The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	sulfasalazine
Synonyms	Sulfasalazina 2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid 2-hydroxy-5-{[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl}benzoic acid 4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene Salicylazosulfapyridine 5-((p-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid Sulfasalazine Salazosulfapyridine Salazosulfapiridina 5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid Salazosulfapyridinum Sulfasalazinum sulfasalazine Azulfidine 2-Hydroxy-5-[4-(pyridin-2-ylsulfamoyl)-phenylazo]-benzoic acid 2-hydroxy-5-[(E)-2-{4-[(pyridin-2-yl)sulfamoyl]phenyl}diazen-1-yl]benzoic acid 5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid C18H14N4O5S
ID	http://purl.obolibrary.org/obo/CHEBI_9334
activates	http://purl.obolibrary.org/obo/dinto_2153
AHFScode	08:12.20
altId	CHEBI:101223
ATCCode	A07EC01
binds	http://purl.obolibrary.org/obo/dinto_0893 http://purl.obolibrary.org/obo/dinto_2100 http://purl.obolibrary.org/obo/dinto_0883 http://purl.obolibrary.org/obo/dinto_2005 http://purl.obolibrary.org/obo/dinto_1365 http://purl.obolibrary.org/obo/dinto_0940 http://purl.obolibrary.org/obo/dinto_0938 http://purl.obolibrary.org/obo/dinto_3013 http://purl.obolibrary.org/obo/dinto_2116 http://purl.obolibrary.org/obo/dinto_2153 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0887
CASRN	599-79-1
DBBrand	sulcolon salazosulfapyridine azopyrine w-t sasp oral azopyrin salazopiridazin salicylazosulfapyridine accucol colo-pleon azulfidine en-tabs asulfidine azlufidine en-tabs pms-sulfasalazine reupirin salazopyridin pms-sulfasalazine e.c. salazosulfapyridin azulfidine salazopyrin en-tabs s.a.s. enteric-500 benzosulfa salazopyrin alti-sulfasalazine salisulf
DBname	sulfasalazine
DBSynonym	sulphasalazine sulfasalazin
Definition	An azobenzene consisting of diphenyldiazene having a carboxy substituent at the 4-position, a hydroxy substituent at the 3-position and a 2-pyridylaminosulphonyl substituent at the 4'-position.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000875 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0000549 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0001095 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0001378 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0001026 http://purl.obolibrary.org/obo/OAE_0000287 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000283 http://purl.obolibrary.org/obo/OAE_0001300 http://purl.obolibrary.org/obo/OAE_0001024 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0001057 http://purl.obolibrary.org/obo/OAE_0000434 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0001106 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000341 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000438 http://purl.obolibrary.org/obo/OAE_0001198 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0000917 http://purl.obolibrary.org/obo/OAE_0001209 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0001205 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001030 http://purl.obolibrary.org/obo/OAE_0000565 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000500 http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2100 http://purl.obolibrary.org/obo/dinto_2153 http://purl.obolibrary.org/obo/dinto_0938 http://purl.obolibrary.org/obo/dinto_2116
has role	http://purl.obolibrary.org/obo/CHEBI_55324 http://purl.obolibrary.org/obo/CHEBI_35441 http://purl.obolibrary.org/obo/CHEBI_35475
InChI	InChI=1S/C18H14N4O5S/c23-16-9-6-13(11-15(16)18(24)25)21-20-12-4-7-14(8-5-12)28(26,27)22-17-3-1-2-10-19-17/h1-11,23H,(H,19,22)(H,24,25)/b21-20+
InChIKey	InChIKey=NCEXYHBECQHGNR-QZQOTICOSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_0893 http://purl.obolibrary.org/obo/dinto_2100 http://purl.obolibrary.org/obo/dinto_0883 http://purl.obolibrary.org/obo/dinto_2005 http://purl.obolibrary.org/obo/dinto_1365 http://purl.obolibrary.org/obo/dinto_0940 http://purl.obolibrary.org/obo/dinto_0938 http://purl.obolibrary.org/obo/dinto_3013 http://purl.obolibrary.org/obo/dinto_2116
is metabolised by	http://purl.obolibrary.org/obo/dinto_2990
is substrate of	http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0887 http://purl.obolibrary.org/obo/dinto_0883
is transported by	http://purl.obolibrary.org/obo/dinto_0887 http://purl.obolibrary.org/obo/dinto_0883
label	sulfasalazine
may interact with	http://purl.obolibrary.org/obo/CHEBI_4551 http://purl.obolibrary.org/obo/CHEBI_2948 http://purl.obolibrary.org/obo/CHEBI_3650 http://purl.obolibrary.org/obo/CHEBI_4031 http://purl.obolibrary.org/obo/CHEBI_50667 http://purl.obolibrary.org/obo/CHEBI_68845 http://purl.obolibrary.org/obo/CHEBI_9555
modulates	http://purl.obolibrary.org/obo/dinto_2153
prefixIRI	obo2:CHEBI_9334
prefLabel	sulfasalazine
SMILES	OC(=O)c1cc(ccc1O)\\N=N\\c1ccc(cc1)S(=O)(=O)Nc1ccccn1 OC(=O)C1=CC(=CC=C1O)\N=N\C1=CC=C(C=C1)S(=O)(=O)NC1=NC=CC=C1
