loading...| Preferred Name |
iloprost |
|
| Synonyms |
iloprostum iloprost C22H32O4 (16R,S)-methyl-18,18,19,19-tetradehydro-6a-carbaprostaglandin I2 (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid 2-oxo-2-phenylethyl 5-[(2Z)-5-hydroxy-4-[(1E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]-octahydropentalen-2-ylidene]pentanoate C30H38O5 |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_63916 |
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| activates | ||
| ATCCode |
B01AC11 |
|
| CASRN |
78919-13-8 |
|
| DBBrand |
ventavis |
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| DBname |
iloprost |
|
| Definition |
A carbobicyclic compound that is prostaglandin I2 in which the endocyclic oxygen is replaced by a methylene group and in which the (1E,3S)-3-hydroxyoct-1-en-1-yl side chain is replaced by a (3R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl group. A synthetic analogue of prostacyclin, it is used as the trometamol salt (generally by intravenous infusion) for the treatment of peripheral vascular disease and pulmonary hypertension. |
|
| has effect |
http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001437 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0001013 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0000989 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0000362 |
|
| has pharmacological target | ||
| has role | ||
| InChI |
InChI=1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18+,19-,20+,21+/m0/s1 InChI=1S/C30H38O5/c1-3-4-10-21(2)27(31)16-15-25-26-18-22(17-24(26)19-28(25)32)11-8-9-14-30(34)35-20-29(33)23-12-6-5-7-13-23/h5-7,11-13,15-16,21,24-28,31-32H,8-10,14,17-20H2,1-2H3/b16-15+,22-11- |
|
| InChIKey |
InChIKey=HIFJCPQKFCZDDL-ACWOEMLNSA-N InChIKey=CZUMMMDKQYRZDP-JCAXBLPDSA-N |
|
| induces |
http://purl.obolibrary.org/obo/dinto_4063 http://purl.obolibrary.org/obo/dinto_3125 |
|
| is transported by |
http://purl.obolibrary.org/obo/dinto_1817 |
|
| label |
iloprost |
|
| prefixIRI |
obo2:CHEBI_63916 |
|
| prefLabel |
iloprost |
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| related with | ||
| SMILES |
[H][C@]1(\\C=C\\[C@@H](O)C(C)CC#CC)[C@H](O)C[C@@H]2C\\C(C[C@H]12)=C/CCCC(O)=O CC#CCC(C)C(O)\C=C\C1C(O)CC2C\C(CC12)=C\CCCC(=O)OCC(=O)C1=CC=CC=C1 |
|
| Synonym |
iloprostum iloprost C22H32O4 (16R,S)-methyl-18,18,19,19-tetradehydro-6a-carbaprostaglandin I2 (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid 2-oxo-2-phenylethyl 5-[(2Z)-5-hydroxy-4-[(1E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]-octahydropentalen-2-ylidene]pentanoate C30H38O5 |
|
| xref |
Patent:US4692464 ChEMBL:107494 KEGG DRUG:D02721 PharmGKB:PA164746843 Wikipedia:http://en.wikipedia.org/wiki/Iloprost National Drug Code Directory:66215-302-30 ChemSpider:4947911 Reaxys:4329060 PubChem Compound:6443959 DrugBank:DB01088 CiteXplore:14719835 RxList:http://www.rxlist.com/cgi/generic4/ventavis.htm CASRN:78919-13-8 PubChem Substance:46507818 Drugs.com:http://www.drugs.com/cdi/iloprost.html Patent:DE2845770 CiteXplore:15232651 CiteXplore:15241524 Wikipedia:Iloprost CiteXplore:19436672 |
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| subClassOf |