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The Drug-Drug Interactions Ontology
| Preferred Name | apixaban | |
| Synonyms |
apixaban 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide BMS 562247-01 apixabanum BMS-562247 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide BMS-562247-01 Eliquis C25H25N5O4 |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_72296 |
|
| AHFScode |
20:12.04.14
|
|
| ATCCode |
B01AF02
|
|
| binds |
http://purl.obolibrary.org/obo/dinto_2145 http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_1847 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1221 |
|
| CASRN |
503612-47-3
|
|
| DBBrand |
eliquis
|
|
| DBname |
apixaban
|
|
| DBSynonym |
bms-562247
|
|
| Definition |
A pyrazolopyridine that is 7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide substituted at position 1 by a 4-methoxyphenyl group and at position 6 by a 4-(2-oxopiperidin-1-yl)phenyl group. It is used for the prevention and treatment of thromboembolic diseases.
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|
| has pharmacological target | ||
| has role | ||
| InChI |
InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)
|
|
| InChIKey |
InChIKey=QNZCBYKSOIHPEH-UHFFFAOYSA-N
|
|
| inhibits | ||
| is metabolised by |
http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_1847 http://purl.obolibrary.org/obo/dinto_0291 |
|
| is substrate of |
http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_1847 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1221 |
|
| is transported by | ||
| label |
apixaban
|
|
| may interact with |
http://purl.obolibrary.org/obo/dinto_DB01225 http://purl.obolibrary.org/obo/CHEBI_70746 http://purl.obolibrary.org/obo/dinto_DB01167 http://purl.obolibrary.org/obo/CHEBI_7476 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/CHEBI_68579 http://purl.obolibrary.org/obo/CHEBI_64355 |
|
| prefixIRI |
obo2:CHEBI_72296
|
|
| prefLabel |
apixaban
|
|
| SMILES |
COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCC1=O COC1=CC=C(C=C1)N1N=C(C(N)=O)C2=C1C(=O)N(CC2)C1=CC=C(C=C1)N1CCCCC1=O
|
|
| Synonym |
apixaban 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide BMS 562247-01 apixabanum BMS-562247 1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide BMS-562247-01 Eliquis C25H25N5O4
|
|
| xref |
KEGG DRUG:D03213 BindingDB:19023 CiteXplore:23218999 CiteXplore:21954450 CiteXplore:23305476 Patent:WO2008031782 CiteXplore:22759198 Patent:WO2010030983 CASRN:503612-47-3 CiteXplore:23337923 Reaxys:11244786 Patent:US2007259913 CiteXplore:23179181 CiteXplore:23033347 Drugs.com:http://www.drugs.com/eliquis.html CiteXplore:23351997 CiteXplore:23043068 CiteXplore:23312927 CiteXplore:21318583 Wikipedia:Apixaban CiteXplore:23344716 CiteXplore:22398784 PubChem Compound:10182969 DrugBank:DB06605 National Drug Code Directory:0003-0894-21 Patent:WO2007022165 RxList:http://www.rxlist.com/eliquis-drug.htm ChEBI:72296 CiteXplore:23342716 PDB:GG2 Wikipedia:http://en.wikipedia.org/wiki/Apixaban CiteXplore:23292264 PDBeChem:GG2 CiteXplore:21985171 CiteXplore:23212107 ChemSpider:8358471 CiteXplore:22250655 CiteXplore:22686618 CiteXplore:23292752
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| subClassOf |
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