CHEBI:38943

CHEBI:49372

L01XE06

302962-49-8

sprycel

dasatinib

bms-354825

An aminopyrimidine that is 2-methylpyrimidine which is substituted at position 4 by the primary amino group of 2-amino-1,3-thiazole-5-carboxylic acid and at position 6 by a 4-(2-hydroxyethyl)piperazin-1-yl group, and in which the carboxylic acid group has been formally condensed with 2-chloro-6-methylaniline to afford the corresponding amide. A multi-targeted kinase inhibitor, it is used, particularly as the monohydrate, for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN).

InChI=1S/C22H26ClN7O2S/c1-14-4-3-5-16(23)20(14)28-21(32)17-13-24-22(33-17)27-18-12-19(26-15(2)25-18)30-8-6-29(7-9-30)10-11-31/h3-5,12-13,31H,6-11H2,1-2H3,(H,28,32)(H,24,25,26,27)

InChIKey=ZBNZXTGUTAYRHI-UHFFFAOYSA-N

dasatinib (anhydrous)

obo2:CHEBI_49375

dasatinib (anhydrous)

CC1=NC(NC2=NC=C(S2)C(=O)NC2=C(C)C=CC=C2Cl)=CC(=N1)N1CCN(CCO)CC1

Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1

dasatinib (anh.)

C22H26ClN7O2S

N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide

anh. dasatinib

anhydrous dasatinib

dasatinibum

BMS Dasatinib

BMS-354825

N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE

dasatinib

CiteXplore:22411867

Reaxys:9966762

CiteXplore:18823558

CiteXplore:22992064

Wikipedia:http://en.wikipedia.org/wiki/Dasatinib

CiteXplore:23065516

CiteXplore:19494352

ChEMBL:461469

PubChem Compound:3062316

RxList:http://www.rxlist.com/cgi/generic/sprycel.htm

CiteXplore:19640584

HMDB:HMDB15384

BindingDB:13216

Patent:US7941725

Patent:US7125875

Drugs.com:http://www.drugs.com/cdi/dasatinib.html

PubChem Substance:46505143

CASRN:302962-49-8

ChemSpider:2323020

CiteXplore:17154512

PDBeChem:1N1

ChEBI:49375

CiteXplore:22740998

National Drug Code Directory:0003-0527-11

PharmGKB:PA162372878

CiteXplore:18784745

CiteXplore:18797457

KEGG DRUG:D03658

CiteXplore:19502192

Wikipedia:Dasatinib

CiteXplore:18020922

Patent:WO2010139979

CiteXplore:16775234

DrugBank:DB01254

CiteXplore:21226671

Patent:WO2010067374