| Synonyms |
maraviroc
4,4-difluoro-N-{(1R)-3-[(3-exo)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}cyclohexanecarboxamide
C29H41F2N5O
4,4-difluoro-N-[(1S)-3-[(1R,5S)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
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| Definition |
A carboxamide obtained by formal condensation of the carboxy group of 4,4-difluorocyclohexanecarboxylic acid and the amino group of (1R)-3-[(3-exo)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropylamine. Prevents the interaction of HIV-1 gp120 and chemokine receptor 5 (CCR5) necessary for CCR5-tropic HIV-1 to enter cells.
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| InChI |
InChI=1S/C29H41F2N5O/c1-19(2)27-34-33-20(3)36(27)25-17-23-9-10-24(18-25)35(23)16-13-26(21-7-5-4-6-8-21)32-28(37)22-11-14-29(30,31)15-12-22/h4-8,19,22-26H,9-18H2,1-3H3,(H,32,37)/t23-,24+,25?,26-/m0/s1 InChI=1S/C29H41F2N5O/c1-19(2)27-34-33-20(3)36(27)25-17-23-9-10-24(18-25)35(23)16-13-26(21-7-5-4-6-8-21)32-28(37)22-11-14-29(30,31)15-12-22/h4-8,19,22-26H,9-18H2,1-3H3,(H,32,37)/t23-,24+,25-,26-/m1/s1
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| Synonym |
maraviroc 4,4-difluoro-N-{(1R)-3-[(3-exo)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl}cyclohexanecarboxamide C29H41F2N5O 4,4-difluoro-N-[(1S)-3-[(1R,5S)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
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| xref |
DrugBank:DB04835 CiteXplore:22247337 CiteXplore:21393136 CiteXplore:22090117 CiteXplore:21134404 CiteXplore:22236118 Drugs.com:http://www.drugs.com/cdi/maraviroc.html CiteXplore:21505306 CASRN:376348-65-1 PubChem Substance:46508040 Wikipedia:http://en.wikipedia.org/wiki/Maraviroc Reaxys:10131963 CiteXplore:22118500 IUPHAR:806 CiteXplore:22017448 ChemSpider:2273675 RxList:http://www.rxlist.com/cgi/generic/selzentry.htm CiteXplore:22174038 PubChem Compound:3002977 KEGG DRUG:D06670 CiteXplore:21987241 CiteXplore:21595497 PharmGKB:PA164768835 National Drug Code Directory:0069-0807-60 CiteXplore:22034870 Guide To Pharmacology:806 CiteXplore:21383098 CiteXplore:22064539 CiteXplore:21692669 Wikipedia:Maraviroc
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