The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	leflunomide
Synonyms	Leflunomide Arava leflunomida leflunomide 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide leflunomidum C12H9F3N2O2 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide
ID	http://purl.obolibrary.org/obo/CHEBI_6402
activates	http://purl.obolibrary.org/obo/dinto_1446
AHFScode	92:00.00
ATCCode	L04AA13
binds	http://purl.obolibrary.org/obo/dinto_0637 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2310 http://purl.obolibrary.org/obo/dinto_1446 http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_0883
blocks	http://purl.obolibrary.org/obo/dinto_2310
CASRN	75706-12-6
DBBrand	arava
DBname	leflunomide
DBSynonym	leflunomidum [inn-latin] lefunomide [inn-spanish]
Definition	A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000496 http://purl.obolibrary.org/obo/OAE_0000447 http://purl.obolibrary.org/obo/OAE_0000424 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000905 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0001259 http://purl.obolibrary.org/obo/OAE_0000839 http://purl.obolibrary.org/obo/OAE_0000630 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000479 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000650 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0000825 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000493 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0000443 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000412 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0001095 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000250 http://purl.obolibrary.org/obo/OAE_0001025 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000454 http://purl.obolibrary.org/obo/OAE_0001026 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000691 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0001234 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0000419 http://purl.obolibrary.org/obo/OAE_0000434 http://purl.obolibrary.org/obo/OAE_0001243 http://purl.obolibrary.org/obo/OAE_0001190 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0001341 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001135 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000533 http://purl.obolibrary.org/obo/OAE_0000894 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000469 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000789 http://purl.obolibrary.org/obo/OAE_0001164 http://purl.obolibrary.org/obo/OAE_0000968 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0001202 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0001104 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0001403 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0001205 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0001147 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001030 http://purl.obolibrary.org/obo/OAE_0000565 http://purl.obolibrary.org/obo/OAE_0000514 http://purl.obolibrary.org/obo/OAE_0000501 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0001166 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0000618 http://purl.obolibrary.org/obo/OAE_0001458 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000811 http://purl.obolibrary.org/obo/OAE_0000350
has pharmacological target	http://purl.obolibrary.org/obo/dinto_0637
has role	http://purl.obolibrary.org/obo/CHEBI_35705 http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_38637 http://purl.obolibrary.org/obo/CHEBI_62670 http://purl.obolibrary.org/obo/CHEBI_68542 http://purl.obolibrary.org/obo/CHEBI_68543 http://purl.obolibrary.org/obo/CHEBI_50908 http://purl.obolibrary.org/obo/CHEBI_35475 http://purl.obolibrary.org/obo/CHEBI_35442 http://purl.obolibrary.org/obo/CHEBI_50266
InChI	InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
InChIKey	InChIKey=VHOGYURTWQBHIL-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_0637 http://purl.obolibrary.org/obo/dinto_2058
is metabolised by	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058
is substrate of	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0883
is transported by	http://purl.obolibrary.org/obo/dinto_0883
label	leflunomide
may interact with	http://purl.obolibrary.org/obo/dinto_DB00541 http://purl.obolibrary.org/obo/CHEBI_681569 http://purl.obolibrary.org/obo/dinto_DB00291 http://purl.obolibrary.org/obo/CHEBI_53766 http://purl.obolibrary.org/obo/CHEBI_133809 http://purl.obolibrary.org/obo/dinto_DB01285 http://purl.obolibrary.org/obo/dinto_DB00570 http://purl.obolibrary.org/obo/dinto_DB00290 http://purl.obolibrary.org/obo/CHEBI_59594 http://purl.obolibrary.org/obo/CHEBI_567361 http://purl.obolibrary.org/obo/CHEBI_3423 http://purl.obolibrary.org/obo/dinto_DB06372 http://purl.obolibrary.org/obo/CHEBI_480999 http://purl.obolibrary.org/obo/CHEBI_10033 http://purl.obolibrary.org/obo/CHEBI_68540 http://purl.obolibrary.org/obo/CHEBI_4513 http://purl.obolibrary.org/obo/CHEBI_27899 http://purl.obolibrary.org/obo/CHEBI_28077 http://purl.obolibrary.org/obo/CHEBI_31355 http://purl.obolibrary.org/obo/dinto_DB06210
