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The Drug-Drug Interactions Ontology
| Preferred Name | axitinib | |
| Synonyms |
N-methyl-2-({3-[(E)-2-(pyridin-2-yl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide Inlyta axitinibum axitinib C22H18N4OS AG-013736 N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_66910 |
|
| AHFScode |
10:00
|
|
| ATCCode |
L01XE17
|
|
| binds |
http://purl.obolibrary.org/obo/dinto_0920 http://purl.obolibrary.org/obo/dinto_0552 http://purl.obolibrary.org/obo/dinto_0912 http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0276 |
|
| CASRN |
319460-85-0
|
|
| DBBrand |
inlyta?
|
|
| DBSynonym |
ag-013736
|
|
| Definition |
An indazole substituted at position 3 by a 2-(pyridin-2-yl)vinyl group and at position 6 by a 2-(N-methylaminocarboxy)phenylsulfanyl group. Used for the treatment of advanced renal cell carcinoma after failure of a first line systemic treatment. Axitinib is an oral, potent, and selective inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3. Axitinib is marketed under the name Inlyta?, and if one previous systemic therapy for kidney cell cancer has failed, axitinib is indicated.
|
|
| has pharmacological target |
http://purl.obolibrary.org/obo/dinto_0920 |
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_35610 |
|
| InChI |
InChI=1S/C22H18N4OS/c1-23-22(27)18-7-2-3-8-21(18)28-16-10-11-17-19(25-26-20(17)14-16)12-9-15-6-4-5-13-24-15/h2-14H,1H3,(H,23,27)(H,25,26)/b12-9+
|
|
| InChIKey |
InChIKey=RITAVMQDGBJQJZ-FMIVXFBMSA-N
|
|
| inhibits |
http://purl.obolibrary.org/obo/dinto_0920 |
|
| is metabolised by |
http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0291 |
|
| is substrate of |
http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0276 |
|
| is transported by | ||
| label |
axitinib
|
|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/CHEBI_45863 http://purl.obolibrary.org/obo/dinto_DB01323 |
|
| prefixIRI |
obo2:CHEBI_66910
|
|
| prefLabel |
axitinib
|
|
| SMILES |
CNC(=O)c1ccccc1Sc1ccc2c(\\C=C\\c3ccccn3)n[nH]c2c1
|
|
| Synonym |
N-methyl-2-({3-[(E)-2-(pyridin-2-yl)vinyl]-1H-indazol-6-yl}sulfanyl)benzamide Inlyta axitinibum axitinib C22H18N4OS AG-013736 N-methyl-2-({3-[(E)-2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide
|
|
| xref |
RxList:http://www.rxlist.com/inlyta-drug.htm ChEMBL:816337 CiteXplore:22683928 CiteXplore:22706540 CiteXplore:22699078 CiteXplore:22248343 CiteXplore:20740300 CiteXplore:22644797 CiteXplore:22545314 National Drug Code Directory:0069-0145-01 Drugs.com:http://www.drugs.com/mtm/axitinib.html PharmGKB:PA164924493 CiteXplore:21670972 CiteXplore:22549112 CiteXplore:22504156 CiteXplore:22787405 CiteXplore:22168366 CiteXplore:21301929 CiteXplore:22170007 ChEBI:66910 Wikipedia:http://en.wikipedia.org/wiki/Axitinib KEGG DRUG:D03218 CASRN:319460-85-0 CiteXplore:22733795 Wikipedia:Axitinib Reaxys:11333336
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| subClassOf |
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