The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Preferred Name	gatifloxacin
Synonyms	gatifloxacine gatifloxacinum 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid gatifloxacin C19H22FN3O4 1-cyclopropyl-6-fluoro- 8-methoxy-7-(3-methylpiperazin-1-yl)- 4-oxo-quinoline-3-carboxylic acid AM 1155 1-Cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid gatifloxacino
ID	http://purl.obolibrary.org/obo/CHEBI_5280
AHFScode	52:04.04
altId	CHEBI:101712
ATCCode	S01AE06 J01MA16
binds	http://purl.obolibrary.org/obo/dinto_1416 http://purl.obolibrary.org/obo/dinto_1417 http://purl.obolibrary.org/obo/dinto_1449 http://purl.obolibrary.org/obo/dinto_1448 http://purl.obolibrary.org/obo/dinto_0217
CASRN	112811-59-3
DBBrand	zymar tequin
DBname	gatifloxacin
Definition	A monocarboxylic acid that is 4-oxo-1,4-dihydroquinoline-3-carboxylic acid which is substituted on the nitrogen by a cyclopropyl group and at positions 6, 7, and 8 by fluoro, 3-methylpiperazin-1-yl, and methoxy groups, respectively. Gatifloxacin is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial topoisomerase type-II enzymes.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000838 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001510 http://purl.obolibrary.org/obo/OAE_0000902 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000630 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000479 http://purl.obolibrary.org/obo/OAE_0000596 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000825 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0001481 http://purl.obolibrary.org/obo/OAE_0000443 http://purl.obolibrary.org/obo/OAE_0001186 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0000611 http://purl.obolibrary.org/obo/OAE_0001360 http://purl.obolibrary.org/obo/OAE_0001333 http://purl.obolibrary.org/obo/OAE_0000549 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000412 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000805 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000984 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000937 http://purl.obolibrary.org/obo/OAE_0000770 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000386 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000517 http://purl.obolibrary.org/obo/OAE_0001003 http://purl.obolibrary.org/obo/OAE_0000312 http://purl.obolibrary.org/obo/OAE_0001057 http://purl.obolibrary.org/obo/OAE_0001243 http://purl.obolibrary.org/obo/OAE_0001190 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000586 http://purl.obolibrary.org/obo/OAE_0000510 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000533 http://purl.obolibrary.org/obo/OAE_0000542 http://purl.obolibrary.org/obo/OAE_0000894 http://purl.obolibrary.org/obo/OAE_0000473 http://purl.obolibrary.org/obo/OAE_0000837 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000968 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000329 http://purl.obolibrary.org/obo/OAE_0000508 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000405 http://purl.obolibrary.org/obo/OAE_0000536 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0001336 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000491 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0001147 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000470 http://purl.obolibrary.org/obo/OAE_0000501 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000716 http://purl.obolibrary.org/obo/OAE_0000766 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target	http://purl.obolibrary.org/obo/dinto_1416 http://purl.obolibrary.org/obo/dinto_1417 http://purl.obolibrary.org/obo/dinto_1449 http://purl.obolibrary.org/obo/dinto_1448
has role	http://purl.obolibrary.org/obo/CHEBI_22582 http://purl.obolibrary.org/obo/CHEBI_35441 http://purl.obolibrary.org/obo/CHEBI_50750
InChI	InChI=1S/C19H22FN3O4/c1-10-8-22(6-5-21-10)16-14(20)7-12-15(18(16)27-2)23(11-3-4-11)9-13(17(12)24)19(25)26/h7,9-11,21H,3-6,8H2,1-2H3,(H,25,26)
InChIKey	InChIKey=XUBOMFCQGDBHNK-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_1416 http://purl.obolibrary.org/obo/dinto_1417 http://purl.obolibrary.org/obo/dinto_1449 http://purl.obolibrary.org/obo/dinto_1448
label	gatifloxacin
may interact with	http://purl.obolibrary.org/obo/CHEBI_4551 http://purl.obolibrary.org/obo/CHEBI_6838 http://purl.obolibrary.org/obo/CHEBI_8028 http://purl.obolibrary.org/obo/CHEBI_3647 http://purl.obolibrary.org/obo/CHEBI_8491 http://purl.obolibrary.org/obo/CHEBI_9711 http://purl.obolibrary.org/obo/dinto_DB01397 http://purl.obolibrary.org/obo/CHEBI_45951 http://purl.obolibrary.org/obo/CHEBI_61049 http://purl.obolibrary.org/obo/dinto_DB00726 http://purl.obolibrary.org/obo/dinto_DB00893 http://purl.obolibrary.org/obo/CHEBI_63622 http://purl.obolibrary.org/obo/CHEBI_3172 http://purl.obolibrary.org/obo/CHEBI_6780 http://purl.obolibrary.org/obo/dinto_DB01370 http://purl.obolibrary.org/obo/CHEBI_9566 http://purl.obolibrary.org/obo/CHEBI_31794 http://purl.obolibrary.org/obo/dinto_DB00364 