The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	donepezil
Synonyms	donepezilo 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one donepezil C24H29NO3 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one donepezilum
ID	http://purl.obolibrary.org/obo/CHEBI_53289
AHFScode	12:04.00
ATCCode	N06DA02
binds	http://purl.obolibrary.org/obo/dinto_1021 http://purl.obolibrary.org/obo/dinto_0392 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901
CASRN	120014-06-4
DBBrand	eranz aricept aricept odt
DBname	donepezil
Definition	Donepezil is a centrally acting reversible acetyl cholinesterase inhibitor. Its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
has effect	http://purl.obolibrary.org/obo/OAE_0000238 http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0001297 http://purl.obolibrary.org/obo/OAE_0000496 http://purl.obolibrary.org/obo/OAE_0000424 http://purl.obolibrary.org/obo/OAE_0000497 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000604 http://purl.obolibrary.org/obo/OAE_0001505 http://purl.obolibrary.org/obo/OAE_0000838 http://purl.obolibrary.org/obo/OAE_0000905 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001437 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000630 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000659 http://purl.obolibrary.org/obo/OAE_0000489 http://purl.obolibrary.org/obo/OAE_0000617 http://purl.obolibrary.org/obo/OAE_0000198 http://purl.obolibrary.org/obo/OAE_0000267 http://purl.obolibrary.org/obo/OAE_0000596 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0001186 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0001489 http://purl.obolibrary.org/obo/OAE_0000611 http://purl.obolibrary.org/obo/OAE_0001360 http://purl.obolibrary.org/obo/OAE_0000801 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000545 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000967 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0001436 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0001339 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000527 http://purl.obolibrary.org/obo/OAE_0000050 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000103 http://purl.obolibrary.org/obo/OAE_0000861 http://purl.obolibrary.org/obo/OAE_0000340 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000386 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000691 http://purl.obolibrary.org/obo/OAE_0000895 http://purl.obolibrary.org/obo/OAE_0001300 http://purl.obolibrary.org/obo/OAE_0000517 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0001234 http://purl.obolibrary.org/obo/OAE_0000802 http://purl.obolibrary.org/obo/OAE_0001105 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0000995 http://purl.obolibrary.org/obo/OAE_0001461 http://purl.obolibrary.org/obo/OAE_0000312 http://purl.obolibrary.org/obo/OAE_0001014 http://purl.obolibrary.org/obo/OAE_0001057 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0000526 http://purl.obolibrary.org/obo/OAE_0001070 http://purl.obolibrary.org/obo/OAE_0001284 http://purl.obolibrary.org/obo/OAE_0001068 http://purl.obolibrary.org/obo/OAE_0001529 http://purl.obolibrary.org/obo/OAE_0001374 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000586 http://purl.obolibrary.org/obo/OAE_0000772 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000433 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000674 http://purl.obolibrary.org/obo/OAE_0000894 http://purl.obolibrary.org/obo/OAE_0000473 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000469 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000789 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000968 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0001742 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0001104 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000898 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000185 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000336 http://purl.obolibrary.org/obo/OAE_0000421 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000514 http://purl.obolibrary.org/obo/OAE_0000873 http://purl.obolibrary.org/obo/OAE_0000501 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0001166 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0001309 http://purl.obolibrary.org/obo/OAE_0000716 http://purl.obolibrary.org/obo/OAE_0000618 http://purl.obolibrary.org/obo/OAE_0001749 http://purl.obolibrary.org/obo/OAE_0000534 http://purl.obolibrary.org/obo/OAE_0000885 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000350 http://purl.obolibrary.org/obo/OAE_0000304
