The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Preferred Name	medroxyprogesterone
Synonyms	(6alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione Medroxyprogesteron medroxiprogesterona C22H32O3 6alpha-Methyl-4-pregnen-17alpha-ol-3,20-dione 6alpha-Methyl-17alpha-hydroxyprogesterone 17-Hydroxy-6alpha-methyl-pregn-4-ene-3,20-dione medroxyprogesterone medroxyprogesteronum 17alpha-Hydroxy-6alpha-methylprogesterone 17-Hydroxy-6alpha-methylprogesterone (1S,2R,8S,10R,11S,14R,15S)-14-acetyl-14-hydroxy-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
ID	http://purl.obolibrary.org/obo/CHEBI_6715
activates	http://purl.obolibrary.org/obo/dinto_3882 http://purl.obolibrary.org/obo/dinto_2827
AHFScode	68:32.00
ATCCode	G03AC06 L02AB02 G03DA02
binds	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0958 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_3882 http://purl.obolibrary.org/obo/dinto_2827
CASRN	520-85-4
DBBrand	aragest 5 lutopolar meprate nidaxin metigestrona med-pro depo-clinovir depo-promone lutoral lunelle provera g-farlutal ralovera sodelut g progestalfa veramix clinofem sirprogen mpa gyn 5 perlutex leo depo-prodasone indivina farlutin asconale novo-medrone repromap gestapuran oragest nadigest progevera proverone prodasone aragest depot-medroxyprogesterone acetate hysron clinovir depo-progestin perlutex colirest repromix hematrol
DBname	medroxyprogesterone
DBSynonym	medrossiprogesterone [dcit] hydroxymethylprogesterone medroxiprogesterona [inn-spanish] medroxyprogesteronum [inn-latin] cbp-1011 medroxyprogesteron medroxiprogesteronum medroprogesterone acetate medroxyprogesteron acetate
Definition	A 17alpha-hydroxy steroid that has formula C22H32O3.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0000303 http://purl.obolibrary.org/obo/OAE_0001505 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001437 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0001273 http://purl.obolibrary.org/obo/OAE_0001259 http://purl.obolibrary.org/obo/OAE_0000318 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000839 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000479 http://purl.obolibrary.org/obo/OAE_0000492 http://purl.obolibrary.org/obo/OAE_0000198 http://purl.obolibrary.org/obo/OAE_0001744 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0000443 http://purl.obolibrary.org/obo/OAE_0001186 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0001489 http://purl.obolibrary.org/obo/OAE_0001449 http://purl.obolibrary.org/obo/OAE_0001360 http://purl.obolibrary.org/obo/OAE_0000801 http://purl.obolibrary.org/obo/OAE_0001369 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000577 http://purl.obolibrary.org/obo/OAE_0000212 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0001421 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000249 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000482 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000250 http://purl.obolibrary.org/obo/OAE_0001165 http://purl.obolibrary.org/obo/OAE_0000677 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000426 http://purl.obolibrary.org/obo/OAE_0000476 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000539 http://purl.obolibrary.org/obo/OAE_0000861 http://purl.obolibrary.org/obo/OAE_0000518 http://purl.obolibrary.org/obo/OAE_0001055 http://purl.obolibrary.org/obo/OAE_0001063 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0001026 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0001357 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0001396 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0001340 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000517 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0000802 http://purl.obolibrary.org/obo/OAE_0001105 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0000767 http://purl.obolibrary.org/obo/OAE_0001101 http://purl.obolibrary.org/obo/OAE_0000084 http://purl.obolibrary.org/obo/OAE_0001057 http://purl.obolibrary.org/obo/OAE_0000911 http://purl.obolibrary.org/obo/OAE_0000327 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0001190 http://purl.obolibrary.org/obo/OAE_0001529 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000772 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001135 http://purl.obolibrary.org/obo/OAE_0000643 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0001106 http://purl.obolibrary.org/obo/OAE_0000184 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000341 http://purl.obolibrary.org/obo/OAE_0000440 http://purl.obolibrary.org/obo/OAE_0000894 http://purl.obolibrary.org/obo/OAE_0000243 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000469 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0001164 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0001276 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000898 http://purl.obolibrary.org/obo/OAE_0001209 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0001336 http://purl.obolibrary.org/obo/OAE_0000302 http://purl.obolibrary.org/obo/OAE_0000022 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000185 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0000336 http://purl.obolibrary.org/obo/OAE_0001052 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000347 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000873 http://purl.obolibrary.org/obo/OAE_0001169 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000242 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0001263 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0000260 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0001170 http://purl.obolibrary.org/obo/OAE_0001035 http://purl.obolibrary.org/obo/OAE_0000766 http://purl.obolibrary.org/obo/OAE_0000618 http://purl.obolibrary.org/obo/OAE_0000500 http://purl.obolibrary.org/obo/OAE_0000534 http://purl.obolibrary.org/obo/OAE_0000299 http://purl.obolibrary.org/obo/OAE_0000480 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000506