modulates	http://purl.obolibrary.org/obo/dinto_2310 http://purl.obolibrary.org/obo/dinto_1446
prefixIRI	obo2:CHEBI_6402
prefLabel	leflunomide
SMILES	Cc1oncc1C(=O)Nc1ccc(cc1)C(F)(F)F CC1=C(C=NO1)C(=O)NC1=CC=C(C=C1)C(F)(F)F
Synonym	Leflunomide Arava leflunomida leflunomide 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide leflunomidum C12H9F3N2O2 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide
xref	CiteXplore:15934905 CiteXplore:15789891 CiteXplore:15665760 PubChem Substance:46506013 CiteXplore:11271257 CiteXplore:9625011 CiteXplore:16769661 DrugBank:DB01097 CiteXplore:8610393 CiteXplore:11043056 Patent:DE2854439 CiteXplore:11067959 PubChem Compound:3899 CiteXplore:11391470 CiteXplore:15489872 KEGG COMPOUND:C07905 CiteXplore:16202258 RxList:http://www.rxlist.com/cgi/generic3/leflunomide.htm CiteXplore:18034546 CiteXplore:11340750 CiteXplore:15214907 CiteXplore:12833393 Reaxys:4323174 CiteXplore:7496341 CiteXplore:9075844 CiteXplore:16284916 CiteXplore:12017890 CiteXplore:19169882 CiteXplore:14622739 Beilstein:4323174 Wikipedia:http://en.wikipedia.org/wiki/Leflunomide CiteXplore:15030575 CiteXplore:15127968 CiteXplore:18413415 CiteXplore:11475244 KEGG DRUG:D00749 CiteXplore:19715969 CiteXplore:11876141 CiteXplore:10890256 CiteXplore:15385935 CiteXplore:16688677 CiteXplore:15188371 CiteXplore:18496682 CiteXplore:11522581 CiteXplore:15652966 CiteXplore:17854740 CiteXplore:16638420 ChemSpider:3762 Drugs.com:http://www.drugs.com/cdi/leflunomide.html CiteXplore:11994686 CiteXplore:15127974 CiteXplore:19751817 CiteXplore:16638062 National Drug Code Directory:0555-0351-01 PharmGKB:PA450192 CiteXplore:18663553 CiteXplore:19190124 ChEBI:6402 CiteXplore:11053058 CiteXplore:17604599 CiteXplore:11333342 CiteXplore:17366662 CiteXplore:16645972 CiteXplore:18688040 ChEMBL:193895 CiteXplore:16142756 CiteXplore:10515382 CiteXplore:10702725 CASRN:75706-12-6 CiteXplore:11884931 CiteXplore:12074690 CiteXplore:18173611 CiteXplore:16106593 CiteXplore:15899055 CiteXplore:7676489 CiteXplore:19581389 HMDB:HMDB15229 CiteXplore:9777697 CiteXplore:16778342 CiteXplore:19770782 CiteXplore:11718154 CiteXplore:11707749 Wikipedia:Leflunomide CiteXplore:19344337 Drugs Product Database (DPD):2261278 CiteXplore:15537652 CiteXplore:17646975 Patent:US4284786 CiteXplore:9123314
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_6402	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6402	HOIP	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6402	COVID-19	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6402	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6402	TXPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6402	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6402	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6402	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_6402	ODNAE	SAME_URI
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1128	NCIT	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042253	PDQ	LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00471	COID	LOOM
http://www.co-ode.org/ontologies/galen#Leflunomide	GALEN	LOOM
http://purl.bioontology.org/ontology/VANDF/4021132	VANDF	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148586	NDFRT	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148586	ODAE	LOOM
http://purl.bioontology.org/ontology/LNC/LP34970-1	LOINC	LOOM
http://purl.bioontology.org/ontology/NDDF/007642	NDDF	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386981009	SNOMEDCT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#14180	OCHV	LOOM
http://purl.bioontology.org/ontology/MESH/D000077339	MESH	LOOM
http://stirdf.jst.go.jp/id/200907020767739835	IOBC	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026142	PMAPP-PMO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C045463	RH-MESH	LOOM
http://www.drugbank.ca/drugs/DB01097	FTC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0063041	OCHV	LOOM
https://go.drugbank.com/drugs/DB01097	MDM	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU017708	LOINC	LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02536	MIO	LOOM
http://purl.jp/bio/4/id/200906002440684105	IOBC	LOOM
http://bmi.utah.edu/ontologies/peontology/C0063041	RAO	LOOM
http://purl.obolibrary.org/obo/NCIT_C1128	BERO	LOOM
http://purl.bioontology.org/ontology/RXNORM/27169	RXNORM	LOOM
http://purl.bioontology.org/ontology/ATC/L04AK01	ATC	LOOM
http://purl.obolibrary.org/obo/CHEBI_6402	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_6402	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_6402	COVID-19	LOOM
http://purl.obolibrary.org/obo/CHEBI_6402	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6402	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_6402	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_6402	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_6402	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_6402	ODNAE	LOOM