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The Drug-Drug Interactions Ontology
| Preferred Name | rivaroxaban | |
| Synonyms |
Xarelto C19H18ClN3O5S 5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide rivaroxaban BAY 59-7939 BAY59-7939 |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_68579 |
|
| AHFScode |
20.12.04.14
|
|
| ATCCode |
B01AF01
|
|
| binds |
http://purl.obolibrary.org/obo/dinto_2145 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_1847 |
|
| blocks | ||
| CASRN |
366789-02-8
|
|
| DBBrand |
xarelto
|
|
| DBname |
rivaroxaban
|
|
| DBSynonym |
bay 59-7939
|
|
| Definition |
A carboxamide obtained by formal condensation of the carboxy group of 5-chlorothiophene-2-carboxylic acid with the amino group of 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one. An anticoagulant used for prophylaxis of venous thromboembolism in patients with knee or hip replacement surgery.
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|
| has effect |
http://purl.obolibrary.org/obo/OAE_0000303 http://purl.obolibrary.org/obo/OAE_0000839 http://purl.obolibrary.org/obo/OAE_0000650 http://purl.obolibrary.org/obo/OAE_0000801 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000476 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001429 http://purl.obolibrary.org/obo/OAE_0000022 http://purl.obolibrary.org/obo/OAE_0000468 |
|
| has pharmacological target | ||
| has role | ||
| InChI |
InChI=1S/C19H18ClN3O5S/c20-16-6-5-15(29-16)18(25)21-9-14-10-23(19(26)28-14)13-3-1-12(2-4-13)22-7-8-27-11-17(22)24/h1-6,14H,7-11H2,(H,21,25)/t14-/m0/s1
|
|
| InChIKey |
InChIKey=KGFYHTZWPPHNLQ-AWEZNQCLSA-N
|
|
| is metabolised by |
http://purl.obolibrary.org/obo/dinto_2990 |
|
| is substrate of |
http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_1847 |
|
| is transported by | ||
| label |
rivaroxaban
|
|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_41774 http://purl.obolibrary.org/obo/CHEBI_70746 http://purl.obolibrary.org/obo/dinto_DB01167 http://purl.obolibrary.org/obo/CHEBI_681850 http://purl.obolibrary.org/obo/CHEBI_72296 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/CHEBI_64355 http://purl.obolibrary.org/obo/CHEBI_37941 http://purl.obolibrary.org/obo/dinto_DB00503 http://purl.obolibrary.org/obo/CHEBI_59173 http://purl.obolibrary.org/obo/dinto_DB01026 |
|
| modulates | ||
| prefixIRI |
obo2:CHEBI_68579
|
|
| prefLabel |
rivaroxaban
|
|
| SMILES |
[H][C@]1(CNC(=O)c2ccc(Cl)s2)CN(C(=O)O1)c1ccc(cc1)N1CCOCC1=O ClC1=CC=C(S1)C(=O)NC[C@H]1CN(C(=O)O1)C1=CC=C(C=C1)N1CCOCC1=O
|
|
| Synonym |
Xarelto C19H18ClN3O5S 5-chloro-N-{[(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl}thiophene-2-carboxamide 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide rivaroxaban BAY 59-7939 BAY59-7939
|
|
| xref |
National Drug Code Directory:50458-579-10 CiteXplore:22042412 CiteXplore:22884545 CiteXplore:22958812 CiteXplore:22187012 CiteXplore:22542983 CiteXplore:22871192 CiteXplore:22422332 Wikipedia:Rivaroxaban Patent:US2011034453 CiteXplore:22534269 CiteXplore:22387577 ChEBI:68579 Wikipedia:http://en.wikipedia.org/wiki/Rivaroxaban CASRN:366789-02-8 Patent:US2011288294 CiteXplore:22173426 CiteXplore:22651881 CiteXplore:22777255 CiteXplore:22242932 Reaxys:10206739 Patent:WO2004060887 Patent:EP1685841 CiteXplore:22533680 CiteXplore:22701330 CiteXplore:23014816 CiteXplore:22800431 CiteXplore:23006523 CiteXplore:22740145 CiteXplore:22272729 Patent:US2005182055 Patent:US2009036504 Patent:US2010151011 Patent:WO2008140220 Patent:WO2012035057 CiteXplore:22811404 Patent:WO2005068456 CiteXplore:22932305 Patent:US2007026065 Patent:US2011152266 CiteXplore:22372178 Patent:WO2011080341 PDBeChem:RIV Drugs.com:http://www.drugs.com/cdi/rivaroxaban.html CiteXplore:22534775 ChEMBL:428601 CiteXplore:22664783 Patent:US2011112083 DrugBank:DB06228 RxList:http://www.rxlist.com/xarelto-drug.htm Patent:WO2012051692 KEGG DRUG:D07086 Patent:US7816355
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| subClassOf |
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