loading...| Preferred Name |
clocortolone |
|
| Synonyms |
C22H28ClFO4 9-chloro-6alpha-fluoro-16alpha-methyl-1,4-pregnadiene-11beta,21-diol-3,20-dione (1R,2S,8S,10S,11S,13R,14S,15S,17S)-1-chloro-8-fluoro-17-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one clocortolone 9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione clocortolonum clocortolona 9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methyl-1,4-pregnadien-3,20-dione |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_59582 |
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| activates | ||
| ATCCode |
D07AB21 |
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| CASRN |
34097-16-0 |
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| DBBrand |
cloderm |
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| DBname |
clocortolone |
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| DBSynonym |
clocortolone pivalate |
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| Definition |
16alpha-Methylpregna-1,4-diene-3,20-dione bearing hydroxy substituents at the 11beta and 21 positions, fluorine at position 6 and chlorine at position 9. A medium potency corticosteroid, it is used as its 21-O-pivalate or caproate ester for the relief of inflammatory and pruritic (itching) skin disorders. |
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| has effect |
http://purl.obolibrary.org/obo/OAE_0000489 |
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| has pharmacological target | ||
| has role | ||
| InChI |
InChI=1S/C22H28ClFO4/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-21(15,3)22(14,23)18(28)9-20(13,2)19(11)17(27)10-25/h4-5,7,11,13-14,16,18-19,25,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,18+,19-,20+,21+,22+/m1/s1 |
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| InChIKey |
InChIKey=YMTMADLUXIRMGX-RFPWEZLHSA-N |
|
| label |
clocortolone |
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| may interact with | ||
| prefixIRI |
obo2:CHEBI_59582 |
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| prefLabel |
clocortolone |
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| SMILES |
[H][C@@]12C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@H](O)[C@@]1(Cl)[C@@]2([H])C[C@H](F)C2=CC(=O)C=C[C@]12C |
|
| Synonym |
C22H28ClFO4 9-chloro-6alpha-fluoro-16alpha-methyl-1,4-pregnadiene-11beta,21-diol-3,20-dione (1R,2S,8S,10S,11S,13R,14S,15S,17S)-1-chloro-8-fluoro-17-hydroxy-14-(2-hydroxyacetyl)-2,13,15-trimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one clocortolone 9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione clocortolonum clocortolona 9-chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methyl-1,4-pregnadien-3,20-dione |
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| xref |
PharmGKB:PA164744013 KEGG DRUG:D07719 CASRN:4828-27-7 Beilstein:6318064 Wikipedia:Clocortolone ChEMBL:775317 Patent:DE2011559 Drugs.com:http://www.drugs.com/cdi/clocortolone.html RxList:http://www.rxlist.com/cgi/generic2/clocortolone.htm Patent:NL6412708 Patent:US3729495 Wikipedia:http://en.wikipedia.org/wiki/Clocortolone ChEBI:59582 DrugBank:DB00838 |
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| subClassOf |