The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016

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Preferred Name	tamoxifen
Synonyms	trans-Tamoxifen (2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine Crisafeno (Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine 1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene 1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene (Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine Diemon Apo-Tamox tamoxifeno C26H29NO 2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine tamoxifenum tamoxifen tamoxifene Tamoxifen
ID	http://purl.obolibrary.org/obo/CHEBI_41774
activates	http://purl.obolibrary.org/obo/dinto_2830 http://purl.obolibrary.org/obo/dinto_2827
AHFScode	10:00.00
altId	CHEBI:41767 CHEBI:9396
ATCCode	L02BA01
binds	http://purl.obolibrary.org/obo/dinto_3102 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0470 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_0285 http://purl.obolibrary.org/obo/dinto_3489 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0465 http://purl.obolibrary.org/obo/dinto_2830 http://purl.obolibrary.org/obo/dinto_2827 http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_3549 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_0270 http://purl.obolibrary.org/obo/dinto_2048 http://purl.obolibrary.org/obo/dinto_2045 http://purl.obolibrary.org/obo/dinto_0887 http://purl.obolibrary.org/obo/dinto_0883
blocks	http://purl.obolibrary.org/obo/dinto_2830 http://purl.obolibrary.org/obo/dinto_2827
CASRN	10540-29-1
DBBrand	retaxim zemide pms-tamoxifen nourytam tamoxen nolvadex gen-tamoxifen noltam novo-tamoxifen crisafeno tamofen soltamox citofen istubol tamizam oncomox diemon tamone valodex tamoxasta nolvadex-d
DBname	tamoxifen
DBSalt	tamoxifen citrate
DBSynonym	nolvadex tamoxifen citras ici-46474
Definition	A stilbenoid that has formula C26H29NO.
has effect	http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000879 http://purl.obolibrary.org/obo/OAE_0000449 http://purl.obolibrary.org/obo/OAE_0000599 http://purl.obolibrary.org/obo/OAE_0000453 http://purl.obolibrary.org/obo/OAE_0000604 http://purl.obolibrary.org/obo/OAE_0001505 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0001510 http://purl.obolibrary.org/obo/OAE_0001744 http://purl.obolibrary.org/obo/OAE_0000596 http://purl.obolibrary.org/obo/OAE_0000406 http://purl.obolibrary.org/obo/OAE_0000493 http://purl.obolibrary.org/obo/OAE_0000921 http://purl.obolibrary.org/obo/OAE_0000567 http://purl.obolibrary.org/obo/OAE_0000415 http://purl.obolibrary.org/obo/OAE_0000195 http://purl.obolibrary.org/obo/OAE_0000373 http://purl.obolibrary.org/obo/OAE_0000577 http://purl.obolibrary.org/obo/OAE_0000418 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0000319 http://purl.obolibrary.org/obo/OAE_0000021 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000660 http://purl.obolibrary.org/obo/OAE_0001595 http://purl.obolibrary.org/obo/OAE_0000382 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0000310 http://purl.obolibrary.org/obo/OAE_0000050 http://purl.obolibrary.org/obo/OAE_0000403 http://purl.obolibrary.org/obo/OAE_0000861 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0001463 http://purl.obolibrary.org/obo/OAE_0000375 http://purl.obolibrary.org/obo/OAE_0000300 http://purl.obolibrary.org/obo/OAE_0001340 http://purl.obolibrary.org/obo/OAE_0000455 http://purl.obolibrary.org/obo/OAE_0000498 http://purl.obolibrary.org/obo/OAE_0000943 http://purl.obolibrary.org/obo/OAE_0000084 http://purl.obolibrary.org/obo/OAE_0001200 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0001529 http://purl.obolibrary.org/obo/OAE_0000645 http://purl.obolibrary.org/obo/OAE_0000584 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0000643 http://purl.obolibrary.org/obo/OAE_0001153 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000533 http://purl.obolibrary.org/obo/OAE_0000414 http://purl.obolibrary.org/obo/OAE_0001155 http://purl.obolibrary.org/obo/OAE_0000789 http://purl.obolibrary.org/obo/OAE_0000038 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0002122 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000343 http://purl.obolibrary.org/obo/OAE_0000647 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000194 http://purl.obolibrary.org/obo/OAE_0000385 http://purl.obolibrary.org/obo/OAE_0000185 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000487 http://purl.obolibrary.org/obo/OAE_0001052 http://purl.obolibrary.org/obo/OAE_0001217 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000275 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000565 http://purl.obolibrary.org/obo/OAE_0000374 http://purl.obolibrary.org/obo/OAE_0000462 http://purl.obolibrary.org/obo/OAE_0000766 http://purl.obolibrary.org/obo/OAE_0000618 http://purl.obolibrary.org/obo/OAE_0000534 http://purl.obolibrary.org/obo/OAE_0001044 http://purl.obolibrary.org/obo/OAE_0000402 http://purl.obolibrary.org/obo/OAE_0000811 http://purl.obolibrary.org/obo/OAE_0000506
