loading...| Preferred Name |
procarbazine |
|
| Synonyms |
N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide C12H19N3O N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide Procarbazin N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide 4-[(2-methylhydrazin-1-yl)methyl]-N-(propan-2-yl)benzamide procarbazine procarbazina N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide procarbazinum 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_71417 |
|
| AHFScode |
10:00.00 |
|
| altId |
CHEBI:8432 |
|
| ATCCode |
L01XB01 |
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| CASRN |
671-16-9 |
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| DBBrand |
natulanar natunalar natulan hydrochloride natulan nathulane matulane |
|
| DBname |
procarbazine |
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| DBSynonym |
procarbazin [german] procarbazin procarbazinum [inn-latin] ibenzmethyzin mbh mih hydrochloride procarbazine hydrochloride procarbazina [inn-spanish] pcx ibz pcb hydrochloride ibenzmethyzine ibenzmethyzine hydrochloride mih |
|
| Definition |
A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands. |
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| has pharmacological target | ||
| has role | ||
| InChI |
InChI=1S/C12H19N3O/c1-9(2)15-12(16)11-6-4-10(5-7-11)8-14-13-3/h4-7,9,13-14H,8H2,1-3H3,(H,15,16) |
|
| InChIKey |
InChIKey=CPTBDICYNRMXFX-UHFFFAOYSA-N |
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| is metabolised by | ||
| label |
procarbazine |
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| prefixIRI |
obo2:CHEBI_71417 |
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| prefLabel |
procarbazine |
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| related with | ||
| SMILES |
CNNCC1=CC=C(C=C1)C(=O)NC(C)C CNNCc1ccc(cc1)C(=O)NC(C)C |
|
| Synonym |
N-Isopropyl-alpha-(2-methylhydrazino)-p-toluamide C12H19N3O N-(1-Methylethyl)-4-((2-methylhydrazino)methyl)benzamide Procarbazin N-4-Isopropylcarbamoylbenzyl-N'-methylhydrazine N-isopropyl-4-[(2-methylhydrazino)methyl]benzamide 4-((2-Methylhydrazino)methyl)-N-isopropylbenzamide 4-[(2-methylhydrazin-1-yl)methyl]-N-(propan-2-yl)benzamide procarbazine procarbazina N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide procarbazinum 2-(p-Isopropylcarbamoylbenzyl)-1-methylhydrazine p-(2-Methylhydrazinomethyl)-N-isopropylbenzamide N-Isopropyl-p-(2-methylhydrazinomethyl)-benzamide 1-Methyl-2-(p-(isopropylcarbamoyl)benzyl)hydrazine |
|
| xref |
CiteXplore:21703849 CiteXplore:22423248 Patent:US3830840 CiteXplore:23071237 ChEMBL:366225 PubChem Compound:4915 NIST Chemistry WebBook:671-16-9 HMDB:HMDB15299 CASRN:671-16-9 Patent:US3520926 CiteXplore:22708037 PubChem Substance:46507706 Patent:US2008107661 CiteXplore:21870118 CiteXplore:21740300 PharmGKB:PA451112 CiteXplore:22851558 CiteXplore:22744756 KEGG COMPOUND:C07402 Patent:US2007122414 Drugs Product Database (DPD):12750 Drugs.com:http://www.drugs.com/cdi/procarbazine.html CiteXplore:22913972 Wikipedia:Procarbazine RxList:http://www.rxlist.com/cgi/generic3/procarb.htm DrugBank:DB01168 CiteXplore:21420247 ChemSpider:4746 KEGG DRUG:D08423 Patent:BE618638 Wikipedia:http://en.wikipedia.org/wiki/Procarbazine Reaxys:958270 |
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| subClassOf |