The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Preferred Name	rosiglitazone
Synonyms	BRL-49653 rosiglitazona 5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione rosiglitazonum 5-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione rosiglitazone C18H19N3O3S 5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione
ID	http://purl.obolibrary.org/obo/CHEBI_50122
activates	http://purl.obolibrary.org/obo/dinto_2153
AHFScode	68:20.28
ATCCode	A10BG02
binds	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2026 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_2019 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0217 http://purl.obolibrary.org/obo/dinto_2153 http://purl.obolibrary.org/obo/dinto_0938
CASRN	122320-73-4
DBBrand	avandia rosiglizole
DBname	rosiglitazone
DBSalt	rosiglitazone maleate
Definition	A thiazolidenedione that has formula C18H19N3O3S.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001510 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000198 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0001026 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000084 http://purl.obolibrary.org/obo/OAE_0001057 http://purl.obolibrary.org/obo/OAE_0001200 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000344 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000336 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0001345 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0001298
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2153
has role	http://purl.obolibrary.org/obo/CHEBI_50864
InChI	InChI=1S/C18H19N3O3S/c1-21(16-4-2-3-9-19-16)10-11-24-14-7-5-13(6-8-14)12-15-17(22)20-18(23)25-15/h2-9,15H,10-12H2,1H3,(H,20,22,23)
InChIKey	InChIKey=YASAKCUCGLMORW-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2026 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_2019 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_1221
is metabolised by	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0938
is substrate of	http://purl.obolibrary.org/obo/dinto_0217 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0938
label	rosiglitazone
may interact with	http://purl.obolibrary.org/obo/CHEBI_5296 http://purl.obolibrary.org/obo/CHEBI_66876 http://purl.obolibrary.org/obo/CHEBI_59594 http://purl.obolibrary.org/obo/CHEBI_15367 http://purl.obolibrary.org/obo/dinto_DB00052 http://purl.obolibrary.org/obo/dinto_DB01026 http://purl.obolibrary.org/obo/CHEBI_28077
modulates	http://purl.obolibrary.org/obo/dinto_2153
prefixIRI	obo2:CHEBI_50122
prefLabel	rosiglitazone
SMILES	CN(CCOC1=CC=C(CC2SC(=O)NC2=O)C=C1)C1=CC=CC=N1 CN(CCOc1ccc(CC2SC(=O)NC2=O)cc1)c1ccccn1
Synonym	BRL-49653 rosiglitazona 5-((4-(2-(methyl-2-pyridinylamino)ethoxy)phenyl)methyl)-2,4-thiazolidinedione rosiglitazonum 5-(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}benzyl)-1,3-thiazolidine-2,4-dione rosiglitazone C18H19N3O3S 5-[(4-{2-[methyl(pyridin-2-yl)amino]ethoxy}phenyl)methyl]-1,3-thiazolidine-2,4-dione
xref	National Drug Code Directory:0029-3158-18 Wikipedia:Rosiglitazone Wikipedia:http://en.wikipedia.org/wiki/Rosiglitazone Drugs Product Database (DPD):2241113 PubChem Compound:77999 CASRN:122320-73-4 ChEMBL:120027 IUPHAR:1056 ChEBI:50122 BindingDB:28681 Guide To Pharmacology:1056 PDB:BRL PubChem Substance:46504556 Patent:EP306228 Patent:US5002953 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/cx1532.shtml RxList:http://www.rxlist.com/cgi/generic2/rosigl.htm Beilstein:7082202 DrugBank:DB00412 PharmGKB:PA451283 Drugs.com:http://www.drugs.com/cdi/rosiglitazone.html ChemSpider:70383
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_50122	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_50122	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_50122	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_50122	CCONT	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_50122	HOIP	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_50122	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_50122	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_50122	TXPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_50122	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_50122	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_50122	HINO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_50122	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_50122	CHEBI	LOOM
http://purl.obolibrary.org/obo/XCO_0000602	XCO	LOOM
http://purl.obolibrary.org/obo/CHEBI_50123	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_50125	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_50122	DRON	LOOM
http://purl.bioontology.org/ontology/VANDF/4021162	VANDF	LOOM
http://www.drugbank.ca/drugs/DB00412	FTC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#27757	OCHV	LOOM
http://purl.bioontology.org/ontology/MESH/D000077154	MESH	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148613	NDFRT	LOOM
http://purl.obolibrary.org/obo/CHEBI_50123	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_50123	BIOMODELS	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62076	NCIT	LOOM
http://stirdf.jst.go.jp/id/200907084297685979	IOBC	LOOM
http://purl.bioontology.org/ontology/NDDF/007789	NDDF	LOOM
http://purl.bioontology.org/ontology/ATC/A10BG02	ATC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0289313	OCHV	LOOM
http://purl.bioontology.org/ontology/CSP/5002-0036	CRISP	LOOM
http://purl.obolibrary.org/obo/NCIT_C62076	BERO	LOOM
http://www.semanticweb.org/khaled/ontologies/2024/7/CDMOnto#Rosiglitazone	CDMONTO	LOOM
http://mimi.case.edu/ontologies/2009/9/DrugOntology#rosiglitazone	SDO	LOOM
http://bmi.utah.edu/ontologies/hfontology/C0289313	HFO	LOOM
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571353432175145041	ACVD_ONTOLOGY	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C089730	RH-MESH	LOOM
https://go.drugbank.com/drugs/DB00412	MDM	LOOM
http://www.semanticweb.org/ontologies/STO.owl#efc1b_7e42_4b28_8656_ad90e5e873ea	STO-DRAFT	LOOM
http://www.semanticweb.org/ontologies/STO.owl#efc1b_7e42_4b28_8656_ad90e5e873ea	CVAO	LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:02131	MIO	LOOM
http://purl.jp/bio/4/id/200906027899434880	IOBC	LOOM
http://purl.obolibrary.org/obo/CHEBI_50122	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_50122	CCONT	LOOM
http://purl.obolibrary.org/obo/CHEBI_50122	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_50122	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_50122	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_50122	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_50122	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_50122	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_50122	HINO	LOOM
http://purl.obolibrary.org/obo/CHEBI_50122	EFO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/395869000	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/LNC/LP171637-4	LOINC	LOOM
http://purl.bioontology.org/ontology/RXNORM/84108	RXNORM	LOOM
http://purl.obolibrary.org/obo/CHEBI_50125	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_50125	BIOMODELS	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU068402	LOINC	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00025156	PMAPP-PMO	LOOM