The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Preferred Name	diazoxide
Synonyms	diazoxidum 7-chloro-3-methyl-4H-1$l^{6},2,4-benzothiadiazine-1,1-dione Diazossido Diazoxide diazoxide 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide diazoxido C8H7ClN2O2S Eudemine
ID	http://purl.obolibrary.org/obo/CHEBI_4495
AHFScode	24:08.20
altId	CHEBI:6046
ATCCode	V03AH01 C02DA01
binds	http://purl.obolibrary.org/obo/dinto_3682 http://purl.obolibrary.org/obo/dinto_1621 http://purl.obolibrary.org/obo/dinto_2115 http://purl.obolibrary.org/obo/dinto_2664 http://purl.obolibrary.org/obo/dinto_0757 http://purl.obolibrary.org/obo/dinto_3879 http://purl.obolibrary.org/obo/dinto_3464
CASRN	364-98-7
DBBrand	hypertonalum mutabase proglycem proglicem eudemine hyperstat dizoxide
DBname	diazoxide
Definition	A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000879 http://purl.obolibrary.org/obo/OAE_0000081 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001437 http://purl.obolibrary.org/obo/OAE_0001273 http://purl.obolibrary.org/obo/OAE_0000391 http://purl.obolibrary.org/obo/OAE_0000218 http://purl.obolibrary.org/obo/OAE_0000198 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000807 http://purl.obolibrary.org/obo/OAE_0000308 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000539 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0000802 http://purl.obolibrary.org/obo/OAE_0001078 http://purl.obolibrary.org/obo/OAE_0001200 http://purl.obolibrary.org/obo/OAE_0001068 http://purl.obolibrary.org/obo/OAE_0000086 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000789 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0001276 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000780 http://purl.obolibrary.org/obo/OAE_0001209 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000194 http://purl.obolibrary.org/obo/OAE_0000491 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0001147 http://purl.obolibrary.org/obo/OAE_0000779 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000242 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000304
has pharmacological target	http://purl.obolibrary.org/obo/dinto_1621 http://purl.obolibrary.org/obo/dinto_2115 http://purl.obolibrary.org/obo/dinto_3464
has role	http://purl.obolibrary.org/obo/CHEBI_35498 http://purl.obolibrary.org/obo/CHEBI_35524 http://purl.obolibrary.org/obo/CHEBI_35620 http://purl.obolibrary.org/obo/CHEBI_35522 http://purl.obolibrary.org/obo/CHEBI_64338 http://purl.obolibrary.org/obo/CHEBI_38633 http://purl.obolibrary.org/obo/CHEBI_35674 http://purl.obolibrary.org/obo/CHEBI_38147 http://purl.obolibrary.org/obo/CHEBI_35523
InChI	InChI=1S/C8H7ClN2O2S/c1-5-10-7-3-2-6(9)4-8(7)14(12,13)11-5/h2-4H,1H3,(H,10,11)
InChIKey	InChIKey=GDLBFKVLRPITMI-UHFFFAOYSA-N
induces	http://purl.obolibrary.org/obo/dinto_3464
inhibits	http://purl.obolibrary.org/obo/dinto_3682 http://purl.obolibrary.org/obo/dinto_1621 http://purl.obolibrary.org/obo/dinto_2115
label	diazoxide
may interact with	http://purl.obolibrary.org/obo/dinto_DB00519 http://purl.obolibrary.org/obo/CHEBI_8107 http://purl.obolibrary.org/obo/CHEBI_3650 http://purl.obolibrary.org/obo/CHEBI_5441 http://purl.obolibrary.org/obo/CHEBI_5893 http://purl.obolibrary.org/obo/dinto_DB00310 http://purl.obolibrary.org/obo/CHEBI_3013 http://purl.obolibrary.org/obo/dinto_DB00999 http://purl.obolibrary.org/obo/dinto_DB01320
prefixIRI	obo2:CHEBI_4495
prefLabel	diazoxide
related with	http://purl.obolibrary.org/obo/dinto_2664 http://purl.obolibrary.org/obo/dinto_0757 http://purl.obolibrary.org/obo/dinto_3879
SMILES	CC1=NS(=O)(=O)C2=C(N1)C=CC(Cl)=C2 CC1=Nc2ccc(Cl)cc2S(=O)(=O)N1