has pharmacological target	http://purl.obolibrary.org/obo/dinto_2830 http://purl.obolibrary.org/obo/dinto_2827
has role	http://purl.obolibrary.org/obo/CHEBI_35610 http://purl.obolibrary.org/obo/CHEBI_50739 http://purl.obolibrary.org/obo/CHEBI_37700 http://purl.obolibrary.org/obo/CHEBI_50646 http://purl.obolibrary.org/obo/CHEBI_50837 http://purl.obolibrary.org/obo/CHEBI_50792 http://purl.obolibrary.org/obo/CHEBI_48422
InChI	InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-
InChIKey	InChIKey=NKANXQFJJICGDU-QPLCGJKRSA-N
induces	http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440
inhibits	http://purl.obolibrary.org/obo/dinto_3102 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_0470 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_1440 http://purl.obolibrary.org/obo/dinto_0285 http://purl.obolibrary.org/obo/dinto_3489 http://purl.obolibrary.org/obo/dinto_1221 http://purl.obolibrary.org/obo/dinto_0465
is metabolised by	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0285 http://purl.obolibrary.org/obo/dinto_3549 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_0270 http://purl.obolibrary.org/obo/dinto_0465 http://purl.obolibrary.org/obo/dinto_2048 http://purl.obolibrary.org/obo/dinto_2045
is substrate of	http://purl.obolibrary.org/obo/dinto_2651 http://purl.obolibrary.org/obo/dinto_2058 http://purl.obolibrary.org/obo/dinto_2990 http://purl.obolibrary.org/obo/dinto_2993 http://purl.obolibrary.org/obo/dinto_0293 http://purl.obolibrary.org/obo/dinto_0291 http://purl.obolibrary.org/obo/dinto_0269 http://purl.obolibrary.org/obo/dinto_0901 http://purl.obolibrary.org/obo/dinto_0285 http://purl.obolibrary.org/obo/dinto_3549 http://purl.obolibrary.org/obo/dinto_2496 http://purl.obolibrary.org/obo/dinto_1956 http://purl.obolibrary.org/obo/dinto_0270 http://purl.obolibrary.org/obo/dinto_0465 http://purl.obolibrary.org/obo/dinto_2048 http://purl.obolibrary.org/obo/dinto_2045 http://purl.obolibrary.org/obo/dinto_0887 http://purl.obolibrary.org/obo/dinto_0883 http://purl.obolibrary.org/obo/dinto_1440
is transported by	http://purl.obolibrary.org/obo/dinto_0887 http://purl.obolibrary.org/obo/dinto_0883 http://purl.obolibrary.org/obo/dinto_1440
label	tamoxifen
modulates	http://purl.obolibrary.org/obo/dinto_2830 http://purl.obolibrary.org/obo/dinto_2827
prefixIRI	obo2:CHEBI_41774
prefLabel	tamoxifen
SMILES	CC\C(=C(/C1=CC=CC=C1)C1=CC=C(OCCN(C)C)C=C1)C1=CC=CC=C1 CC\\C(c1ccccc1)=C(/c1ccccc1)c1ccc(OCCN(C)C)cc1
Synonym	trans-Tamoxifen (2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine Crisafeno (Z)-2-(4-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine 1-p-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene 1-para-beta-Dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene (Z)-2-(para-(1,2-Diphenyl-1-butenyl)phenoxy)-N,N-dimethylamine Diemon Apo-Tamox tamoxifeno C26H29NO 2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}-N,N-dimethylethanamine tamoxifenum tamoxifen tamoxifene Tamoxifen
xref	ChemSpider:2015313 Wikipedia:Tamoxifen Patent:BE637389 ChEBI:9396 DrugBank:DB00675 KEGG DRUG:D08559 CiteXplore:14709804 CASRN:10540-29-1 Guide To Pharmacology:1016 Beilstein:2062020 ChEMBL:106968 Patent:BE678807 Wikipedia:http://en.wikipedia.org/wiki/Tamoxifen IUPHAR:1016 HMDB:HMDB14813 CiteXplore:18348622 Drugs.com:http://www.drugs.com/tamoxifen.html PubChem Compound:2733526 KEGG COMPOUND:C07108 PubChem Substance:46505515 PharmGKB:PA451581 National Drug Code Directory:0378-0144-91 CiteXplore:7688593 Drugs Product Database (DPD):2237460 RxList:http://www.rxlist.com/cgi/generic/tamox.htm PDB:OHT BindingDB:20607 Patent:US4536516
subClassOf	http://purl.obolibrary.org/obo/dinto_000055

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Mapping To	Ontology	Source
