35623 http://purl.obolibrary.org/obo/CHEBI_50249
InChI	InChI=1S/C24H27NO5S/c1-13-14(2)21-18(15(3)20(13)26)9-10-24(4,30-21)12-29-17-7-5-16(6-8-17)11-19-22(27)25-23(28)31-19/h5-8,19,26H,9-12H2,1-4H3,(H,25,27,28)
InChIKey	InChIKey=GXPHKUHSUJUWKP-UHFFFAOYSA-N
induces	http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_0465
inhibits	http://purl.obolibrary.org/obo/dinto_0718 http://purl.obolibrary.org/obo/dinto_3102 http://purl.obolibrary.org/obo/dinto_2026 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_1701 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_2019 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_3489 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_1221
is metabolised by	http://purl.obolibrary.org/obo/dinto_1891 http://purl.obolibrary.org/obo/dinto_1890 http://purl.obolibrary.org/obo/dinto_1892 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_1701 http://purl.obolibrary.org/obo/dinto_1848 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0265 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_1712 http://purl.obolibrary.org/obo/dinto_1711 http://purl.obolibrary.org/obo/dinto_0270 http://purl.obolibrary.org/obo/dinto_0276
label	troglitazone
may interact with	http://purl.obolibrary.org/obo/CHEBI_7627 http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/dinto_DB00977 http://purl.obolibrary.org/obo/dinto_DB01432
prefixIRI	obo2:CHEBI_9753
prefLabel	troglitazone
related with	http://purl.obolibrary.org/obo/dinto_1443 http://purl.obolibrary.org/obo/dinto_3131
SMILES	CC1=C(C)C2=C(CCC(C)(COC3=CC=C(CC4SC(=O)NC4=O)C=C3)O2)C(C)=C1O Cc1c(C)c2OC(C)(CCc2c(C)c1O)COc1ccc(CC2SC(=O)NC2=O)cc1
Synonym	Troglitazone Romglizone 5-(4-(6-Hydroxy-2,5,7,8-tetramethylchroman-2-ylmethoxy)benzyl)thiazolidine-2,4-dione 5-({4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-1-benzopyran-2-yl)methoxy]phenyl}methyl)-1,3-thiazolidine-2,4-dione (+-)-all-rac-5-(p-((6-Hydroxy-2,5,7,8-tetramethyl-2-chromanyl)methoxy)benzyl)-2,4-thiazolidinedione Rezulin (TN) troglitazona C24H27NO5S troglitazonum troglitazone 5-{4-[(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-chromen-2-yl)methoxy]benzyl}-1,3-thiazolidine-2,4-dione
xref	KEGG DRUG:D00395 PharmGKB:PA451799 Guide To Pharmacology:2693 Patent:US4572912 ChEBI:9753 RxList:http://www.rxlist.com/cgi/generic/troglitazone.htm DrugBank:DB00197 CASRN:97322-87-7 Beilstein:4338399 ChEMBL:100666 IUPHAR:2693 Drugs.com:http://www.drugs.com/mtm/troglitazone.html PubChem Compound:5591 Wikipedia:http://en.wikipedia.org/wiki/Troglitazone PubChem Substance:46504655 Wikipedia:Troglitazone ChemSpider:5389
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_9753	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9753	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9753	HOIP	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9753	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9753	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9753	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9753	TXPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9753	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9753	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9753	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9753	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_9753	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9753	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_9753	CHEBI	LOOM
http://purl.obolibrary.org/obo/XCO_0001254	XCO	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148466	NDFRT	LOOM
http://purl.bioontology.org/ontology/NDDF/006355	NDDF	LOOM
http://stirdf.jst.go.jp/id/200907082274309403	IOBC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0245514	OCHV	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C057693	RH-MESH	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386967007	SNOMEDCT	LOOM
http://purl.jp/bio/4/id/200906049155437621	IOBC	LOOM
http://purl.bioontology.org/ontology/MESH/D000077288	MESH	LOOM
http://www.drugbank.ca/drugs/DB00197	FTC	LOOM
http://purl.obolibrary.org/obo/NCIT_C1522	BERO	LOOM
http://purl.bioontology.org/ontology/RCD/ft2..	RCD	LOOM
https://go.drugbank.com/drugs/DB00197	MDM	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#25135	OCHV	LOOM
http://purl.bioontology.org/ontology/RXNORM/72610	RXNORM	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1522	NCIT	LOOM
http://purl.bioontology.org/ontology/VANDF/4020997	VANDF	LOOM
http://purl.bioontology.org/ontology/CSP/4008-0099	CRISP	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042706	PDQ	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025157	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9753	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9753	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9753	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9753	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_9753	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_9753	NIFSTD	LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#troglitazone	SDO	LOOM
http://purl.bioontology.org/ontology/ATC/A10BG01	ATC	LOOM