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The Drug-Drug Interactions Ontology
Last uploaded:
February 11, 2016
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| Preferred Name | linagliptin | |
| Synonyms |
Tradjenta (R)-8-(3-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methylquinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione 8-[(3R)-3-aminopiperidin-1-yl]-7-(but-2-yn-1-yl)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-2,3,6,7-tetrahydro-1H-purine-2,6-dione BI 1356 8-[(3R)-3-aminopiperidin-1-yl]-7-(but-2-yn-1-yl)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione C25H28N8O2 linagliptin |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_68610 |
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| AHFScode |
68:20.05
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| ATCCode |
A10BH05
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| binds |
http://purl.obolibrary.org/obo/dinto_2272 |
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| CASRN |
668270-12-0
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| DBBrand |
tradjenta
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| DBSynonym |
bi-1356 trajenta
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| Definition |
A xanthine that is 7H-xanthine bearing (4-methylquinazolin-2-yl)methyl, methyl, but-2-yn-1-yl and 3-aminopiperidin-1-yl substituents at positions 1, 3, 7 and 8 respectively (the R-enantiomer). Used for treatment of type II diabetes. Linagliptin is a DPP-4 inhibitor developed by Boehringer Ingelheim for the treatment of type II diabetes [Wikipedia]. Two pharmacological characteristics that sets linagliptin apart from other DPP-4 inhibitors is that it has a non-linear pharmacokinetic profile and is not primarily eliminated by the renal system. FDA approved on May 2, 2011.
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| has pharmacological target | ||
| has role | ||
| InChI |
InChI=1S/C25H28N8O2/c1-4-5-13-32-21-22(29-24(32)31-12-8-9-17(26)14-31)30(3)25(35)33(23(21)34)15-20-27-16(2)18-10-6-7-11-19(18)28-20/h6-7,10-11,17H,8-9,12-15,26H2,1-3H3/t17-/m1/s1
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| InChIKey |
InChIKey=LTXREWYXXSTFRX-QGZVFWFLSA-N
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| inhibits | ||
| is substrate of | ||
| is transported by | ||
| label |
linagliptin
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| may interact with |
http://purl.obolibrary.org/obo/CHEBI_8382 http://purl.obolibrary.org/obo/CHEBI_17650 http://purl.obolibrary.org/obo/CHEBI_3387 |
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| prefixIRI |
obo2:CHEBI_68610
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| prefLabel |
linagliptin
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| SMILES |
CC#CCN1C(=NC2=C1C(=O)N(CC1=NC3=C(C=CC=C3)C(C)=N1)C(=O)N2C)N1CCC[C@@H](N)C1 CC#CCn1c(nc2n(C)c(=O)n(Cc3nc(C)c4ccccc4n3)c(=O)c12)N1CCC[C@@H](N)C1
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| Synonym |
Tradjenta (R)-8-(3-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methylquinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione 8-[(3R)-3-aminopiperidin-1-yl]-7-(but-2-yn-1-yl)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-2,3,6,7-tetrahydro-1H-purine-2,6-dione BI 1356 8-[(3R)-3-aminopiperidin-1-yl]-7-(but-2-yn-1-yl)-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-dione C25H28N8O2 linagliptin
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| xref |
CiteXplore:21723606 CiteXplore:20160157 CiteXplore:21681003 CiteXplore:21340661 CiteXplore:22346314 CiteXplore:22986920 CiteXplore:22691164 Wikipedia:Linagliptin CiteXplore:22804249 CiteXplore:22177783 CiteXplore:21603986 CiteXplore:22879795 CiteXplore:20875371 CiteXplore:22974280 CiteXplore:22748821 CiteXplore:22242621 CiteXplore:20538719 KEGG DRUG:D09566 CiteXplore:22149370 PDBeChem:356 CiteXplore:22761701 CiteXplore:21410628 CiteXplore:20497745 CiteXplore:22234149 CiteXplore:21672124 CiteXplore:22939034 CiteXplore:22651241 Patent:WO2010072776 National Drug Code Directory:0597-0146-60 CiteXplore:22022857 CiteXplore:22816729 CiteXplore:22420306 Patent:US2012165525 CiteXplore:22761275 CiteXplore:21701440 CiteXplore:21205122 CiteXplore:21642558 CiteXplore:21913883 Patent:US2007259900 CiteXplore:22587735 CiteXplore:19947894 CiteXplore:19777398 CiteXplore:22217485 CiteXplore:22356132 CiteXplore:22143285 CiteXplore:19552619 CiteXplore:21781152 CiteXplore:21714581 CiteXplore:21059094 CiteXplore:21114605 CiteXplore:22493041 CiteXplore:20637971 CiteXplore:19476474 CiteXplore:21752782 CiteXplore:22198311 CiteXplore:22440191 CiteXplore:21803422 CiteXplore:22145698 CiteXplore:22913735 ChEBI:68610 CiteXplore:19771584 CiteXplore:21084763 CiteXplore:21053992 CiteXplore:21352464 Patent:WO2006048427 CiteXplore:21680988 CiteXplore:22318932 CiteXplore:22482239 CiteXplore:22541836 CiteXplore:19732457 CiteXplore:22498683 Drugs.com:http://www.drugs.com/cdi/linagliptin.html CiteXplore:22568694 Patent:EP246874 Patent:EP1852108 CASRN:668270-12-0 CiteXplore:22997980 Wikipedia:http://en.wikipedia.org/wiki/Linagliptin CiteXplore:21916836 CiteXplore:21443284 CiteXplore:20086031 Patent:WO2004018468 CiteXplore:21543033 CiteXplore:22926098 CiteXplore:21883034 Patent:WO2009022008 RxList:http://www.rxlist.com/tradjenta-drug.htm CiteXplore:21306414 CiteXplore:22340363 Reaxys:11300181 CiteXplore:22268497 CiteXplore:23033241
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