loading...| Preferred Name | propafenone | |
| Synonyms |
propafenona 1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one propafenone 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone C21H27NO3 propafenonum 2-(2'-hydroxy-3'-propylaminopropoxy)-omega-phenylpropiophenone |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_63619 |
|
| AHFScode |
24:04.04.12 |
|
| altId |
CHEBI:8465 |
|
| ATCCode |
C01BC03 |
|
| binds |
http://purl.obolibrary.org/obo/dinto_1670 http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_3187 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_1440 |
|
| CASRN |
54063-53-5 |
|
| DBBrand |
rythmol rythmol sr |
|
| DBname |
propafenone |
|
| DBSalt |
propafenone hydrochloride |
|
| DBSynonym |
propafenona [inn-spanish] propafenonum [inn-latin] |
|
| Definition |
A ketone that is 3-(propylamino)propane-1,2-diol in which the hydrogen of the primary hydroxy group is replaced by a 2-(3-phenylpropanoyl)phenyl group. It is a class 1C antiarrhythmic drug with local anesthetic effects, and is used as the hydrochloride salt in the management of supraventricular and ventricular arrhythmias. |
|
| has pharmacological target | ||
| has role | ||
| InChI |
InChI=1S/C21H27NO3/c1-2-14-22-15-18(23)16-25-21-11-7-6-10-19(21)20(24)13-12-17-8-4-3-5-9-17/h3-11,18,22-23H,2,12-16H2,1H3 |
|
| InChIKey |
InChIKey=JWHAUXFOSRPERK-UHFFFAOYSA-N |
|
| inhibits |
http://purl.obolibrary.org/obo/dinto_1670 http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_3187 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 |
|
| is metabolised by |
http://purl.obolibrary.org/obo/dinto_2651 |
|
| is substrate of |
http://purl.obolibrary.org/obo/dinto_2651 |
|
| label |
propafenone |
|
| prefixIRI |
obo2:CHEBI_63619 |
|
| prefLabel |
propafenone |
|
| SMILES |
CCCNCC(O)COC1=CC=CC=C1C(=O)CCC1=CC=CC=C1 CCCNCC(O)COc1ccccc1C(=O)CCc1ccccc1 |
|
| Synonym |
propafenona 1-{2-[2-hydroxy-3-(propylamino)propoxy]phenyl}-3-phenylpropan-1-one propafenone 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-1-propanone C21H27NO3 propafenonum 2-(2'-hydroxy-3'-propylaminopropoxy)-omega-phenylpropiophenone |
|
| xref |
Guide To Pharmacology:2561 PubChem Substance:46504529 Patent:DE2001431 PharmGKB:PA451131 Reaxys:2175182 Wikipedia:Propafenone PubChem Compound:4932 CiteXplore:8777484 KEGG COMPOUND:C07381 Drugs Product Database (DPD):2243728 National Drug Code Directory:0173-0786-01 DrugBank:DB01182 ChemSpider:4763 Drugs.com:http://www.drugs.com/cdi/propafenone.html Wikipedia:http://en.wikipedia.org/wiki/Propafenone RxList:http://www.rxlist.com/cgi/generic3/propafen.htm IUPHAR:2561 ChEMBL:127112 KEGG DRUG:D08435 CASRN:54063-53-5 BindingDB:50067133 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/ryt1392.shtml |
|
| subClassOf |