The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Jump to:
Preferred Name

nelarabine
Synonyms

Arranon

C11H15N5O5

2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine

(2R,3S,4S,5R)-2-(2-amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

nelzarabine

9-(beta-D-arabinofuranosyl)-6-methoxy-9H-purin-2-amine

Nelzarabine
ID

http://purl.obolibrary.org/obo/CHEBI_63612
ATCCode

L01BB07
binds

http://purl.obolibrary.org/obo/dinto_3867

http://purl.obolibrary.org/obo/dinto_2873

http://purl.obolibrary.org/obo/dinto_3662

http://purl.obolibrary.org/obo/dinto_0105

http://purl.obolibrary.org/obo/dinto_2044
CASRN

121032-29-9
DBBrand

atriance

arranon (glaxosmithkline)

arranon
DBname

nelarabine
DBSynonym

gw-506u78

nelzarabine
Definition

A purine nucleoside in which O-methylguanine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. Inhibits DNA synthesis and causes cell death; a prodrug of 9-beta-D-arabinofuranosylguanine (ara-G).
has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000391

http://purl.obolibrary.org/obo/OAE_0000839

http://purl.obolibrary.org/obo/OAE_0000406

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0001286

http://purl.obolibrary.org/obo/OAE_0000308

http://purl.obolibrary.org/obo/OAE_0000611

http://purl.obolibrary.org/obo/OAE_0000801

http://purl.obolibrary.org/obo/OAE_0001369

http://purl.obolibrary.org/obo/OAE_0000567

http://purl.obolibrary.org/obo/OAE_0000545

http://purl.obolibrary.org/obo/OAE_0000418

http://purl.obolibrary.org/obo/OAE_0001393

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0000317

http://purl.obolibrary.org/obo/OAE_0000482

http://purl.obolibrary.org/obo/OAE_0000333

http://purl.obolibrary.org/obo/OAE_0000382

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000310

http://purl.obolibrary.org/obo/OAE_0000426

http://purl.obolibrary.org/obo/OAE_0000883

http://purl.obolibrary.org/obo/OAE_0001288

http://purl.obolibrary.org/obo/OAE_0000608

http://purl.obolibrary.org/obo/OAE_0000539

http://purl.obolibrary.org/obo/OAE_0001055

http://purl.obolibrary.org/obo/OAE_0000646

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000375

http://purl.obolibrary.org/obo/OAE_0000551

http://purl.obolibrary.org/obo/OAE_0000455

http://purl.obolibrary.org/obo/OAE_0000943

http://purl.obolibrary.org/obo/OAE_0000084

http://purl.obolibrary.org/obo/OAE_0000995

http://purl.obolibrary.org/obo/OAE_0000671

http://purl.obolibrary.org/obo/OAE_0001014

http://purl.obolibrary.org/obo/OAE_0001308

http://purl.obolibrary.org/obo/OAE_0000494

http://purl.obolibrary.org/obo/OAE_0001129

http://purl.obolibrary.org/obo/OAE_0000842

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000542

http://purl.obolibrary.org/obo/OAE_0000243

http://purl.obolibrary.org/obo/OAE_0000864

http://purl.obolibrary.org/obo/OAE_0000414

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0001164

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0000508

http://purl.obolibrary.org/obo/OAE_0000898

http://purl.obolibrary.org/obo/OAE_0000647

http://purl.obolibrary.org/obo/OAE_0000306

http://purl.obolibrary.org/obo/OAE_0000302

http://purl.obolibrary.org/obo/OAE_0000022

http://purl.obolibrary.org/obo/OAE_0000385

http://purl.obolibrary.org/obo/OAE_0000491

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0001217

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0001128

http://purl.obolibrary.org/obo/OAE_0001291

http://purl.obolibrary.org/obo/OAE_0000514

http://purl.obolibrary.org/obo/OAE_0000374

http://purl.obolibrary.org/obo/OAE_0000686

http://purl.obolibrary.org/obo/OAE_0000402

http://purl.obolibrary.org/obo/OAE_0001298
has pharmacological target

http://purl.obolibrary.org/obo/dinto_2873
has role

