The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Preferred Name	procarbazine hydrochloride
Synonyms	procarbazine monohydrochloride C12H19N3O Procarbazine HCl 4-[(2-methylhydrazin-1-yl)methyl]-N-(propan-2-yl)benzamide N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride 1-(p-Isopropylcarbamoylbenzyl)-2-methylhydrazine hydrochloride N-Isopropyl-p-(2-methylhydrazinomethyl)benzamide hydrochloride C12H20ClN3O 1-Methyl-2-p-(isopropylcarbamoyl)benzohydrazine hydrochloride 2-(p-(Isopropylcarbamoyl)benzyl)-1-methylhydrazine hydrochloride N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide hydrochloride 1-Methyl-2-(p-isopropylcarbamoylbenzyl)hydrazine hydrochloride
ID	http://purl.obolibrary.org/obo/CHEBI_71428
AHFScode	10:00.00
altId	CHEBI:8433
ATCCode	L01XB01
binds	http://purl.obolibrary.org/obo/dinto_2873 http://purl.obolibrary.org/obo/dinto_3611 http://purl.obolibrary.org/obo/dinto_0285
CASRN	671-16-9
DBBrand	natulanar natunalar natulan hydrochloride natulan nathulane matulane
DBname	procarbazine
DBSynonym	procarbazin [german] procarbazin procarbazinum [inn-latin] ibenzmethyzin mbh mih hydrochloride procarbazine hydrochloride procarbazina [inn-spanish] pcx ibz pcb hydrochloride ibenzmethyzine ibenzmethyzine hydrochloride mih
Definition	A hydrochloride obtained by combining procarbazine with one equivalent of hydrochloric acid. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0001199 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001259 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0001013 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0001397 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0000943 http://purl.obolibrary.org/obo/OAE_0000671 http://purl.obolibrary.org/obo/OAE_0001003 http://purl.obolibrary.org/obo/OAE_0001374 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000510 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000341 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0001276 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0001152 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000185 http://purl.obolibrary.org/obo/OAE_0000491 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000275 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001291 http://purl.obolibrary.org/obo/OAE_0001001 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0001166 http://purl.obolibrary.org/obo/OAE_0000881 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000257 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0000456 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0001298
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2873
has role	http://purl.obolibrary.org/obo/CHEBI_35610
InChI	InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16) InChI=1S/C12H19N3O.ClH/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3;/h4-7,9,13-14H,8H2,1-3H3,(H,15,16);1H
InChIKey	InChIKey=CPTBDICYNRMXFX-UHFFFAOYSA-N InChIKey=DERJYEZSLHIUKF-UHFFFAOYSA-N
is metabolised by	http://purl.obolibrary.org/obo/dinto_0285
is substrate of	http://purl.obolibrary.org/obo/dinto_0285
label	procarbazine hydrochloride
prefixIRI	obo2:CHEBI_71428
prefLabel	procarbazine hydrochloride
related with	http://purl.obolibrary.org/obo/dinto_2873 http://purl.obolibrary.org/obo/dinto_3611
SMILES	Cl.CNNCc1ccc(cc1)C(=O)NC(C)C CNNCC1=CC=C(C=C1)C(=O)NC(C)C
Synonym	procarbazine monohydrochloride C12H19N3O Procarbazine HCl 4-[(2-methylhydrazin-1-yl)methyl]-N-(propan-2-yl)benzamide N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide hydrochloride 1-(p-Isopropylcarbamoylbenzyl)-2-methylhydrazine hydrochloride N-Isopropyl-p-(2-methylhydrazinomethyl)benzamide hydrochloride C12H20ClN3O 1-Methyl-2-p-(isopropylcarbamoyl)benzohydrazine hydrochloride 2-(p-(Isopropylcarbamoyl)benzyl)-1-methylhydrazine hydrochloride N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide hydrochloride 1-Methyl-2-(p-isopropylcarbamoylbenzyl)hydrazine hydrochloride
xref	CiteXplore:323527 ChEMBL:774361 PubChem Compound:4915 Patent:WO2008100985 KEGG COMPOUND:C07376 CiteXplore:20412004 CASRN:366-70-1 Patent:WO2005072705 CiteXplore:3838228 CiteXplore:16690522 CiteXplore:7416483 PubChem Substance:46507706 CiteXplore:2747729 Patent:GB2480472 CiteXplore:7384804 CiteXplore:792579 CiteXplore:21603918 CiteXplore:62854 CiteXplore:2607014 PharmGKB:PA451112 CiteXplore:713008 CiteXplore:4927302 KEGG DRUG:D00478 CiteXplore:21863086 CiteXplore:1097949 Drugs Product Database (DPD):12750 CiteXplore:7022795 CiteXplore:3185586 CiteXplore:843152 Drugs.com:http://www.drugs.com/cdi/procarbazine.html CiteXplore:3079944 CiteXplore:7380952 Reaxys:4024454 CiteXplore:3687991 RxList:http://www.rxlist.com/cgi/generic3/procarb.htm DrugBank:DB01168 ChemSpider:4746 CiteXplore:1209725 Wikipedia:http://en.wikipedia.org/wiki/Procarbazine CiteXplore:641741
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_71428	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_71428	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_71428	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_71428	CHEBI	LOOM
http://purl.bioontology.org/ontology/SNMI/C-781C1	SNMI	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000146150	NDFRT	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/10174003	SNOMEDCT	LOOM
http://purl.obolibrary.org/obo/NCIT_C773	BERO	LOOM
http://www.co-ode.org/ontologies/galen#ProcarbazineHydrochloride	GALEN	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0205909	OCHV	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000041607	PDQ	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C773	NCIT	LOOM
http://purl.obolibrary.org/obo/CHEBI_71428	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_71428	BERO	LOOM
http://purl.bioontology.org/ontology/VANDF/4017789	VANDF	LOOM
http://purl.bioontology.org/ontology/RXNORM/66925	RXNORM	LOOM