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The Drug-Drug Interactions Ontology
| Preferred Name | saxagliptin | |
| Synonyms |
BMS-477118 C18H25N3O2 (1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile BMS 477118 (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile saxagliptin |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_71272 |
|
| AHFScode |
68:20.05
|
|
| ATCCode |
A10BH03
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|
| binds |
http://purl.obolibrary.org/obo/dinto_2272 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1805 |
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| CASRN |
361442-04-8
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|
| DBBrand |
onglyza
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|
| DBSalt |
saxagliptin hydrochloride
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|
| DBSynonym |
bms-477118 onglyza
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|
| Definition |
A carboxamide obtained by formal condensation of the carboxy group of (2S)-amino(3-hydroxyadamantan-1-yl)acetic acid with the amino group of (1S,3S,5S)-2-azabicyclo[3.1.0]hexane-3-carbonitrile. Used in its monohydrate form for the treatment of Type II diabetes. Saxagliptin (rINN) is an orally active hypoglycemic (anti-diabetic drug) of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. FDA approved on July 31, 2009.
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|
| has effect |
http://purl.obolibrary.org/obo/OAE_0000496 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0001154 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0001057 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000336 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0000618 http://purl.obolibrary.org/obo/OAE_0001366 |
|
| has pharmacological target | ||
| has role | ||
| InChI |
InChI=1S/C18H25N3O2/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17/h10-15,23H,1-7,9,20H2/t10?,11?,12-,13+,14+,15-,17?,18?/m1/s1
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|
| InChIKey |
InChIKey=QGJUIPDUBHWZPV-SGTAVMJGSA-N
|
|
| inhibits | ||
| is metabolised by | ||
| is substrate of |
http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1805 |
|
| is transported by |
http://purl.obolibrary.org/obo/dinto_1805 |
|
| label |
saxagliptin
|
|
| may interact with |
http://purl.obolibrary.org/obo/dinto_DB00224 http://purl.obolibrary.org/obo/CHEBI_101278 http://purl.obolibrary.org/obo/CHEBI_9150 http://purl.obolibrary.org/obo/CHEBI_7494 http://purl.obolibrary.org/obo/CHEBI_681850 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/CHEBI_3732 http://purl.obolibrary.org/obo/dinto_DB00052 http://purl.obolibrary.org/obo/dinto_DB00199 http://purl.obolibrary.org/obo/dinto_DB00503 http://purl.obolibrary.org/obo/dinto_DB01026 |
|
| prefixIRI |
obo2:CHEBI_71272
|
|
| prefLabel |
saxagliptin
|
|
| SMILES |
N[C@H](C(=O)N1[C@H]2C[C@H]2C[C@H]1C#N)C12CC3CC(CC(O)(C3)C1)C2 [H][C@]12C[C@@H](C#N)N(C(=O)[C@@H](N)C34CC5CC(CC(O)(C5)C3)C4)[C@@]1([H])C2
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|
| Synonym |
BMS-477118 C18H25N3O2 (1S,3S,5S)-2-((2S)-Amino(3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile BMS 477118 (1S,3S,5S)-2-[(2S)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile saxagliptin
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|
| xref |
ChEMBL:460723 CiteXplore:22192246 CiteXplore:22001114 CiteXplore:22248301 CiteXplore:22475049 PharmGKB:PA165958362 CiteXplore:22098472 CiteXplore:22221000 CiteXplore:22349123 Wikipedia:http://en.wikipedia.org/wiki/Saxagliptin CASRN:361442-04-8 DrugBank:DB06335 CiteXplore:22066527 CiteXplore:22313154 KEGG DRUG:D08996 CiteXplore:22932707 CiteXplore:22823746 CiteXplore:22943617 CiteXplore:22149373 CiteXplore:22132773 Patent:WO2011125011 CiteXplore:22313172 Reaxys:10201614 Wikipedia:Saxagliptin CiteXplore:23137182 CiteXplore:22292415 ChEBI:618213 RxList:http://www.rxlist.com/onglyza-drug.htm Patent:US2005222242 CiteXplore:22668067 National Drug Code Directory:0003-4215-11 CiteXplore:22081481 CiteXplore:22232748 Patent:US2007172525 CiteXplore:22828124 PubChem Substance:99443245 CiteXplore:22776778 Patent:WO2007078726 Drugs.com:http://www.drugs.com/international/saxagliptin.html PubChem Compound:11243969 ChemSpider:9419005 CiteXplore:22496391 HMDB:HMDB15634 Patent:WO2009022009 CiteXplore:22334441 CiteXplore:22564773
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| subClassOf |
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