Synonym	Sulfasalazina 2-Hydroxy-5-((4-((2-pyridinylamino)sulfonyl)phenyl)azo)benzoic acid 2-hydroxy-5-{[4-(pyridin-2-ylsulfamoyl)phenyl]diazenyl}benzoic acid 4-(Pyridyl-2-amidosulfonyl)-3'-carboxy-4'-hydroxyazobenzene Salicylazosulfapyridine 5-((p-(2-Pyridylsulfamoyl)phenyl)azo)salicylic acid Sulfasalazine Salazosulfapyridine Salazosulfapiridina 5-(4-(2-Pyridylsulfamoyl)phenylazo)-2-hydroxybenzoic acid Salazosulfapyridinum Sulfasalazinum sulfasalazine Azulfidine 2-Hydroxy-5-[4-(pyridin-2-ylsulfamoyl)-phenylazo]-benzoic acid 2-hydroxy-5-[(E)-2-{4-[(pyridin-2-yl)sulfamoyl]phenyl}diazen-1-yl]benzoic acid 5-(p-(2-Pyridylsulfamyl)phenylazo)salicylic acid C18H14N4O5S
xref	ChEBI:9334 CiteXplore:2434548 Gmelin:2666050 Drugs.com:http://www.drugs.com/cdi/sulfasalazine.html National Drug Code Directory:0013-0102-01 KEGG COMPOUND:C07316 ChemSpider:4510284 DrugBank:DB00795 RxList:http://www.rxlist.com/cgi/generic/sulfasal.htm PDB:SAS PubChem Compound:5359476 Beilstein:356241 Drugs Product Database (DPD):685933 PubChem Substance:46505451 Reaxys:8132868 Wikipedia:http://en.wikipedia.org/wiki/Sulfasalazine Beilstein:8132868 CASRN:599-79-1 KEGG DRUG:D00448 Patent:US2396145 PharmGKB:PA451547
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_9334	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9334	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9334	CCONT	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9334	HOIP	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9334	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9334	DOID	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9334	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9334	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9334	HHEAR	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9334	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9334	TXPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9334	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9334	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9334	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9334	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9334	ODNAE	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_9334	OBA	SAME_URI
http://purl.bioontology.org/ontology/ATC/A07EC01	ATC	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146249	NDFRT	LOOM
http://purl.obolibrary.org/obo/ARO_3000698	ARO	LOOM
http://purl.bioontology.org/ontology/NDDF/002832	NDDF	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0036078	OCHV	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000685032	PDQ	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015960	PMAPP-PMO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.590.700.730	RH-MESH	LOOM
http://purl.bioontology.org/ontology/RXNORM/9524	RXNORM	LOOM
http://purl.obolibrary.org/obo/NCIT_C29469	BERO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387248006	SNOMEDCT	LOOM
http://purl.obolibrary.org/obo/CHEBI_9334	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_9334	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9334	CCONT	LOOM
http://purl.obolibrary.org/obo/CHEBI_9334	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_9334	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9334	DOID	LOOM
http://purl.obolibrary.org/obo/CHEBI_9334	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9334	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9334	HHEAR	LOOM
http://purl.obolibrary.org/obo/CHEBI_9334	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_9334	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_9334	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_9334	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_9334	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_9334	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_9334	ODNAE	LOOM
http://purl.obolibrary.org/obo/CHEBI_9334	OBA	LOOM
http://purl.obolibrary.org/obo/OMIT_0013365	OMIT	LOOM
http://purl.obolibrary.org/obo/MESH_D012460	BERO	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU060449	LOINC	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000146249	ODAE	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.065.884.730	RH-MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#11000	OCHV	LOOM
https://go.drugbank.com/drugs/DB00795	MDM	LOOM
http://purl.bioontology.org/ontology/SNMI/C-55960	SNMI	LOOM
http://purl.bioontology.org/ontology/MESH/D012460	MESH	LOOM
http://www.drugbank.ca/drugs/DB00795	FTC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29469	NCIT	LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00470	COID	LOOM
rgo:15240	GAMUTS	LOOM
http://bmi.utah.edu/ontologies/peontology/C0036078	RAO	LOOM
http://purl.bioontology.org/ontology/VANDF/4017897	VANDF	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D012460	RH-MESH	LOOM
http://purl.bioontology.org/ontology/LNC/LP18088-2	LOINC	LOOM