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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
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| Preferred Name | lomitapide | |
| Synonyms |
lomitapide BMS 201038 N-(2,2,2-trifluoroethyl)-9-{4-[4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidin-1-yl]butyl}-9H-fluorene-9-carboxamide C39H37F6N3O2 AEGR 733 |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_72297 |
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| AHFScode |
24:06.92
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| ATCCode |
C10AX12
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| binds |
http://purl.obolibrary.org/obo/dinto_1440 |
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| blocks | ||
| CASRN |
202914-84-9
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|
| DBBrand |
juxtapid
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|
| DBSalt |
lomitapide mesylate
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| DBSynonym |
bms-201038-04 aegr-773 bms 201038
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| Definition |
A carboxamide obtained by formal condensation of the carboxy group of 4'-(trifluoromethyl)biphenyl-2-carboxylic acid with the primary amino group of 9-[4-(4-aminopiperidin-1-yl)butyl]-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide. Used (as its mesylate salt) as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. Lomitapide is a microsomal triglyceride transfer protein (MTP) inhibitor used in homozygous familial hypercholesterolemia (HoFH) patients. It is marketed under the name Juxtapid.
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| has pharmacological target | ||
| has role | ||
| InChI |
InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)
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| InChIKey |
InChIKey=MBBCVAKAJPKAKM-UHFFFAOYSA-N
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| inhibits | ||
| is metabolised by | ||
| is substrate of | ||
| label |
lomitapide
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|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_68558 http://purl.obolibrary.org/obo/CHEBI_68621 http://purl.obolibrary.org/obo/CHEBI_70746 http://purl.obolibrary.org/obo/CHEBI_9150 http://purl.obolibrary.org/obo/CHEBI_68595 http://purl.obolibrary.org/obo/CHEBI_40303 http://purl.obolibrary.org/obo/CHEBI_100241 http://purl.obolibrary.org/obo/CHEBI_39548 http://purl.obolibrary.org/obo/CHEBI_10033 |
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| modulates | ||
| prefixIRI |
obo2:CHEBI_72297
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|
| prefLabel |
lomitapide
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|
| SMILES |
FC(F)(F)CNC(=O)C1(CCCCN2CCC(CC2)NC(=O)c2ccccc2-c2ccc(cc2)C(F)(F)F)c2ccccc2-c2ccccc12
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| Synonym |
lomitapide BMS 201038 N-(2,2,2-trifluoroethyl)-9-{4-[4-({[4'-(trifluoromethyl)biphenyl-2-yl]carbonyl}amino)piperidin-1-yl]butyl}-9H-fluorene-9-carboxamide C39H37F6N3O2 AEGR 733
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|
| xref |
Patent:US2012035204 Patent:US2010273829 RxList:http://www.rxlist.com/juxtapid-drug.htm ChEMBL:382991 Reaxys:13754976 National Drug Code Directory:76431-110-01 CiteXplore:20127562 Drugs.com:http://www.drugs.com/juxtapid.html Wikipedia:http://en.wikipedia.org/wiki/Lomitapide CiteXplore:23122768 CiteXplore:22963620 Patent:US2008161279 Patent:US2003162788 Wikipedia:Lomitapide Patent:US2011288064 KEGG DRUG:D09637 CiteXplore:23147576 ChEBI:72297 CiteXplore:21846156 Patent:US2012071458 Patent:US2011288110 CASRN:182431-12-5 CiteXplore:23122767
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| subClassOf |
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