The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

pazopanib
Synonyms

GW786034

GW 78603

C21H23N7O2S

5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide

5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide

pazopanibum

pazopanib

ID

http://purl.obolibrary.org/obo/CHEBI_71219

AHFScode

10:00

ATCCode

L01XE11

binds

http://purl.obolibrary.org/obo/dinto_0920

http://purl.obolibrary.org/obo/dinto_0552

http://purl.obolibrary.org/obo/dinto_1681

http://purl.obolibrary.org/obo/dinto_2997

http://purl.obolibrary.org/obo/dinto_2271

http://purl.obolibrary.org/obo/dinto_2019

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_0376

http://purl.obolibrary.org/obo/dinto_2464

http://purl.obolibrary.org/obo/dinto_3506

http://purl.obolibrary.org/obo/dinto_0276

http://purl.obolibrary.org/obo/dinto_1752

http://purl.obolibrary.org/obo/dinto_0912

http://purl.obolibrary.org/obo/dinto_2651

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_1221

http://purl.obolibrary.org/obo/dinto_0883

http://purl.obolibrary.org/obo/dinto_1440

CASRN

444731-52-6

DBBrand

votrient

DBSalt

pazopanib hydrochloride

DBSynonym

gw-786034

gw786034

Definition

Pazopanib is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. It is developed by GlaxoSmithKline and was FDA approved on October 19, 2009.

A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.

has pharmacological target

http://purl.obolibrary.org/obo/dinto_0920

http://purl.obolibrary.org/obo/dinto_0552

http://purl.obolibrary.org/obo/dinto_1681

http://purl.obolibrary.org/obo/dinto_0912

http://purl.obolibrary.org/obo/dinto_2271

http://purl.obolibrary.org/obo/dinto_0376

has role

http://purl.obolibrary.org/obo/CHEBI_35610

http://purl.obolibrary.org/obo/CHEBI_38637

http://purl.obolibrary.org/obo/CHEBI_65207

http://purl.obolibrary.org/obo/CHEBI_67170

InChI

InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)

InChIKey

InChIKey=CUIHSIWYWATEQL-UHFFFAOYSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_0920