has pharmacological target	http://purl.obolibrary.org/obo/dinto_1021
has role	http://purl.obolibrary.org/obo/CHEBI_66980 http://purl.obolibrary.org/obo/CHEBI_37733 http://purl.obolibrary.org/obo/CHEBI_38462
InChI	InChI=1S/C24H29NO3/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18/h3-7,14-15,17,20H,8-13,16H2,1-2H3
InChIKey	InChIKey=ADEBPBSSDYVVLD-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_1021
is metabolised by	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901
is substrate of	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901
label	donepezil
may interact with	http://purl.obolibrary.org/obo/CHEBI_8212 http://purl.obolibrary.org/obo/CHEBI_391960 http://purl.obolibrary.org/obo/CHEBI_7789 http://purl.obolibrary.org/obo/CHEBI_2946 http://purl.obolibrary.org/obo/CHEBI_16794 http://purl.obolibrary.org/obo/dinto_DB01621 http://purl.obolibrary.org/obo/CHEBI_4604 http://purl.obolibrary.org/obo/CHEBI_31981 http://purl.obolibrary.org/obo/dinto_DB00902 http://purl.obolibrary.org/obo/dinto_DB01142 http://purl.obolibrary.org/obo/CHEBI_6838 http://purl.obolibrary.org/obo/dinto_DB01625 http://purl.obolibrary.org/obo/CHEBI_8028 http://purl.obolibrary.org/obo/CHEBI_3651 http://purl.obolibrary.org/obo/CHEBI_4636 http://purl.obolibrary.org/obo/CHEBI_4639 http://purl.obolibrary.org/obo/CHEBI_5088 http://purl.obolibrary.org/obo/dinto_DB01619 http://purl.obolibrary.org/obo/CHEBI_3647 http://purl.obolibrary.org/obo/CHEBI_8707 http://purl.obolibrary.org/obo/dinto_DB00344 http://purl.obolibrary.org/obo/CHEBI_9711 http://purl.obolibrary.org/obo/dinto_DB00737 http://purl.obolibrary.org/obo/dinto_DB01246 http://purl.obolibrary.org/obo/dinto_DB00540 http://purl.obolibrary.org/obo/dinto_DB01591 http://purl.obolibrary.org/obo/dinto_DB00209 http://purl.obolibrary.org/obo/CHEBI_8871 http://purl.obolibrary.org/obo/CHEBI_45951 http://purl.obolibrary.org/obo/CHEBI_47499 http://purl.obolibrary.org/obo/dinto_DB00792 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/CHEBI_3743 http://purl.obolibrary.org/obo/CHEBI_3398 http://purl.obolibrary.org/obo/CHEBI_47780 http://purl.obolibrary.org/obo/CHEBI_3699 http://purl.obolibrary.org/obo/dinto_DB01437 http://purl.obolibrary.org/obo/CHEBI_59120 http://purl.obolibrary.org/obo/CHEBI_6780 http://purl.obolibrary.org/obo/CHEBI_9566 http://purl.obolibrary.org/obo/CHEBI_3183 http://purl.obolibrary.org/obo/CHEBI_7735 http://purl.obolibrary.org/obo/CHEBI_51380 http://purl.obolibrary.org/obo/CHEBI_51364 http://purl.obolibrary.org/obo/CHEBI_7856 http://purl.obolibrary.org/obo/CHEBI_3766 http://purl.obolibrary.org/obo/dinto_DB00780 http://purl.obolibrary.org/obo/CHEBI_8448 http://purl.obolibrary.org/obo/CHEBI_8459 http://purl.obolibrary.org/obo/dinto_DB00454 http://purl.obolibrary.org/obo/CHEBI_5121 http://purl.obolibrary.org/obo/CHEBI_9654 http://purl.obolibrary.org/obo/dinto_DB00427 http://purl.obolibrary.org/obo/dinto_DB00782 http://purl.obolibrary.org/obo/CHEBI_2618 http://purl.obolibrary.org/obo/CHEBI_10119 http://purl.obolibrary.org/obo/CHEBI_8461 http://purl.obolibrary.org/obo/CHEBI_8435 http://purl.obolibrary.org/obo/CHEBI_50841 http://purl.obolibrary.org/obo/CHEBI_3738 http://purl.obolibrary.org/obo/CHEBI_5818 http://purl.obolibrary.org/obo/CHEBI_9622 http://purl.obolibrary.org/obo/CHEBI_4046 http://purl.obolibrary.org/obo/CHEBI_27796 http://purl.obolibrary.org/obo/dinto_DB01247 http://purl.obolibrary.org/obo/CHEBI_53770 http://purl.obolibrary.org/obo/CHEBI_63629 http://purl.obolibrary.org/obo/dinto_DB00752 http://purl.obolibrary.org/obo/dinto_DB00376 http://purl.obolibrary.org/obo/dinto_DB01171 http://purl.obolibrary.org/obo/dinto_DB00462 http://purl.obolibrary.org/obo/CHEBI_28593 http://purl.obolibrary.org/obo/CHEBI_9123 http://purl.obolibrary.org/obo/CHEBI_6950 http://purl.obolibrary.org/obo/CHEBI_313639 http://purl.obolibrary.org/obo/CHEBI_3112 