The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	mexiletine
Synonyms	mexiletine 1-(2,6-dimethylphenoxy)-2-propanamine 2-(2-aminopropoxy)-1,3-dimethylbenzene mexiletina 1-methyl-2-(2,6-xylyloxy)ethanamine 1-(2,6-dimethylphenoxy)propan-2-amine 1-(2',6'-dimethylphenoxy)-2-aminopropane mexiletinum Mexiletine (+-)-1-(2,6-dimethylphenoxy)propan-2-amine (2RS)-1-(2,6-dimethylphenoxy)-2-aminopropane C11H17NO
ID	http://purl.obolibrary.org/obo/CHEBI_6916
activates	http://purl.obolibrary.org/obo/dinto_1446
AHFScode	24:04.04.08
altId	CHEBI:115958
ATCCode	C01BB02
binds	http://purl.obolibrary.org/obo/dinto_1670 http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_1446 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0465
CASRN	31828-71-4
DBBrand	mexitil
DBname	mexiletine
DBSynonym	mexiletine hcl mexilitine mexiletina [inn-spanish] mexiletinum [inn-latin]
Definition	Mexiletine is an aromatic ether, being the 2,6-dimethylphenyl ether of 2-aminopropan-1-ol.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0001297 http://purl.obolibrary.org/obo/OAE_0001199 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000050 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0001341 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000894 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0001484 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0001145 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0001336 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001030 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target	http://purl.obolibrary.org/obo/dinto_1670
has role	http://purl.obolibrary.org/obo/CHEBI_38070
InChI	InChI=1S/C11H17NO/c1-8-5-4-6-9(2)11(8)13-7-10(3)12/h4-6,10H,7,12H2,1-3H3
InChIKey	InChIKey=VLPIATFUUWWMKC-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_1670 http://purl.obolibrary.org/obo/dinto_2651
is metabolised by	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0465
is substrate of	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0465
label	mexiletine
may interact with	http://purl.obolibrary.org/obo/dinto_DB01303 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/CHEBI_4888 http://purl.obolibrary.org/obo/dinto_DB01223 http://purl.obolibrary.org/obo/dinto_DB00857 http://purl.obolibrary.org/obo/dinto_DB00532 http://purl.obolibrary.org/obo/dinto_DB00342 http://purl.obolibrary.org/obo/dinto_DB00980 http://purl.obolibrary.org/obo/CHEBI_5138 http://purl.obolibrary.org/obo/CHEBI_4728 http://purl.obolibrary.org/obo/CHEBI_8466 http://purl.obolibrary.org/obo/CHEBI_63629 http://purl.obolibrary.org/obo/dinto_DB00382 http://purl.obolibrary.org/obo/CHEBI_70707 http://purl.obolibrary.org/obo/dinto_DB01320 http://purl.obolibrary.org/obo/CHEBI_28177 http://purl.obolibrary.org/obo/CHEBI_28077 http://purl.obolibrary.org/obo/dinto_DB06210 http://purl.obolibrary.org/obo/dinto_DB01623
modulates	http://purl.obolibrary.org/obo/dinto_1446
prefixIRI	obo2:CHEBI_6916
prefLabel	mexiletine
SMILES	CC(N)COc1c(C)cccc1C CC(N)COC1=C(C)C=CC=C1C
Synonym	mexiletine 1-(2,6-dimethylphenoxy)-2-propanamine 2-(2-aminopropoxy)-1,3-dimethylbenzene mexiletina 1-methyl-2-(2,6-xylyloxy)ethanamine 1-(2,6-dimethylphenoxy)propan-2-amine 1-(2',6'-dimethylphenoxy)-2-aminopropane mexiletinum Mexiletine (+-)-1-(2,6-dimethylphenoxy)propan-2-amine (2RS)-1-(2,6-dimethylphenoxy)-2-aminopropane C11H17NO
xref	Wikipedia:http://en.wikipedia.org/wiki/Mexiletine KEGG COMPOUND:C07220 PharmGKB:PA450488 Patent:FR1551055 Reaxys:2092205 Wikipedia:Mexiletine Drugs.com:http://www.drugs.com/cdi/mexiletine.html NIST Chemistry WebBook:31828-71-4 IUPHAR:2629 Guide To Pharmacology:2629 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/mex1261.shtml Patent:US3954872 ChEBI:6916 PubChem Compound:4178 BindingDB:50117271 PubChem Substance:46505491 National Drug Code Directory:0597-0068-01 ChemSpider:4034 KEGG DRUG:D08215 RxList:http://www.rxlist.com/cgi/generic3/mexiletine.htm CASRN:31828-71-4 DrugBank:DB00379 Drugs Product Database (DPD):2230359
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_6916	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6916	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6916	HOIP	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6916	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6916	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6916	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6916	TXPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6916	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6916	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6916	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_6916	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6916	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_6916	CHEBI	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62047	NCIT	LOOM
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClasse25053f3_e50e_4489_82e1_86052ce77fa7	WWECA	LOOM
http://stirdf.jst.go.jp/id/200907012178932363	IOBC	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372909002	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/MESH/D008801	MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.831.500	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008801	RH-MESH	LOOM
http://purl.obolibrary.org/obo/MESH_D008801	BERO	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016219	PMAPP-PMO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0025887	OCHV	LOOM
http://www.drugbank.ca/drugs/DB00379	FTC	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147925	NDFRT	LOOM
http://purl.obolibrary.org/obo/OMIT_0009856	OMIT	LOOM
http://purl.bioontology.org/ontology/LNC/LP16205-4	LOINC	LOOM
http://www.co-ode.org/ontologies/galen#Mexiletine	GALEN	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147925	OCVDAE	LOOM
http://purl.obolibrary.org/obo/CHEBI_6916	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6916	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6916	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6916	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_6916	DRON	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.657.654.675	RH-MESH	LOOM
http://purl.bioontology.org/ontology/SNMI/C-804B0	SNMI	LOOM
http://purl.obolibrary.org/obo/NCIT_C62047	BERO	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU004263	LOINC	LOOM
http://purl.bioontology.org/ontology/ATC/C01BB02	ATC	LOOM
http://purl.bioontology.org/ontology/RCD/x01QK	RCD	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#8079	OCHV	LOOM
http://purl.bioontology.org/ontology/VANDF/4019837	VANDF	LOOM
http://purl.bioontology.org/ontology/CSP/4008-0065	CRISP	LOOM
https://go.drugbank.com/drugs/DB00379	MDM	LOOM
http://purl.jp/bio/4/id/200906080335665490	IOBC	LOOM
http://purl.bioontology.org/ontology/RXNORM/6926	RXNORM	LOOM