The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	megestrol
Synonyms	C21H28O3 C22H30O3 megestrol megestrolum 17-hydroxypregna-4,6-diene-3,20-dione (1S,2R,10R,11S,14R,15S)-14-acetyl-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-6,8-dien-5-one Megestrol 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione
ID	http://purl.obolibrary.org/obo/CHEBI_6722
activates	http://purl.obolibrary.org/obo/dinto_2874 http://purl.obolibrary.org/obo/dinto_3882
AHFScode	10:00.00
ATCCode	L02AB01 G03AC05 G03DB02 G03DB04
binds	http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_3882 http://purl.obolibrary.org/obo/dinto_2874
CASRN	3562-63-8
DBBrand	niagestin magestin megeron ovarid ovaban megace
DBname	megestrol
DBSynonym	megestrolum [inn-latin] megestrolo [dcit] megestryl acetate mga megestrol acetate
Definition	A 17alpha-hydroxy steroid that has formula C22H30O3.
has effect	http://purl.obolibrary.org/obo/OAE_0000447 http://purl.obolibrary.org/obo/OAE_0000785 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000604 http://purl.obolibrary.org/obo/OAE_0001505 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001744 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0001186 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000317 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000762 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000050 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000861 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000386 http://purl.obolibrary.org/obo/OAE_0001340 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0000434 http://purl.obolibrary.org/obo/OAE_0001243 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000185 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001001 http://purl.obolibrary.org/obo/OAE_0000501 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0001035 http://purl.obolibrary.org/obo/OAE_0001497 http://purl.obolibrary.org/obo/OAE_0001044 http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target	http://purl.obolibrary.org/obo/dinto_3882
has role	http://purl.obolibrary.org/obo/CHEBI_50779 http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_59826 http://purl.obolibrary.org/obo/CHEBI_49323 http://purl.obolibrary.org/obo/CHEBI_49326
InChI	InChI=1S/C21H28O3/c1-13(22)21(24)11-8-18-16-5-4-14-12-15(23)6-9-19(14,2)17(16)7-10-20(18,21)3/h4-5,12,16-18,24H,6-11H2,1-3H3/t16-,17+,18+,19+,20+,21+/m1/s1
InChIKey	InChIKey=JBVNBBXAMBZTMQ-CEGNMAFCSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_1440
label	megestrol
may interact with	http://purl.obolibrary.org/obo/CHEBI_102524 http://purl.obolibrary.org/obo/dinto_DB00400 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/dinto_DB00794 http://purl.obolibrary.org/obo/dinto_DB00306 http://purl.obolibrary.org/obo/CHEBI_4888 http://purl.obolibrary.org/obo/dinto_DB01355 http://purl.obolibrary.org/obo/CHEBI_102216 http://purl.obolibrary.org/obo/dinto_DB00532 http://purl.obolibrary.org/obo/CHEBI_8069 http://purl.obolibrary.org/obo/dinto_DB00312 http://purl.obolibrary.org/obo/dinto_DB01354 http://purl.obolibrary.org/obo/dinto_DB00237 http://purl.obolibrary.org/obo/dinto_DB01352 http://purl.obolibrary.org/obo/CHEBI_6758 http://purl.obolibrary.org/obo/dinto_DB01351 http://purl.obolibrary.org/obo/dinto_DB01320 http://purl.obolibrary.org/obo/dinto_DB01353 http://purl.obolibrary.org/obo/CHEBI_9073
modulates	http://purl.obolibrary.org/obo/dinto_2874 http://purl.obolibrary.org/obo/dinto_3882
prefixIRI	obo2:CHEBI_6722
prefLabel	megestrol
SMILES	[H][C@]12CC[C@@]3(C)[C@@]([H])(CC[C@]3(O)C(C)=O)[C@]1([H])C=CC1=CC(=O)CC[C@]21C [H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C=CC2=CC(=O)CC[C@]12C
Synonym	C21H28O3 C22H30O3 megestrol megestrolum 17-hydroxypregna-4,6-diene-3,20-dione (1S,2R,10R,11S,14R,15S)-14-acetyl-14-hydroxy-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-6,8-dien-5-one Megestrol 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione
xref	CASRN:3562-63-8 Beilstein:3164843 ChEBI:6722 DrugBank:DB00351 KEGG COMPOUND:C07120 RxList:http://www.rxlist.com/cgi/generic4/megace_es.htm Drugs.com:http://www.drugs.com/cdi/megestrol.html PharmGKB:PA450351 National Drug Code Directory:0054-3542-58 Wikipedia:http://en.wikipedia.org/wiki/Megestrol Drugs Product Database (DPD):2223112 KEGG DRUG:D08167
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_6722	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6722	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6722	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6722	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6722	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6722	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6722	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6722	ODNAE	SAME_URI
http://purl.obolibrary.org/obo/XCO_0001177	XCO	LOOM
http://purl.bioontology.org/ontology/RCD/x01MD	RCD	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.745.432.531	RH-MESH	LOOM
http://purl.bioontology.org/ontology/MESH/D008535	MESH	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0025175	OCHV	LOOM
http://purl.jp/bio/4/id/200906078759082872	IOBC	LOOM
http://purl.bioontology.org/ontology/ATC/G03DB02	ATC	LOOM
http://purl.obolibrary.org/obo/MESH_D008535	BERO	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000020211	NDFRT	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018676	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/RXNORM/6703	RXNORM	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000020211	ODAE	LOOM
http://id.nlm.nih.gov/mesh/D008535	MDM	LOOM
http://purl.obolibrary.org/obo/OMIT_0009601	OMIT	LOOM
http://purl.obolibrary.org/obo/CHEBI_6722	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_6722	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6722	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6722	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_6722	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_6722	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_6722	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_6722	ODNAE	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#7885	OCHV	LOOM
http://stirdf.jst.go.jp/id/200907011805450861	IOBC	LOOM
http://purl.bioontology.org/ontology/VANDF/4022205	VANDF	LOOM
http://purl.bioontology.org/ontology/ATC/L02AB01	ATC	LOOM
http://purl.bioontology.org/ontology/NDDF/004823	NDDF	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008535	RH-MESH	LOOM
http://www.co-ode.org/ontologies/galen#Megestrol	GALEN	LOOM
http://purl.obolibrary.org/obo/NCIT_C630	BERO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/126091007	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/ATC/G03AC05	ATC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C630	NCIT	LOOM
http://purl.bioontology.org/ontology/SNMI/C-78140	SNMI	LOOM
http://www.drugbank.ca/drugs/DB00351	FTC	LOOM