The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	zoledronic acid
Synonyms	ZOL Reclast C5H10N2O7P2 (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) zoledronic acid (1-hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid [1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl]phosphonic acid ZOLEDRONIC ACID
ID	http://purl.obolibrary.org/obo/CHEBI_46557
AHFScode	92:00.00
ATCCode	M05BA08
blocks	http://purl.obolibrary.org/obo/dinto_2201
CASRN	118072-93-8
DBBrand	reclast zometa concentrate aclasta zometa
DBname	zoledronate
DBSynonym	zol zoledronic acid
Definition	An imidazole compound having a 2,2-bis(phosphono)-2-hydroxyethane-1-yl substituent at the 1-position.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000879 http://purl.obolibrary.org/obo/OAE_0001059 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0000597 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001259 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000659 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0000411 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0001260 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000545 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0000412 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000317 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0001365 http://purl.obolibrary.org/obo/OAE_0000608 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0001283 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001062 http://purl.obolibrary.org/obo/OAE_0001275 http://purl.obolibrary.org/obo/OAE_0000517 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0000084 http://purl.obolibrary.org/obo/OAE_0001190 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000772 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000643 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000533 http://purl.obolibrary.org/obo/OAE_0000243 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000789 http://purl.obolibrary.org/obo/OAE_0001164 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000606 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0001256 http://purl.obolibrary.org/obo/OAE_0000022 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000336 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000296 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000358 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0001298
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2201 http://purl.obolibrary.org/obo/dinto_0400 http://purl.obolibrary.org/obo/dinto_2846
has role	http://purl.obolibrary.org/obo/CHEBI_50646
InChI	InChI=1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
InChIKey	InChIKey=XRASPMIURGNCCH-UHFFFAOYSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_0400 http://purl.obolibrary.org/obo/dinto_2846
is transported by	http://purl.obolibrary.org/obo/dinto_2828
label	zoledronic acid
prefixIRI	obo2:CHEBI_46557
prefLabel	zoledronic acid
SMILES	OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O OC(CN1C=CN=C1)(P(O)(O)=O)P(O)(O)=O
Synonym	ZOL Reclast C5H10N2O7P2 (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) zoledronic acid (1-hydroxy-2-imidazol-1-ylethylidene)diphosphonic acid [1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl]phosphonic acid ZOLEDRONIC ACID
xref	PubChem Substance:46507310 Drugs Product Database (DPD):2242725 Gmelin:2609374 ChEMBL:183838 Patent:US4939130 BindingDB:12578 Beilstein:9205049 Wikipedia:http://en.wikipedia.org/wiki/Zoledronate PDB:ZOL DrugBank:118072-93-8 KEGG DRUG:D08689 PDBeChem:ZOL National Drug Code Directory:0078-0387-25 PharmGKB:PA10235 RxList:http://www.rxlist.com/cgi/generic/zometa.htm DrugBank:DB00399 CASRN:118072-93-8 Wikipedia:Zoledronic_Acid PubChem Compound:68740 ChemSpider:61986
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_46557	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_46557	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_46557	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_46557	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_46557	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_46557	CHEBI	LOOM
http://purl.obolibrary.org/obo/NCIT_C1699	BERO	LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00977	COID	LOOM
http://purl.obolibrary.org/obo/CHEBI_46557	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_46557	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_46557	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_46557	DRON	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148713	NDFRT	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026314	PMAPP-PMO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#25214	OCHV	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0257685	OCHV	LOOM
http://purl.bioontology.org/ontology/RXNORM/77655	RXNORM	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C088658	RH-MESH	LOOM
http://purl.bioontology.org/ontology/ATC/M05BA08	ATC	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000042507	PDQ	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C1699	NCIT	LOOM
http://purl.bioontology.org/ontology/VANDF/4021276	VANDF	LOOM
http://purl.bioontology.org/ontology/MESH/D000077211	MESH	LOOM
https://go.drugbank.com/drugs/DB00399	MDM	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/395926009	SNOMEDCT	LOOM