http://purl.obolibrary.org/obo/CHEBI_8459 http://purl.obolibrary.org/obo/CHEBI_5123 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/dinto_DB01593 http://purl.obolibrary.org/obo/CHEBI_10119 http://purl.obolibrary.org/obo/CHEBI_9635 http://purl.obolibrary.org/obo/CHEBI_8461 http://purl.obolibrary.org/obo/CHEBI_8435 http://purl.obolibrary.org/obo/dinto_DB01378 http://purl.obolibrary.org/obo/CHEBI_45716 http://purl.obolibrary.org/obo/CHEBI_28593 http://purl.obolibrary.org/obo/dinto_DB01118 http://purl.obolibrary.org/obo/dinto_DB01369 http://purl.obolibrary.org/obo/CHEBI_9544 http://purl.obolibrary.org/obo/CHEBI_3061 http://purl.obolibrary.org/obo/CHEBI_4657 http://purl.obolibrary.org/obo/dinto_DB01592 http://purl.obolibrary.org/obo/dinto_DB01346 http://purl.obolibrary.org/obo/dinto_DB01341 http://purl.obolibrary.org/obo/dinto_DB01623
prefixIRI	obo2:CHEBI_5280
prefLabel	gatifloxacin
related with	http://purl.obolibrary.org/obo/dinto_0217
SMILES	COC1=C2N(C=C(C(O)=O)C(=O)C2=CC(F)=C1N1CCNC(C)C1)C1CC1 COc1c(N2CCNC(C)C2)c(F)cc2c1n(cc(C(O)=O)c2=O)C1CC1
Synonym	gatifloxacine gatifloxacinum 1-cyclopropyl-6-fluoro-8-methoxy-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid gatifloxacin C19H22FN3O4 1-cyclopropyl-6-fluoro- 8-methoxy-7-(3-methylpiperazin-1-yl)- 4-oxo-quinoline-3-carboxylic acid AM 1155 1-Cyclopropyl-1,4-dihydro-6-fluoro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid gatifloxacino
xref	Reaxys:7445861 ChEMBL:7473575 Patent:EP230295 ChEMBL:12190308 ChEMBL:17960928 PubChem Substance:46506159 ChEMBL:15125930 National Drug Code Directory:0023-9218-05 ChEMBL:17043111 PubChem Compound:5379 ChEMBL:16078842 Drugs Product Database (DPD):2243181 ChEMBL:16554151 Gmelin:2281206 ChEMBL:17933535 ChEMBL:12620077 ChemSpider:5186 ChEMBL:17116666 Wikipedia:Gatifloxacin ChEMBL:12873512 Beilstein:7445861 CASRN:112811-59-3 KEGG COMPOUND:C07661 ChEMBL:15911273 ChEMBL:10737746 DrugBank:112811-59-3 ChEMBL:17325221 ChEMBL:12904069 PharmGKB:PA449738 KEGG DRUG:D08011 DrugBank:DB01044 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/zym1676.shtml Wikipedia:http://en.wikipedia.org/wiki/Gatifloxacin ChEMBL:17157008 ChEMBL:17804222 ChEMBL:17296740 ChEMBL:18078756 ChEMBL:17116668 ChEMBL:17043131 ChEMBL:15745831 Patent:US4980470 RxList:http://www.rxlist.com/cgi/generic3/gatifloxacin.htm ChEMBL:16759086 ChEMBL:17220425 ChEMBL:17276057 ChEBI:5280 ChEMBL:17261623 ChEMBL:17387152 ChEMBL:16337791 ChEMBL:17064062 Drugs.com:http://www.drugs.com/cdi/gatifloxacin-drops.html ChEMBL:18304818
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_5280	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5280	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5280	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5280	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5280	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5280	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5280	UPHENO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5280	PHIPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_5280	GENEPIO	SAME_URI
http://purl.obolibrary.org/obo/ARO_3000659	ARO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5280	DRON	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0753645	OCHV	LOOM
http://purl.obolibrary.org/obo/CHEBI_5280	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5280	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_5280	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5280	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_5280	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_5280	UPHENO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5280	PHIPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_5280	GENEPIO	LOOM
http://purl.bioontology.org/ontology/RXNORM/228476	RXNORM	LOOM
http://purl.bioontology.org/ontology/VANDF/4021187	VANDF	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026057	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/116349004	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/ATC/J01MA16	ATC	LOOM
http://purl.jp/bio/4/id/200906099719099702	IOBC	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU014634	LOINC	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148634	ODAE	LOOM
http://purl.obolibrary.org/obo/DRON_00016731	ODNAE	LOOM
http://stirdf.jst.go.jp/id/200907015984780068	IOBC	LOOM
http://purl.bioontology.org/ontology/NDDF/007995	NDDF	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C29070	NCIT	LOOM
http://purl.bioontology.org/ontology/MESH/D000077734	MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C078049	RH-MESH	LOOM
https://go.drugbank.com/drugs/DB01044	MDM	LOOM
http://purl.bioontology.org/ontology/LNC/LP28719-0	LOINC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#48581	OCHV	LOOM
http://purl.bioontology.org/ontology/ATC/S01AE06	ATC	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148634	NDFRT	LOOM
http://purl.obolibrary.org/obo/NCIT_C29070	BERO	LOOM