loading...| Preferred Name |
mirabegron |
|
| Synonyms |
Myrbetriq C21H24N4O2S 2-(2-amino-1,3-thiazol-4-yl)-N-[4-(2-{[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)phenyl]acetamide mirabegron |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_65349 |
|
| activates | ||
| AHFScode |
86:12 |
|
| ATCCode |
G04BD12 |
|
| binds |
http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_3582 http://purl.obolibrary.org/obo/dinto_0217 http://purl.obolibrary.org/obo/dinto_1843 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_3568 |
|
| CASRN |
223673-61-8 |
|
| DBBrand |
myrbetriq metmiga betanis |
|
| DBSynonym |
ym-178 |
|
| Definition |
Mirabegron is a beta-3 adrenergic receptor agonist for the management of overactive bladder. It is an alternative to antimuscarinic drugs for this indication. FDA approved on June 28, 2012. A carboxamide obtained by formal condensation of the carboxy group of 2-amino-1,3-thiazol-4-ylacetic acid with the anilino group of (1R)-2-{[2-(4-aminophenyl)ethyl]amino}-1-phenylethanol. Used for the treatment of overactive bladder syndrome. |
|
| has pharmacological target | ||
| has role | ||
| InChI |
InChI=1S/C21H24N4O2S/c22-21-25-18(14-28-21)12-20(27)24-17-8-6-15(7-9-17)10-11-23-13-19(26)16-4-2-1-3-5-16/h1-9,14,19,23,26H,10-13H2,(H2,22,25)(H,24,27)/t19-/m0/s1 |
|
| InChIKey |
InChIKey=PBAPPPCECJKMCM-IBGZPJMESA-N |
|
| inhibits | ||
| is metabolised by |
http://purl.obolibrary.org/obo/dinto_2993 |
|
| is substrate of |
http://purl.obolibrary.org/obo/dinto_3582 http://purl.obolibrary.org/obo/dinto_0217 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_3568 |
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| is transported by | ||
| label |
mirabegron |
|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_4551 http://purl.obolibrary.org/obo/CHEBI_9566 http://purl.obolibrary.org/obo/CHEBI_75984 http://purl.obolibrary.org/obo/CHEBI_8466 http://purl.obolibrary.org/obo/CHEBI_6904 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/dinto_DB01026 |
|
| modulates | ||
| prefixIRI |
obo2:CHEBI_65349 |
|
| prefLabel |
mirabegron |
|
| SMILES |
Nc1nc(CC(=O)Nc2ccc(CCNC[C@H](O)c3ccccc3)cc2)cs1 NC1=NC(CC(=O)NC2=CC=C(CCNC[C@H](O)C3=CC=CC=C3)C=C2)=CS1 |
|
| Synonym |
Myrbetriq C21H24N4O2S 2-(2-amino-1,3-thiazol-4-yl)-N-[4-(2-{[(2R)-2-hydroxy-2-phenylethyl]amino}ethyl)phenyl]acetamide mirabegron |
|
| xref |
CiteXplore:22411211 KEGG DRUG:D09535 CiteXplore:20878594 CiteXplore:22734513 National Drug Code Directory:0469-2602-30 CiteXplore:22269146 ChEMBL:1469608 CiteXplore:22317789 Wikipedia:http://en.wikipedia.org/wiki/Mirabegron CiteXplore:21142693 Patent:EP1559427 Drugs.com:http://www.drugs.com/cdi/mirabegron.html Patent:EP2119700 Reaxys:11023250 CiteXplore:22430195 CiteXplore:22734512 CiteXplore:22687876 CiteXplore:22509825 CiteXplore:21510978 ChEBI:65349 RxList:http://www.rxlist.com/myrbetriq-drug.htm CiteXplore:22821779 CASRN:223673-61-8 CiteXplore:22691895 CiteXplore:22384458 |
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| subClassOf |