The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Preferred Name	felodipine
Synonyms	felodipina felodipinum 3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate FELODIPINE (+-)-ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate felodipine ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate C18H19Cl2NO4 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
ID	http://purl.obolibrary.org/obo/CHEBI_585948
AHFScode	24:28.08
altId	CHEBI:4996 CHEBI:49383
ATCCode	C08CA02
binds	http://purl.obolibrary.org/obo/dinto_2962 http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_3113 http://purl.obolibrary.org/obo/dinto_2260 http://purl.obolibrary.org/obo/dinto_2979 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_0428 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_3508 http://purl.obolibrary.org/obo/dinto_1027 http://purl.obolibrary.org/obo/dinto_3240 http://purl.obolibrary.org/obo/dinto_0753 http://purl.obolibrary.org/obo/dinto_0432 http://purl.obolibrary.org/obo/dinto_1941 http://purl.obolibrary.org/obo/dinto_3324 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_1956
blocks	http://purl.obolibrary.org/obo/dinto_3324
CASRN	72509-76-3
DBBrand	perfudal felogard munobal agon preslow hydac penedil plendil retard splendil plandil felodur er lexxel plendil depottab feloday renedil modip agon sr plendil plendil er flodil prevex munobal retard
DBname	felodipine
DBSynonym	felodipine [usan:ban:inn] dl-felodipine felodipina [inn-spanish] felodipinum [inn-latin]
Definition	The mixed (methyl, ethyl) diester of 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylic acid. A calcium-channel blocker, it lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels. It is used in the management of hypertension and angina pectoris.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0001025 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000207 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001105 http://purl.obolibrary.org/obo/OAE_0001295 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0001126 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000565 http://purl.obolibrary.org/obo/OAE_0001001 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2962 http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_2979 http://purl.obolibrary.org/obo/dinto_3508 http://purl.obolibrary.org/obo/dinto_1027
has role	http://purl.obolibrary.org/obo/CHEBI_38070 http://purl.obolibrary.org/obo/CHEBI_35620 http://purl.obolibrary.org/obo/CHEBI_38215 http://purl.obolibrary.org/obo/CHEBI_35674
InChI	InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChIKey	InChIKey=RZTAMFZIAATZDJ-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_2962 http://purl.obolibrary.org/obo/dinto_2965 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_3113 http://purl.obolibrary.org/obo/dinto_2260 http://purl.obolibrary.org/obo/dinto_2979 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_0428 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_3508 http://purl.obolibrary.org/obo/dinto_1027 http://purl.obolibrary.org/obo/dinto_3240
is metabolised by	http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1956
is substrate of	http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1956
label	felodipine
may interact with	http://purl.obolibrary.org/obo/CHEBI_102524 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/dinto_DB00794 http://purl.obolibrary.org/obo/CHEBI_102166 http://purl.obolibrary.org/obo/dinto_DB00306 http://purl.obolibrary.org/obo/CHEBI_4888 http://purl.obolibrary.org/obo/dinto_DB01355 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/CHEBI_102216 http://purl.obolibrary.org/obo/dinto_DB00532 http://purl.obolibrary.org/obo/CHEBI_8069 http://purl.obolibrary.org/obo/dinto_DB00312 http://purl.obolibrary.org/obo/dinto_DB01354 http://purl.obolibrary.org/obo/dinto_DB01167 http://purl.obolibrary.org/obo/CHEBI_7824 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/dinto_DB00237 http://purl.obolibrary.org/obo/dinto_DB01352 http://purl.obolibrary.org/obo/CHEBI_15367 http://purl.obolibrary.org/obo/CHEBI_6758 http://purl.obolibrary.org/obo/CHEBI_3387 http://purl.obolibrary.org/obo/CHEBI_50861 http://purl.obolibrary.org/obo/CHEBI_63628 http://purl.obolibrary.org/obo/dinto_DB01351 http://purl.obolibrary.org/obo/dinto_DB00199 http://purl.obolibrary.org/obo/dinto_DB01369 http://purl.obolibrary.org/obo/CHEBI_31739 http://purl.obolibrary.org/obo/dinto_DB01320 http://purl.obolibrary.org/obo/dinto_DB01346 http://purl.obolibrary.org/obo/dinto_DB01353 http://purl.obolibrary.org/obo/dinto_DB00220 http://purl.obolibrary.org/obo/dinto_DB01341 http://purl.obolibrary.org/obo/CHEBI_9073 http://purl.obolibrary.org/obo/dinto_DB00976