http://purl.obolibrary.org/obo/dinto_0552

http://purl.obolibrary.org/obo/dinto_1681

http://purl.obolibrary.org/obo/dinto_2997

http://purl.obolibrary.org/obo/dinto_2271

http://purl.obolibrary.org/obo/dinto_2019

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_0376

http://purl.obolibrary.org/obo/dinto_2464

http://purl.obolibrary.org/obo/dinto_3506

http://purl.obolibrary.org/obo/dinto_0276

http://purl.obolibrary.org/obo/dinto_1752

is metabolised by

http://purl.obolibrary.org/obo/dinto_2651

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_1221

is substrate of

http://purl.obolibrary.org/obo/dinto_2651

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_1221

http://purl.obolibrary.org/obo/dinto_0883

http://purl.obolibrary.org/obo/dinto_1440

is transported by

http://purl.obolibrary.org/obo/dinto_0883

http://purl.obolibrary.org/obo/dinto_1440

label

pazopanib

may interact with

http://purl.obolibrary.org/obo/CHEBI_5864

http://purl.obolibrary.org/obo/CHEBI_45863

http://purl.obolibrary.org/obo/CHEBI_66901

http://purl.obolibrary.org/obo/CHEBI_156095

http://purl.obolibrary.org/obo/CHEBI_9150

http://purl.obolibrary.org/obo/CHEBI_49603

http://purl.obolibrary.org/obo/CHEBI_3699

http://purl.obolibrary.org/obo/CHEBI_7494

http://purl.obolibrary.org/obo/CHEBI_51364

http://purl.obolibrary.org/obo/dinto_DB01167

http://purl.obolibrary.org/obo/CHEBI_63621

http://purl.obolibrary.org/obo/CHEBI_681850

http://purl.obolibrary.org/obo/dinto_DB00904

http://purl.obolibrary.org/obo/CHEBI_10119

http://purl.obolibrary.org/obo/CHEBI_3387

http://purl.obolibrary.org/obo/CHEBI_9635

http://purl.obolibrary.org/obo/CHEBI_3732

http://purl.obolibrary.org/obo/CHEBI_45367

http://purl.obolibrary.org/obo/dinto_DB00762

http://purl.obolibrary.org/obo/dinto_DB00199

http://purl.obolibrary.org/obo/dinto_DB00503

http://purl.obolibrary.org/obo/dinto_DB01026

http://purl.obolibrary.org/obo/CHEBI_28077

http://purl.obolibrary.org/obo/CHEBI_195280

prefixIRI

obo2:CHEBI_71219

prefLabel

pazopanib

related with

http://purl.obolibrary.org/obo/dinto_0912

SMILES

CN(C1=CC2=NN(C)C(C)=C2C=C1)C1=CC=NC(NC2=CC=C(C)C(=C2)S(N)(=O)=O)=N1

CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1

Synonym

GW786034

GW 78603

C21H23N7O2S

5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide

5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzene-1-sulfonamide

pazopanibum

pazopanib

xref

CiteXplore:22766517

CiteXplore:22359392

CiteXplore:22688250

CiteXplore:23088634

CiteXplore:22716487

CiteXplore:23072642

Patent:US2008293691

CiteXplore:22984765

CiteXplore:22190407

Reaxys:11646488

CiteXplore:23135778

CiteXplore:22233389

Patent:WO2007064753

Patent:WO2011058179

National Drug Code Directory:0173-0804-09

Wikipedia:Pazopanib

CiteXplore:22112314

Patent:WO2011150044

CiteXplore:23054212

Patent:WO2007143483

Wikipedia:http://en.wikipedia.org/wiki/Pazopanib

CiteXplore:22679111

CiteXplore:22759480

Patent:WO2011069053

RxList:http://www.rxlist.com/votrient-drug.htm

ChEMBL:589525

CiteXplore:22733110

CiteXplore:23064954

Patent:WO2012106302

Drugs.com:http://www.drugs.com/cdi/pazopanib.html

ChEBI:71219

Patent:WO2006020564

CiteXplore:22917595

CiteXplore:21766486

CASRN:444731-52-6

CiteXplore:22733795

CiteXplore:22595799

CiteXplore:22861374

CiteXplore:22830347

CiteXplore:22341567

CiteXplore:21811833

CiteXplore:21394443

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_71219 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_71219 FIDEO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_71219 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_71219 HOIP SAME_URI
http://purl.obolibrary.org/obo/CHEBI_71219 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_71219 EFO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_71219 DDSS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_71219 TXPO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_71219 CIDO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_71219 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_71219 OBA SAME_URI
http://purl.obolibrary.org/obo/CHEBI_71219 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 HOIP LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 TXPO LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 CIDO LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_71219 OBA LOOM
http://purl.bioontology.org/ontology/RXNORM/714438 RXNORM LOOM
http://stirdf.jst.go.jp/id/200907077493609206 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/C516667 MESH LOOM
http://purl.bioontology.org/ontology/ATC/L01EX03 ATC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C74547 NCIT LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026228 PMAPP-PMO LOOM
https://go.drugbank.com/drugs/DB06589 MDM LOOM
http://purl.bioontology.org/ontology/LNC/LP437060-9 LOINC LOOM
http://purl.obolibrary.org/obo/NCIT_C74547 BERO LOOM
http://purl.bioontology.org/ontology/NDDF/013302 NDDF LOOM
http://purl.jp/bio/4/id/201106027485379533 IOBC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C516667 RH-MESH LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/443763005 SNOMEDCT LOOM
http://purl.bioontology.org/ontology/LNC/MTHU069574 LOINC LOOM
http://www.semanticweb.org/hx-jta/ontologies/thyroid_cancer_ontology#Pazopanib TCO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000180309 NDFRT LOOM
http://www.drugbank.ca/drugs/DB06589 FTC LOOM
http://purl.bioontology.org/ontology/VANDF/4029464 VANDF LOOM