http://purl.obolibrary.org/obo/CHEBI_35610

http://purl.obolibrary.org/obo/CHEBI_59517

http://purl.obolibrary.org/obo/CHEBI_50266
InChI

InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7+,10-/m1/s1
InChIKey

InChIKey=IXOXBSCIXZEQEQ-UHTZMRCNSA-N
inhibits

http://purl.obolibrary.org/obo/dinto_3867
is metabolised by

http://purl.obolibrary.org/obo/dinto_3662

http://purl.obolibrary.org/obo/dinto_0105

http://purl.obolibrary.org/obo/dinto_2044
is substrate of

http://purl.obolibrary.org/obo/dinto_3662

http://purl.obolibrary.org/obo/dinto_0105

http://purl.obolibrary.org/obo/dinto_2044
label

nelarabine
prefixIRI

obo2:CHEBI_63612
prefLabel

nelarabine
related with

http://purl.obolibrary.org/obo/dinto_2873
SMILES

COC1=NC(N)=NC2=C1N=CN2[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O

COc1nc(N)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O
Synonym

Arranon

C11H15N5O5

2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine

(2R,3S,4S,5R)-2-(2-amino-6-methoxy-9H-purin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

nelzarabine

9-(beta-D-arabinofuranosyl)-6-methoxy-9H-purin-2-amine

Nelzarabine
xref

CiteXplore:20043113

KEGG DRUG:D06488

CiteXplore:22184539

CiteXplore:21730354

CiteXplore:21190039

CiteXplore:21715318

Wikipedia:http://en.wikipedia.org/wiki/Nelarabine

PubChem Substance:46506325

CiteXplore:20796200

DrugBank:DB01280

ChemSpider:2280207

CiteXplore:18586926

National Drug Code Directory:0007-4401-06

CASRN:121032-29-9

RxList:http://www.rxlist.com/cgi/generic/arranon.htm

Drugs.com:http://www.drugs.com/cdi/nelarabine.html

KEGG DRUG:D05134

CiteXplore:20616909

PubChem Compound:3011155

CiteXplore:21737993

CiteXplore:19825456

Reaxys:13568768

ChEMBL:775063

CiteXplore:20528871

CiteXplore:21151585

CiteXplore:21353591

PharmGKB:PA164752425

CiteXplore:21320002
subClassOf

http://purl.obolibrary.org/obo/dinto_000055
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display
Create mapping

Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_63612 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63612 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63612 DDSS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63612 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_63612 DRON SAME_URI
http://www.drugbank.ca/drugs/DB01280 FTC LOOM
http://purl.bioontology.org/ontology/RXNORM/274771 RXNORM LOOM
http://purl.bioontology.org/ontology/MESH/C104457 MESH LOOM
https://go.drugbank.com/drugs/DB01280 MDM LOOM
http://purl.obolibrary.org/obo/NCIT_C1704 BERO LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000171753 NDFRT LOOM
http://purl.obolibrary.org/obo/CHEBI_63612 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_63612 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_63612 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_63612 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_63612 DRON LOOM
http://purl.bioontology.org/ontology/NDDF/011068 NDDF LOOM
http://purl.obolibrary.org/obo/DRON_00018842 ODNAE LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C104457 RH-MESH LOOM
http://purl.bioontology.org/ontology/ATC/L01BB07 ATC LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000043260 PDQ LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000043260 PDQ LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026290 PMAPP-PMO LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000171753 ODAE LOOM
http://purl.bioontology.org/ontology/VANDF/4025093 VANDF LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/418784008 SNOMEDCT LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1704 NCIT LOOM
http://stirdf.jst.go.jp/id/200907097885279540 IOBC LOOM
http://purl.jp/bio/4/id/200906008114320738 IOBC LOOM