modulates	http://purl.obolibrary.org/obo/dinto_3324
prefixIRI	obo2:CHEBI_585948
prefLabel	felodipine
related with	http://purl.obolibrary.org/obo/dinto_0753 http://purl.obolibrary.org/obo/dinto_0432 http://purl.obolibrary.org/obo/dinto_1941
SMILES	CCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(Cl)c1Cl)C(=O)OC CCOC(=O)C1=C(C)NC(C)=C(C1C1=C(Cl)C(Cl)=CC=C1)C(=O)OC
Synonym	felodipina felodipinum 3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate FELODIPINE (+-)-ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate 3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate felodipine ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate C18H19Cl2NO4 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
xref	Patent:US4264611 PDRhealth:http://www.pdrhealth.com/drugs/rx/rx-mono.aspx?contentFileNam NIST Chemistry WebBook:72509-76-3 National Drug Code Directory:0378-5011-01 Reaxys:4331472 Patent:EP7293 CASRN:72509-76-3 BindingDB:50017710 IUPHAR:4190 Wikipedia:http://en.wikipedia.org/wiki/Felodipine ChEMBL:18457386 ChEBI:585948 Wikipedia:Felodipine ChemSpider:3216 DrugBank:DB01023 PDBeChem:225 ChEMBL:505365 PubChem Substance:46506968 Drugs.com:http://www.drugs.com/cdi/felodipine.html Drugs Product Database (DPD):2222000 Guide To Pharmacology:4190 PharmGKB:PA449591 RxList:http://www.rxlist.com/cgi/generic2/felo.htm KEGG DRUG:D00319 PubChem Compound:3333
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_585948	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_585948	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_585948	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_585948	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_585948	CCONT	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_585948	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_585948	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_585948	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_585948	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_585948	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_585948	DRON	LOOM
http://purl.bioontology.org/ontology/ATC/C08CA02	ATC	LOOM
http://purl.obolibrary.org/obo/CHEBI_585948	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_585948	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_585948	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_585948	CCONT	LOOM
http://purl.obolibrary.org/obo/CHEBI_585948	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_585948	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_585948	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_585948	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_585948	EFO	LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#felodipine	SDO	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148116	OCVDAE	LOOM
http://purl.bioontology.org/ontology/NDDF/003602	NDDF	LOOM
http://stirdf.jst.go.jp/id/200907041125307092	IOBC	LOOM
https://go.drugbank.com/drugs/DB01023	MDM	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018331	PMAPP-PMO	LOOM
http://purl.obolibrary.org/obo/MESH_D015736	BERO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.725.203.250	RH-MESH	LOOM
http://www.drugbank.ca/drugs/DB01023	FTC	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29046	NCIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015736	RH-MESH	LOOM
http://purl.obolibrary.org/obo/NCIT_C29046	BERO	LOOM
http://www.co-ode.org/ontologies/galen#Felodipine	GALEN	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0015772	OCHV	LOOM
http://purl.bioontology.org/ontology/RCD/blc..	RCD	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#4945	OCHV	LOOM
http://purl.bioontology.org/ontology/RXNORM/4316	RXNORM	LOOM
http://purl.bioontology.org/ontology/MESH/D015736	MESH	LOOM
http://purl.bioontology.org/ontology/VANDF/4020159	VANDF	LOOM
http://purl.obolibrary.org/obo/OMIT_0016387	OMIT	LOOM
http://purl.jp/bio/4/id/200906048500995334	IOBC	LOOM
http://bmi.utah.edu/ontologies/hfontology/C0015772	HFO	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148116	NDFRT	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386863007	SNOMEDCT	LOOM