loading...| Preferred Name | doxapram | |
| Synonyms |
(+-)-doxapram 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone C24H30N2O2 Doxapram 1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one doxapram |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_681848 |
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| ATCCode |
R07AB01 |
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| binds | ||
| CASRN |
309-29-5 |
|
| DBBrand |
stimulexin doxapram hydrochloride doxapram hcl dopram |
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| DBname |
doxapram |
|
| Definition |
A member of the class of pyrrolidin-2-ones that is N-ethylpyrrolidin-2-one in which both of the hydrogens at the 3 position (adjacent to the carbonyl group) are substituted by phenyl groups, and one of the hydrogens at the 4 position is substituted by a 2-(morpholin-4-yl)ethyl group. A central and respiratory stimulant with a brief duration of action, it is used (generally as the hydrochloride or the hydrochloride hydrate) as a temporary treatment of acute respiratory failure, particularly when superimposed on chronic obstructive pulmonary disease, and of postoperative respiratory depression. It has also been used for treatment of postoperative shivering. |
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| has effect |
http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000589 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000492 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000493 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0001489 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000677 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0001538 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0001050 http://purl.obolibrary.org/obo/OAE_0000587 http://purl.obolibrary.org/obo/OAE_0000586 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000194 http://purl.obolibrary.org/obo/OAE_0001443 |
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| has pharmacological target | ||
| has role | ||
| InChI |
InChI=1S/C24H30N2O2/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21/h3-12,22H,2,13-19H2,1H3 |
|
| InChIKey |
InChIKey=XFDJYSQDBULQSI-UHFFFAOYSA-N |
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| inhibits | ||
| label |
doxapram |
|
| prefixIRI |
obo2:CHEBI_681848 |
|
| prefLabel |
doxapram |
|
| SMILES |
CCN1CC(CCN2CCOCC2)C(C1=O)(c1ccccc1)c1ccccc1 CCN1CC(CCN2CCOCC2)C(C1=O)(C1=CC=CC=C1)C1=CC=CC=C1 |
|
| Synonym |
(+-)-doxapram 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone C24H30N2O2 Doxapram 1-ethyl-4-[2-(morpholin-4-yl)ethyl]-3,3-diphenylpyrrolidin-2-one doxapram |
|
| xref |
National Drug Code Directory:55390-035-01 Patent:BE613734 DrugBank:DB00561 CiteXplore:4122029 CiteXplore:19663568 Beilstein:628691 Patent:US3192206 Wikipedia:http://en.wikipedia.org/wiki/Doxapram ChemSpider:3044 Wikipedia:Doxapram PubChem Compound:3156 CiteXplore:527638 Drugs Product Database (DPD):1914154 Drugs.com:http://www.drugs.com/cdi/doxapram.html KEGG DRUG:D07873 PubChem Substance:46506829 CiteXplore:20140700 RxList:http://www.rxlist.com/cgi/generic2/doxapram.htm ChEBI:681848 Reaxys:628691 PharmGKB:PA164784026 CASRN:309-29-5 CiteXplore:4126096 |
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| subClassOf |