The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

Preferred Name	dapsone
Synonyms	4-aminophenyl sulfone p,p-sulphonylbisbenzamine bis(4-aminophenyl)sulfone 4,4'-Sulfonylbisbenzenamine Bis(p-aminophenyl) sulfone p,p-sulphonylbisbenzenamine dapsone 4,4'-diaminodiphenyl sulfone 4-(4-aminophenylsulfonyl)aniline DIAPHENYLSULFONE 4-[(4-aminobenzene)sulfonyl]aniline p,p'-diaminodiphenyl sulfone 4-(4-aminophenylsulfonyl)benzenamine C12H12N2O2S dapsonum DADPS 4-(4-amino-benzenesulfonyl)-phenylamine dapsona DAPSONE DDS Dapsone 4,4'-sulfonylbisaniline 1,1'-sulfonylbis(4-aminobenzene) p-aminophenyl sulfone 4,4'-sulfonyldianiline Diaphenylsulfone 4,4'-dapsone
ID	http://purl.obolibrary.org/obo/CHEBI_4325
AHFScode	08:16.92
altId	CHEBI:226356
ATCCode	J04BA02 D10AX05
binds	http://purl.obolibrary.org/obo/dinto_3133 http://purl.obolibrary.org/obo/dinto_3132 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_1959 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0938 http://purl.obolibrary.org/obo/dinto_0859 http://purl.obolibrary.org/obo/dinto_2116 http://purl.obolibrary.org/obo/dinto_2047 http://purl.obolibrary.org/obo/dinto_2048
CASRN	80-08-0
DBBrand	aczone
DBname	dapsone
DBSynonym	4,4'-diaminodiphenyl sulphone 4,4'-diaminodiphenyl sulfone 4,4'-diaminodiphenylsulfone 1,1'-sulfonylbis[4-aminobenzene] 4,4'-sulfonylbisbenzeneamine dds, pharmaceutical 4,4'-sulfonyldianiline 4,4'-sulfonyldianilin
Definition	Diphenylsulfone in which the hydrogen atom at the 4 position of each of the phenyl groups is substituted by an amino group. It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy.
has effect	http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000333 http://purl.obolibrary.org/obo/OAE_0000197 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000920 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001433 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000866 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0001209 http://purl.obolibrary.org/obo/OAE_0001336 http://purl.obolibrary.org/obo/OAE_0000336 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0001054
has pharmacological target	http://purl.obolibrary.org/obo/dinto_3133 http://purl.obolibrary.org/obo/dinto_3132
has role	http://purl.obolibrary.org/obo/CHEBI_35441 http://purl.obolibrary.org/obo/CHEBI_35472 http://purl.obolibrary.org/obo/CHEBI_35816 http://purl.obolibrary.org/obo/CHEBI_38068
InChI	InChI=1S/C12H12N2O2S/c13-9-1-5-11(6-2-9)17(15,16)12-7-3-10(14)4-8-12/h1-8H,13-14H2
InChIKey	InChIKey=MQJKPEGWNLWLTK-UHFFFAOYSA-N
induces	http://purl.obolibrary.org/obo/dinto_2058
inhibits	http://purl.obolibrary.org/obo/dinto_3133 http://purl.obolibrary.org/obo/dinto_3132
is metabolised by	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_1959 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0938 http://purl.obolibrary.org/obo/dinto_0859 http://purl.obolibrary.org/obo/dinto_2116 http://purl.obolibrary.org/obo/dinto_2047 http://purl.obolibrary.org/obo/dinto_2048
is substrate of	http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_1959 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0938 http://purl.obolibrary.org/obo/dinto_0859 http://purl.obolibrary.org/obo/dinto_2116 http://purl.obolibrary.org/obo/dinto_2047 http://purl.obolibrary.org/obo/dinto_2048
label	dapsone
may interact with	http://purl.obolibrary.org/obo/CHEBI_156095 http://purl.obolibrary.org/obo/dinto_DB01370 http://purl.obolibrary.org/obo/CHEBI_31794 http://purl.obolibrary.org/obo/dinto_DB00582 http://purl.obolibrary.org/obo/dinto_DB01378 http://purl.obolibrary.org/obo/CHEBI_45367 http://purl.obolibrary.org/obo/dinto_DB00440 http://purl.obolibrary.org/obo/dinto_DB01373 http://purl.obolibrary.org/obo/CHEBI_27999 http://purl.obolibrary.org/obo/CHEBI_28077 http://purl.obolibrary.org/obo/dinto_DB00976
prefixIRI	obo2:CHEBI_4325
prefLabel	dapsone
SMILES	NC1=CC=C(C=C1)S(=O)(=O)C1=CC=C(N)C=C1 Nc1ccc(cc1)S(=O)(=O)c1ccc(N)cc1