has pharmacological target	http://purl.obolibrary.org/obo/dinto_3882 http://purl.obolibrary.org/obo/dinto_2827
has role	http://purl.obolibrary.org/obo/CHEBI_59826 http://purl.obolibrary.org/obo/CHEBI_49323 http://purl.obolibrary.org/obo/CHEBI_49326
InChI	InChI=1S/C22H32O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h12-13,16-18,25H,5-11H2,1-4H3/t13-,16+,17-,18-,20+,21-,22-/m0/s1
InChIKey	InChIKey=FRQMUZJSZHZSGN-HBNHAYAOSA-N
induces	http://purl.obolibrary.org/obo/dinto_0901
inhibits	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0958
is metabolised by	http://purl.obolibrary.org/obo/dinto_0901
is substrate of	http://purl.obolibrary.org/obo/dinto_0901
label	medroxyprogesterone
may interact with	http://purl.obolibrary.org/obo/CHEBI_102524 http://purl.obolibrary.org/obo/dinto_DB00400 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/dinto_DB00794 http://purl.obolibrary.org/obo/CHEBI_102166 http://purl.obolibrary.org/obo/dinto_DB00306 http://purl.obolibrary.org/obo/CHEBI_4888 http://purl.obolibrary.org/obo/CHEBI_50859 http://purl.obolibrary.org/obo/dinto_DB01355 http://purl.obolibrary.org/obo/CHEBI_102216 http://purl.obolibrary.org/obo/dinto_DB00532 http://purl.obolibrary.org/obo/CHEBI_8069 http://purl.obolibrary.org/obo/dinto_DB00312 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/dinto_DB01354 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/CHEBI_59594 http://purl.obolibrary.org/obo/dinto_DB00237 http://purl.obolibrary.org/obo/dinto_DB01352 http://purl.obolibrary.org/obo/CHEBI_6758 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/dinto_DB01351 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/CHEBI_51450 http://purl.obolibrary.org/obo/dinto_DB01320 http://purl.obolibrary.org/obo/dinto_DB01353 http://purl.obolibrary.org/obo/CHEBI_195280 http://purl.obolibrary.org/obo/CHEBI_9073
modulates	http://purl.obolibrary.org/obo/dinto_3882 http://purl.obolibrary.org/obo/dinto_2827
prefixIRI	obo2:CHEBI_6715
prefLabel	medroxyprogesterone
SMILES	[H][C@@]12CC[C@](O)(C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)CC[C@]12C [H][C@@]12C[C@H](C)C3=CC(=O)CC[C@]3(C)[C@@]1([H])CC[C@@]1(C)[C@@]2([H])CC[C@]1(O)C(C)=O
Synonym	(6alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione Medroxyprogesteron medroxiprogesterona C22H32O3 6alpha-Methyl-4-pregnen-17alpha-ol-3,20-dione 6alpha-Methyl-17alpha-hydroxyprogesterone 17-Hydroxy-6alpha-methyl-pregn-4-ene-3,20-dione medroxyprogesterone medroxyprogesteronum 17alpha-Hydroxy-6alpha-methylprogesterone 17-Hydroxy-6alpha-methylprogesterone (1S,2R,8S,10R,11S,14R,15S)-14-acetyl-14-hydroxy-2,8,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-5-one
xref	DrugBank:DB00603 Drugs Product Database (DPD):2247583 PharmGKB:PA450344 ChEBI:6715 ChEMBL:428173 Patent:US3061616 Patent:GB866381 Guide To Pharmacology:2879 PubChem Substance:46508895 Drugs.com:http://www.drugs.com/medroxyprogesterone.html ChemSpider:10185 PubChem Compound:10631 Wikipedia:http://en.wikipedia.org/wiki/Medroxyprogesterone Patent:US3043832 KEGG DRUG:D08166 Patent:US3377364 IUPHAR:2879 CASRN:520-85-4 KEGG COMPOUND:C07119 National Drug Code Directory:0009-0064-06 Beilstein:2510965 RxList:http://www.rxlist.com/cgi/generic/medrox.htm
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_6715	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6715	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6715	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6715	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6715	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6715	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6715	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6715	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6715	DRON	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#7875	OCHV	LOOM
http://purl.obolibrary.org/obo/NCIT_C629	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6715	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6715	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6715	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_6715	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6715	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_6715	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_6715	NIFSTD	LOOM
http://purl.obolibrary.org/obo/OMIT_0009591	OMIT	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C629	NCIT	LOOM
http://purl.obolibrary.org/obo/MESH_D008525	BERO	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147899	NDFRT	LOOM
http://www.drugbank.ca/drugs/DB00603	FTC	LOOM
http://purl.bioontology.org/ontology/NDDF/004938	NDDF	LOOM
http://purl.bioontology.org/ontology/ATC/G03DA02	ATC	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018731	PMAPP-PMO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D04.808.745.745.654.829.614	RH-MESH	LOOM
http://purl.bioontology.org/ontology/RXNORM/6691	RXNORM	LOOM
http://purl.bioontology.org/ontology/CSP/2422-8564	CRISP	LOOM
http://purl.bioontology.org/ontology/MESH/D008525	MESH	LOOM
http://purl.bioontology.org/ontology/ATC/G03AC06	ATC	LOOM
http://purl.bioontology.org/ontology/VANDF/4019810	VANDF	LOOM
http://purl.bioontology.org/ontology/RCD/x02MG	RCD	LOOM
http://purl.jp/bio/4/id/200906004151067745	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D008525	RH-MESH	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/126113007	SNOMEDCT	LOOM
http://stirdf.jst.go.jp/id/200907003378763184	IOBC	LOOM
http://purl.bioontology.org/ontology/ATC/L02AB02	ATC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0025147	OCHV	LOOM