http://purl.obolibrary.org/obo/CHEBI_4514 http://purl.obolibrary.org/obo/CHEBI_16684 http://purl.obolibrary.org/obo/CHEBI_3994 http://purl.obolibrary.org/obo/CHEBI_3996 http://purl.obolibrary.org/obo/dinto_DB00986 http://purl.obolibrary.org/obo/CHEBI_4657 http://purl.obolibrary.org/obo/CHEBI_59788 http://purl.obolibrary.org/obo/CHEBI_8428 http://purl.obolibrary.org/obo/dinto_DB01114 http://purl.obolibrary.org/obo/CHEBI_44932 http://purl.obolibrary.org/obo/CHEBI_59269 http://purl.obolibrary.org/obo/CHEBI_3048 http://purl.obolibrary.org/obo/CHEBI_47781 http://purl.obolibrary.org/obo/dinto_DB01346 http://purl.obolibrary.org/obo/dinto_DB01618 http://purl.obolibrary.org/obo/dinto_DB00424 http://purl.obolibrary.org/obo/dinto_DB00934 http://purl.obolibrary.org/obo/CHEBI_518413 http://purl.obolibrary.org/obo/dinto_DB01623 http://purl.obolibrary.org/obo/CHEBI_2675 http://purl.obolibrary.org/obo/CHEBI_2666
prefixIRI	obo2:CHEBI_53289
prefLabel	donepezil
related with	http://purl.obolibrary.org/obo/dinto_0392
SMILES	[H]C1(CC2CCN(CC2)Cc2ccccc2)Cc2cc(OC)c(OC)cc2C1=O COC1=C(OC)C=C2C(=O)C(CC3CCN(CC4=CC=CC=C4)CC3)CC2=C1
Synonym	donepezilo 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one donepezil C24H29NO3 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one donepezilum
xref	KEGG DRUG:D07869 ChEBI:53289 PharmGKB:PA449394 Drugs Product Database (DPD):2232044 BindingDB:8960 Beilstein:7081955 Drugs.com:http://www.drugs.com/cdi/donepezil.html Wikipedia:Donepezil DrugBank:DB00843 DrugBank:120014-06-4 ChemSpider:3040 ChEMBL:109372 RxList:http://www.rxlist.com/cgi/generic/donepezil.htm PubChem Compound:3152 PubChem Substance:46504803 National Drug Code Directory:62856-851-30 CASRN:120014-06-4 Wikipedia:http://en.wikipedia.org/wiki/Donepezil Reaxys:7081955
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_53289	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_53289	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_53289	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_53289	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_53289	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_53289	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_53289	CIDO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_53289	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_53289	DRON	SAME_URI
http://mimi.case.edu/ontologies/2009/9/DrugOntology#donepezil	SDO	LOOM
https://go.drugbank.com/drugs/DB00843	MDM	LOOM
http://purl.jp/bio/4/id/200906032439129102	IOBC	LOOM
http://purl.obolibrary.org/obo/CHEBI_53289	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_53289	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_53289	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_53289	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_53289	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_53289	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_53289	CIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_53289	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_53289	DRON	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0527316	OCHV	LOOM
http://purl.bioontology.org/ontology/ATC/N06DA02	ATC	LOOM
http://doe-generated-ontology.com/OntoAD#C0527316	ONTOAD	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/386855006	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022050	NDFRT	LOOM
http://purl.bioontology.org/ontology/VANDF/4024045	VANDF	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026429	PMAPP-PMO	LOOM
http://stirdf.jst.go.jp/id/200907018966847758	IOBC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#38432	OCHV	LOOM
http://purl.bioontology.org/ontology/RXNORM/135447	RXNORM	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C076946	RH-MESH	LOOM
http://purl.obolibrary.org/obo/NCIT_C66874	BERO	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C66874	NCIT	LOOM
http://purl.bioontology.org/ontology/LNC/LP66954-6	LOINC	LOOM
http://www.drugbank.ca/drugs/DB00843	FTC	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU028051	LOINC	LOOM
https://bioportal.bioontology.org/ontologies/STMSO#Donepezil	STMSO	LOOM
http://purl.bioontology.org/ontology/MESH/D000077265	MESH	LOOM
http://stirdf.jst.go.jp/id/200907051280603833	IOBC	LOOM