loading...| Preferred Name |
ritanserin |
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| Synonyms |
ritanserine R 55,667 C27H25F2N3OS 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one ritanserin ritanserinum 6-(2-(4-(bis(p-fluorophenyl)methylene)-piperidino)ethyl)-7-methyl-5H-thiazolo-(3,2-a)pyrimidin-5-one ritanserina R-55667 |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_64195 |
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| Definition |
A thiazolopyrimidine that is 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and long-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT2 (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action. |
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| has role |
http://purl.obolibrary.org/obo/CHEBI_35474 http://purl.obolibrary.org/obo/CHEBI_48561 http://purl.obolibrary.org/obo/CHEBI_48279 |
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| InChI |
InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3 |
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| InChIKey |
InChIKey=JUQLTPCYUFPYKE-UHFFFAOYSA-N |
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| label |
ritanserin |
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| prefixIRI |
obo2:CHEBI_64195 |
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| prefLabel |
ritanserin |
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| SMILES |
Cc1nc2sccn2c(=O)c1CCN1CCC(CC1)=C(c1ccc(F)cc1)c1ccc(F)cc1 |
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| Synonym |
ritanserine R 55,667 C27H25F2N3OS 6-(2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl)-7-methyl-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one ritanserin ritanserinum 6-(2-(4-(bis(p-fluorophenyl)methylene)-piperidino)ethyl)-7-methyl-5H-thiazolo-(3,2-a)pyrimidin-5-one ritanserina R-55667 |
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| xref |
CiteXplore:8974378 CiteXplore:11897543 KEGG DRUG:D05738 CASRN:87051-43-2 Wikipedia:Ritanserin Reaxys:4913835 Patent:US4533665 CiteXplore:18801405 ChEMBL:110747 CiteXplore:12905101 |
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| subClassOf |