The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	abacavir
Synonyms	[(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl]methanol {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol Abacavir {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol abacavir C14H18N6O
ID	http://purl.obolibrary.org/obo/CHEBI_421707
AHFScode	08:18.08.20
altId	CHEBI:520984 CHEBI:441792 CHEBI:525912 CHEBI:2360 CHEBI:193608
ATCCode	J05AF06
CASRN	136470-78-5
DBBrand	ziagen
DBname	abacavir
Definition	(1S)-Cyclopent-2-en-1-ylmethanol in which the pro-R hydrogen at the 4-position is substituted by a 2-amino-6-(cyclopropylamino)-9H-purin-9-yl group. A nucleoside analogue reverse transcriptase inhibitor (NRTI) with antiretroviral activity against HIV, it is used (particularly as the sulfate) with other antiretrovirals in combination therapy of HIV infection.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000496 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0001373 http://purl.obolibrary.org/obo/OAE_0001154 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000376 http://purl.obolibrary.org/obo/OAE_0000479 http://purl.obolibrary.org/obo/OAE_0000561 http://purl.obolibrary.org/obo/OAE_0001369 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0001370 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0001026 http://purl.obolibrary.org/obo/OAE_0000632 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001190 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000643 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000968 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0001403 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0001147 http://purl.obolibrary.org/obo/OAE_0001052 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000390 http://purl.obolibrary.org/obo/OAE_0000347 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000394 http://purl.obolibrary.org/obo/OAE_0000211 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0000260 http://purl.obolibrary.org/obo/OAE_0000890 http://purl.obolibrary.org/obo/OAE_0001364 http://purl.obolibrary.org/obo/OAE_0000402
has pharmacological target	http://purl.obolibrary.org/obo/dinto_1703
has role	http://purl.obolibrary.org/obo/CHEBI_53756 http://purl.obolibrary.org/obo/CHEBI_36044
InChI	InChI=1S/C14H18N6O/c15-14-18-12(17-9-2-3-9)11-13(19-14)20(7-16-11)10-4-1-8(5-10)6-21/h1,4,7-10,21H,2-3,5-6H2,(H3,15,17,18,19)/t8-,10+/m1/s1
InChIKey	InChIKey=MCGSCOLBFJQGHM-SCZZXKLOSA-N
inhibits	http://purl.obolibrary.org/obo/dinto_1703
label	abacavir
prefixIRI	obo2:CHEBI_421707
prefLabel	abacavir
related with	http://purl.obolibrary.org/obo/dinto_0271 http://purl.obolibrary.org/obo/dinto_0276
SMILES	Nc1nc(NC2CC2)c2ncn([C@@H]3C[C@H](CO)C=C3)c2n1 NC1=NC2=C(N=CN2[C@@H]2C[C@H](CO)C=C2)C(NC2CC2)=N1
Synonym	[(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl]methanol {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol Abacavir {(1S-cis)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methanol abacavir C14H18N6O
xref	RxList:http://www.rxlist.com/cgi/generic/abavir.htm ChEMBL:18029175 CiteXplore:18549801 Drugs Product Database (DPD):2240358 ChEMBL:16759112 Drugs.com:http://www.drugs.com/cdi/abacavir.html KEGG DRUG:D07057 National Drug Code Directory:0173-0661-01 ChemSpider:58649 CASRN:136470-78-5 KEGG COMPOUND:C07624 PDRhealth:http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/cx1527.shtml ChEMBL:12781181 ChEMBL:17870541 PharmGKB:PA448004 PubChem Compound:441300 ChEMBL:15887959 ChEMBL:16458506 ChEBI:2360 Beilstein:7493116 ChEMBL:16539393 ChEMBL:17172311 Wikipedia:Abacavir CiteXplore:11678376 DrugBank:DB01048 PubChem Substance:46505718 Wikipedia:http://en.wikipedia.org/wiki/Abacavir
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_421707	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_421707	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_421707	DOID	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_421707	OBA	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_421707	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_421707	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_421707	HOIP	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_421707	COVID-19	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_421707	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_421707	HUPSON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_421707	HHEAR	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_421707	TXPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_421707	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_421707	GSSO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_421707	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_421707	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_421707	HINO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_421707	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_421707	OBA	LOOM
http://purl.obolibrary.org/obo/CHEBI_421707	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_421707	DOID	LOOM
http://www.semanticweb.org/admin/ontologies/2022/7/MIO:01930	MIO	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0663655	OCHV	LOOM
http://purl.jp/bio/4/id/200906006805211355	IOBC	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/387005008	SNOMEDCT	LOOM
http://www.co-ode.org/ontologies/galen#Abacavir	GALEN	LOOM
http://purl.bioontology.org/ontology/RXNORM/190521	RXNORM	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026002	PMAPP-PMO	LOOM
http://purl.bioontology.org/ontology/VANDF/4024130	VANDF	LOOM
http://purl.bioontology.org/ontology/LNC/LP21306-3	LOINC	LOOM
http://purl.bioontology.org/ontology/NDDF/007687	NDDF	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C106538	RH-MESH	LOOM
https://go.drugbank.com/drugs/DB01048	MDM	LOOM
http://purl.bioontology.org/ontology/ATC/J05AF06	ATC	LOOM
http://purl.obolibrary.org/obo/CHEBI_421707	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_421707	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_421707	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_421707	COVID-19	LOOM
http://purl.obolibrary.org/obo/CHEBI_421707	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_421707	HUPSON	LOOM
http://purl.obolibrary.org/obo/CHEBI_421707	HHEAR	LOOM
http://purl.obolibrary.org/obo/CHEBI_421707	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_421707	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_421707	GSSO	LOOM
http://purl.obolibrary.org/obo/CHEBI_421707	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_421707	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_421707	HINO	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU013841	LOINC	LOOM
http://stirdf.jst.go.jp/id/200907053495805294	IOBC	LOOM
http://purl.obolibrary.org/obo/NCIT_C61523	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_2360	NIFSTD	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61523	NCIT	LOOM
http://purl.bioontology.org/ontology/CSP/5000-0032	CRISP	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#42526	OCHV	LOOM
http://purl.bioontology.org/ontology/MESH/C106538	MESH	LOOM