The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
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Preferred Name

fosinopril sodium
Synonyms

fosinopril sodium

C30H45NNaO7P

sodium (2S,4S)-4-cyclohexyl-1-({[2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)pyrrolidine-2-carboxylate
ID

http://purl.obolibrary.org/obo/CHEBI_5164
Definition

The sodium salt of fosinopril. It is used for the treatment of hypertension and heart failure. A pro-drug, its phosphinate ester group is hydrolysed in vivo to give the corresponding phosphininc acid, fosinoprilat, which is the active metabolite.
has role

http://purl.obolibrary.org/obo/CHEBI_35674

http://purl.obolibrary.org/obo/CHEBI_35457

http://purl.obolibrary.org/obo/CHEBI_50266
InChI

InChI=1S/C30H46NO7P.Na/c1-4-28(33)37-30(22(2)3)38-39(36,18-12-11-15-23-13-7-5-8-14-23)21-27(32)31-20-25(19-26(31)29(34)35)24-16-9-6-10-17-24;/h5,7-8,13-14,22,24-26,30H,4,6,9-12,15-21H2,1-3H3,(H,34,35);/q;+1/p-1/t25-,26+,30?,39?;/m1./s1
InChIKey

InChIKey=TVTJZMHAIQQZTL-HREVRLCXSA-M
label

fosinopril sodium
prefixIRI

obo2:CHEBI_5164
prefLabel

fosinopril sodium
SMILES

[Na+].[H][C@]1(C[C@H](N(C1)C(=O)CP(=O)(CCCCc1ccccc1)OC(OC(=O)CC)C(C)C)C([O-])=O)C1CCCCC1
Synonym

fosinopril sodium

C30H45NNaO7P

sodium (2S,4S)-4-cyclohexyl-1-({[2-methyl-1-(propanoyloxy)propoxy](4-phenylbutyl)phosphoryl}acetyl)pyrrolidine-2-carboxylate
xref

CASRN:88889-14-9

Patent:US2006160772

CiteXplore:9604795

Patent:WO02088149

CiteXplore:2967089

Beilstein:6840563

CiteXplore:18154978

KEGG DRUG:D00622
subClassOf

http://purl.obolibrary.org/obo/dinto_000055
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