http://purl.obolibrary.org/obo/CHEBI_41774	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	PDRO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	FIDEO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	INBANCIDO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	CCONT	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	HOIP	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	COVID-19	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	BERO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	EFO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	DDSS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	TXPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	BIOMODELS	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	CIDO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	CHEBI	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	NIFSTD	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	FYPO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	HINO	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	DRON	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	ODNAE	SAME_URI
http://purl.obolibrary.org/obo/CHEBI_41774	OBA	SAME_URI
http://purl.bioontology.org/ontology/SNMI/C-781E0	SNMI	LOOM
http://purl.bioontology.org/ontology/RXNORM/10324	NLMVS	LOOM
http://purl.bioontology.org/ontology/RXNORM/10324	RXNORM	LOOM
http://www.phoc.org.cn/pmo/class/PMO_00016780	PMAPP-PMO	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D013629	RH-MESH	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	PDRO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	FIDEO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	INBANCIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	CCONT	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	HOIP	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	COVID-19	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	BERO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	EFO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	DDSS	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	TXPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	BIOMODELS	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	CIDO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	CHEBI	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	NIFSTD	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	FYPO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	HINO	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	DRON	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	ODNAE	LOOM
http://purl.obolibrary.org/obo/CHEBI_41774	OBA	LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62078	NCIT	LOOM
http://purl.org/obo/owl/CHEBI#CHEBI_41774	NPO	LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/373345002	SNOMEDCT	LOOM
http://purl.bioontology.org/ontology/NDDF/004826	NDDF	LOOM
http://purl.obolibrary.org/obo/MESH_D013629	BERO	LOOM
http://stirdf.jst.go.jp/id/200907076113483543	IOBC	LOOM
http://purl.bioontology.org/ontology/ATC/L02BA01	ATC	LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0039286	OCHV	LOOM
http://purl.bioontology.org/ontology/LNC/LA14344-8	LOINC	LOOM
http://www.drugbank.ca/drugs/DB00675	FTC	LOOM
http://purl.bioontology.org/ontology/MESH/D013629	MESH	LOOM
http://purl.bioontology.org/ontology/CSP/0119-1179	CRISP	LOOM
http://www.bioontology.org/pma.owl#PMA_1416	PMA	LOOM
http://purl.obolibrary.org/obo/NCIT_C62078	BERO	LOOM
http://www.ifomis.org/acgt/1.0#Tamoxifen	ACGT-MO	LOOM
http://purl.jp/bio/4/id/200906003583642183	IOBC	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148024	INBANCIDO	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148024	ODAE	LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000148024	CIDO	LOOM
http://purl.bioontology.org/ontology/LNC/MTHU003102	LOINC	LOOM
https://go.drugbank.com/drugs/DB00675	MDM	LOOM
rgo:24944	GAMUTS	LOOM
http://purl.obolibrary.org/obo/OMIT_0014488	OMIT	LOOM
http://www.projecthalo.com/aura#Tamoxifen	AURA	LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000148024	NDFRT	LOOM
http://www.semanticweb.org/cjf/ontologies/2022/8/NeuralReprogrammingOntology(NRO)#Tamoxifen	NRO	LOOM
http://www.co-ode.org/ontologies/galen#Tamoxifen	GALEN	LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.455.426.559.389.150.700.900	RH-MESH	LOOM
http://purl.bioontology.org/ontology/LNC/LP18484-3	LOINC	LOOM
http://purl.bioontology.org/ontology/RCD/he4..	RCD	LOOM
http://purl.bioontology.org/ontology/VANDF/4019939	VANDF	LOOM