Synonym	4-aminophenyl sulfone p,p-sulphonylbisbenzamine bis(4-aminophenyl)sulfone 4,4'-Sulfonylbisbenzenamine Bis(p-aminophenyl) sulfone p,p-sulphonylbisbenzenamine dapsone 4,4'-diaminodiphenyl sulfone 4-(4-aminophenylsulfonyl)aniline DIAPHENYLSULFONE 4-[(4-aminobenzene)sulfonyl]aniline p,p'-diaminodiphenyl sulfone 4-(4-aminophenylsulfonyl)benzenamine C12H12N2O2S dapsonum DADPS 4-(4-amino-benzenesulfonyl)-phenylamine dapsona DAPSONE DDS Dapsone 4,4'-sulfonylbisaniline 1,1'-sulfonylbis(4-aminobenzene) p-aminophenyl sulfone 4,4'-sulfonyldianiline Diaphenylsulfone 4,4'-dapsone
xref	Patent:FR829926 KEGG COMPOUND:C07666 PubChem Substance:46505300 NIST Chemistry WebBook:80-08-0 BindingDB:50029764 CASRN:80-08-0 ChemSpider:2849 National Drug Code Directory:0469-5005-03 Wikipedia:Dapsone ChEBI:4325 Drugs.com:http://www.drugs.com/cdi/dapsone.html RxList:http://www.rxlist.com/cgi/generic/dapsone.htm Drugs Product Database (DPD):2041510 PharmGKB:PA449211 KEGG DRUG:D00592 Beilstein:788055 Wikipedia:http://en.wikipedia.org/wiki/Dapsone PubChem Compound:2955 DrugBank:DB00250
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_4325	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4325	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4325	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4325	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4325	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4325	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4325	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_4325	ODNAE	SAME_URI
http://purl.obolibrary.org/obo/ARO_3003412	ARO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4325	DRON	LOOM
https://github.com/sap218/coid/blob/master/coid.owl#COID_00897	COID	LOOM
http://purl.bioontology.org/ontology/CSP/2840-6854	CRISP	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387096002	SNOMEDCT	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D003622	RH-MESH	LOOM
http://purl.bioontology.org/ontology/PDQ/CDR0000040323	PDQ	LOOM
http://purl.bioontology.org/ontology/NDDF/003003	NDDF	LOOM
http://purl.bioontology.org/ontology/ATC/J04BA02	ATC	LOOM
http://purl.obolibrary.org/obo/MESH_D003622	BERO	LOOM
http://purl.jp/bio/4/id/200906089537092065	IOBC	LOOM
http://purl.bioontology.org/ontology/MESH/D003622	MESH	LOOM
http://www.co-ode.org/ontologies/galen#Dapsone	GALEN	LOOM
http://purl.obolibrary.org/obo/CHEBI_4325	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_4325	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4325	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_4325	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_4325	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_4325	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_4325	ODNAE	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.886.590.263	RH-MESH	LOOM
http://purl.obolibrary.org/obo/ARO_3003412	ARO	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU024811	LOINC	LOOM
http://purl.obolibrary.org/obo/NCIT_C415	BERO	LOOM
http://purl.bioontology.org/ontology/SNMI/C-55292	SNMI	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00017418	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/ATC/D10AX05	ATC	LOOM
http://purl.bioontology.org/ontology/LNC/LP32038-9	LOINC	LOOM
http://purl.obolibrary.org/obo/OMIT_0004905	OMIT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0010980	OCHV	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C415	NCIT	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147467	ODAE	LOOM
http://purl.bioontology.org/ontology/VANDF/4019264	VANDF	LOOM
http://purl.bioontology.org/ontology/RXNORM/3108	RXNORM	LOOM
http://purl.bioontology.org/ontology/LNC/LP17991-8	LOINC	LOOM
https://go.drugbank.com/drugs/DB00250	MDM	LOOM
http://purl.bioontology.org/ontology/RCD/ee1..	RCD	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147467	NDFRT	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3609	OCHV	LOOM