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The Drug-Drug Interactions Ontology
| Preferred Name | teniposide | |
| Synonyms |
C32H32O13S HSDB 6546 teniposide teniposidum 4'-Demethylepipodophyllotoxin-beta-D-thenylidene glucoside VM-26 4'-Demethylepipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside) (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(2-thienylmethylene)-beta-D-glucopyranoside NSC 122819 (10R,11R,15R,16S)-16-{[(4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-(thiophen-2-yl)-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1(9),2,7-trien-12-one teniposido NSC-122819 Vumon |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_75988 |
|
| AHFScode |
10:00.00
|
|
| altId |
CHEBI:9917
|
|
| ATCCode |
L01CB02
|
|
| binds |
http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_2751 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0291 |
|
| CASRN |
29767-20-2
|
|
| DBBrand |
veham-sandoz vumon vee m-26 vehem
|
|
| DBname |
teniposide
|
|
| DBSynonym |
teniposidum [inn-latin] teniposido [inn-spanish]
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|
| Definition |
A furonaphthodioxole that is a synthetic derivative of podophyllotoxin with anti-tumour activity; causes single- and double-stranded breaks in DNA and DNA-protein cross-links and prevents repair by topoisomerase II binding.
|
|
| has effect |
http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001431 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000981 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000752 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0001205 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000394 |
|
| has pharmacological target | ||
| has role | ||
| InChI |
InChI=1S/C32H32O13S/c1-37-19-6-13(7-20(38-2)25(19)33)23-14-8-17-18(42-12-41-17)9-15(14)28(16-10-39-30(36)24(16)23)44-32-27(35)26(34)29-21(43-32)11-40-31(45-29)22-4-3-5-46-22/h3-9,16,21,23-24,26-29,31-35H,10-12H2,1-2H3/t16-,21+,23+,24-,26+,27+,28+,29+,31?,32-/m0/s1
|
|
| InChIKey |
InChIKey=NRUKOCRGYNPUPR-PSZSYXFXSA-N
|
|
| inhibits |
http://purl.obolibrary.org/obo/dinto_2058 |
|
| is metabolised by |
http://purl.obolibrary.org/obo/dinto_2990 |
|
| is substrate of |
http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 |
|
| is transported by | ||
| label |
teniposide
|
|
| prefixIRI |
obo2:CHEBI_75988
|
|
| prefLabel |
teniposide
|
|
| SMILES |
COc1cc(cc(OC)c1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3COC(O[C@H]3[C@H](O)[C@H]2O)c2cccs2)c2cc3OCOc3cc12 [H][C@]12COC(=O)[C@]1([H])[C@H](C1=CC(OC)=C(O)C(OC)=C1)C1=CC3=C(OCO3)C=C1[C@H]2O[C@@H]1O[C@]2([H])COC(O[C@@]2([H])[C@H](O)[C@H]1O)C1=CC=CS1
|
|
| Synonym |
C32H32O13S HSDB 6546 teniposide teniposidum 4'-Demethylepipodophyllotoxin-beta-D-thenylidene glucoside VM-26 4'-Demethylepipodophyllotoxin 9-(4,6-O-2-thenylidene-beta-D-glucopyranoside) (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-(2-thienylmethylene)-beta-D-glucopyranoside NSC 122819 (10R,11R,15R,16S)-16-{[(4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-(thiophen-2-yl)-hexahydro-2H-pyrano[3,2-d][1,3]dioxin-6-yl]oxy}-10-(4-hydroxy-3,5-dimethoxyphenyl)-4,6,13-trioxatetracyclo[7.7.0.0^{3,7}.0^{11,15}]hexadeca-1(9),2,7-trien-12-one teniposido NSC-122819 Vumon
|
|
| xref |
DrugBank:DB00444 CASRN:29767-20-2 RxList:http://www.rxlist.com/cgi/generic2/teniposide.htm CiteXplore:23466610 CiteXplore:21430063 Wikipedia:http://en.wikipedia.org/wiki/Teniposide Drugs Product Database (DPD):588989 KEGG COMPOUND:C11153 KEGG DRUG:D02698 Drugs.com:http://www.drugs.com/cdi/teniposide.html HMDB:HMDB14587 PubChem Substance:46507536 Wikipedia:Teniposide Reaxys:1417328 CiteXplore:21821840 PubChem Compound:34698 PDBeChem:9TP CiteXplore:22846410 ChemSpider:31930 CiteXplore:22644709 CiteXplore:23266449 PharmGKB:PA451611 National Drug Code Directory:0015-3075-19 CiteXplore:23679827 CiteXplore:23838380
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| subClassOf |
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