Synonym	diazoxidum 7-chloro-3-methyl-4H-1$l^{6},2,4-benzothiadiazine-1,1-dione Diazossido Diazoxide diazoxide 7-chloro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide diazoxido C8H7ClN2O2S Eudemine
xref	Wikipedia:http://en.wikipedia.org/wiki/Diazoxide CiteXplore:15319354 PubChem Compound:3019 CiteXplore:20828743 CiteXplore:20950601 ChEBI:4495 PubChem Substance:46508027 Beilstein:523907 CiteXplore:16777075 CiteXplore:16740260 ChemSpider:2911 CiteXplore:18191077 CiteXplore:21693179 National Drug Code Directory:0575-6000-01 Drugs Product Database (DPD):503347 Guide To Pharmacology:2409 Patent:DE723278 CASRN:364-98-7 ChEMBL:464859 DrugBank:DB01119 CiteXplore:22047130 CiteXplore:21538163 Reaxys:523907 KEGG COMPOUND:C06949 KEGG DRUG:D00294 Patent:US2986573 CiteXplore:12039709 Drugs.com:http://www.drugs.com/cdi/diazoxide-suspension.html Patent:US3345365 IUPHAR:2409 PharmGKB:PA449285 Wikipedia:Diazoxide CiteXplore:11014217
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_4495	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4495	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4495	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4495	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4495	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4495	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4495	NIFSTD	SAME_URI
http://purl.bioontology.org/ontology/CSP/2898-5297	CRISP	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039290	PDQ	LOOM
http://purl.obolibrary.org/obo/CHEBI_4495	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_4495	DRON	LOOM
http://purl.obolibrary.org/obo/XCO_0000669	XCO	LOOM
https://go.drugbank.com/drugs/DB01119	MDM	LOOM
http://purl.obolibrary.org/obo/MESH_D003981	BERO	LOOM
http://www.drugbank.ca/drugs/DB01119	FTC	LOOM
http://purl.bioontology.org/ontology/VANDF/4018795	VANDF	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C428	NCIT	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387328001	SNOMEDCT	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017428	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/CSP/2898-5297	CRISP	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.655.500.300	RH-MESH	LOOM
http://purl.bioontology.org/ontology/NDDF/000636	NDDF	LOOM
http://purl.jp/bio/4/id/200906006023130143	IOBC	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.438.174.300	RH-MESH	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.590.700.135.300	RH-MESH	LOOM
http://purl.bioontology.org/ontology/RXNORM/3327	RXNORM	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000039290	PDQ	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3878	OCHV	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147098	NDFRT	LOOM
http://stirdf.jst.go.jp/id/200907018421314981	IOBC	LOOM
http://purl.bioontology.org/ontology/RCD/x01RL	RCD	LOOM
http://purl.obolibrary.org/obo/CHEBI_6046	NIFSTD	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU001807	LOINC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0012022	OCHV	LOOM
http://purl.obolibrary.org/obo/NCIT_C428	BERO	LOOM
http://purl.bioontology.org/ontology/MESH/D003981	MESH	LOOM
http://purl.obolibrary.org/obo/CHEBI_4495	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4495	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_4495	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_4495	NIFSTD	LOOM
http://purl.bioontology.org/ontology/SNMI/C-81140	SNMI	LOOM
http://purl.bioontology.org/ontology/LNC/LP14713-9	LOINC	LOOM
http://purl.bioontology.org/ontology/ATC/V03AH01	ATC	LOOM
http://purl.obolibrary.org/obo/OMIT_0005253	OMIT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003981	RH-MESH	LOOM
http://www.co-ode.org/ontologies/galen#Diazoxide	GALEN	LOOM
http://purl.bioontology.org/ontology/ATC/C02DA01	ATC	LOOM