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The Drug-Drug Interactions Ontology
| Preferred Name | cyproheptadine | |
| Synonyms |
ciproheptadina Cyproheptadine 4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine CYPROHEPTADINE cyproheptadinum C21H21N 4-Dibenzo[a,d]cyclohepten-5-ylidene-1-methyl-piperidine 4-(5-dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine 1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine 5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine 1-methyl-4-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-2-ylidene}piperidine 1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine cyproheptadine 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_4046 |
|
| AHFScode |
04:04.92
|
|
| altId |
CHEBI:111005 CHEBI:605605
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|
| ATCCode |
R06AX02
|
|
| binds |
http://purl.obolibrary.org/obo/dinto_0510 http://purl.obolibrary.org/obo/dinto_1071 http://purl.obolibrary.org/obo/dinto_0392 http://purl.obolibrary.org/obo/dinto_3182 http://purl.obolibrary.org/obo/dinto_1005 |
|
| blocks |
http://purl.obolibrary.org/obo/dinto_3182 http://purl.obolibrary.org/obo/dinto_0510 http://purl.obolibrary.org/obo/dinto_1005 http://purl.obolibrary.org/obo/dinto_3887 |
|
| CASRN |
129-03-3
|
|
| DBBrand |
periactinol peritol cyproheptadiene cyproheptadine hcl cypoheptadine eiproheptadine dronactin periactin dibenzosuberonone/cyproheptadine periactine
|
|
| DBname |
cyproheptadine
|
|
| Definition |
The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.
|
|
| has effect |
http://purl.obolibrary.org/obo/OAE_0000388 http://purl.obolibrary.org/obo/OAE_0000377 http://purl.obolibrary.org/obo/OAE_0000335 http://purl.obolibrary.org/obo/OAE_0001509 http://purl.obolibrary.org/obo/OAE_0000512 http://purl.obolibrary.org/obo/OAE_0001489 http://purl.obolibrary.org/obo/OAE_0000210 http://purl.obolibrary.org/obo/OAE_0001448 http://purl.obolibrary.org/obo/OAE_0000365 http://purl.obolibrary.org/obo/OAE_0000600 http://purl.obolibrary.org/obo/OAE_0001026 http://purl.obolibrary.org/obo/OAE_0000601 http://purl.obolibrary.org/obo/OAE_0000551 http://purl.obolibrary.org/obo/OAE_0001105 http://purl.obolibrary.org/obo/OAE_0001515 http://purl.obolibrary.org/obo/OAE_0000268 http://purl.obolibrary.org/obo/OAE_0000400 http://purl.obolibrary.org/obo/OAE_0001129 http://purl.obolibrary.org/obo/OAE_0002206 http://purl.obolibrary.org/obo/OAE_0000607 http://purl.obolibrary.org/obo/OAE_0000355 http://purl.obolibrary.org/obo/OAE_0000034 http://purl.obolibrary.org/obo/OAE_0000166 http://purl.obolibrary.org/obo/OAE_0000460 http://purl.obolibrary.org/obo/OAE_0000401 http://purl.obolibrary.org/obo/OAE_0000505 http://purl.obolibrary.org/obo/OAE_0000306 http://purl.obolibrary.org/obo/OAE_0000468 http://purl.obolibrary.org/obo/OAE_0000602 http://purl.obolibrary.org/obo/OAE_0000396 http://purl.obolibrary.org/obo/OAE_0000362 http://purl.obolibrary.org/obo/OAE_0000394 |
|
| has pharmacological target |
http://purl.obolibrary.org/obo/dinto_0510 |
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_37955 http://purl.obolibrary.org/obo/CHEBI_55324 http://purl.obolibrary.org/obo/CHEBI_48279 |
|
| InChI |
InChI=1S/C21H21N/c1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21/h2-11H,12-15H2,1H3
|
|
| InChIKey |
InChIKey=JJCFRYNCJDLXIK-UHFFFAOYSA-N
|
|
| is metabolised by | ||
| is substrate of | ||
| label |
cyproheptadine
|
|
| may interact with |
http://purl.obolibrary.org/obo/CHEBI_42944 http://purl.obolibrary.org/obo/dinto_DB00209 http://purl.obolibrary.org/obo/CHEBI_8874 http://purl.obolibrary.org/obo/CHEBI_53289 http://purl.obolibrary.org/obo/dinto_DB01011 http://purl.obolibrary.org/obo/dinto_DB00427 |
|
| modulates |
http://purl.obolibrary.org/obo/dinto_3182 http://purl.obolibrary.org/obo/dinto_0510 http://purl.obolibrary.org/obo/dinto_1005 http://purl.obolibrary.org/obo/dinto_3887 |
|
| prefixIRI |
obo2:CHEBI_4046
|
|
| prefLabel |
cyproheptadine
|
|
| SMILES |
CN1CCC(CC1)=C1C2=CC=CC=C2C=CC2=CC=CC=C12 CN1CCC(CC1)=C1c2ccccc2C=Cc2ccccc12
|
|
| Synonym |
ciproheptadina Cyproheptadine 4-(5H-dibenzo[a,d][7]annulen-5-ylidene)-1-methylpiperidine CYPROHEPTADINE cyproheptadinum C21H21N 4-Dibenzo[a,d]cyclohepten-5-ylidene-1-methyl-piperidine 4-(5-dibenzo(a,d)cyclohepten-5-ylidine)-1-methylpiperidine 1-Methyl-4-(5H-dibenzo(a,d)cycloheptenylidene)piperidine 5-(1-methylpiperidylidene-4)-5H-dibenzo(a,d)cyclopheptene 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methylpiperidine 1-methyl-4-{tricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-2-ylidene}piperidine 1-methyl-4-(5-dibenzo(a,e)cycloheptatrienylidene)piperidine cyproheptadine 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-methylpiperidine
|
|
| xref |
RxList:http://www.rxlist.com/cgi/generic2/cyprohept.htm Guide To Pharmacology:277 ChEBI:4046 Wikipedia:http://en.wikipedia.org/wiki/Cyproheptadine Patent:US3014911 National Drug Code Directory:49884-043-01 ChEMBL:10843226 BindingDB:50017721 CASRN:129-03-3 Wikipedia:Cyproheptadine Drugs Product Database (DPD):2245668 KEGG DRUG:D07765 NIST Chemistry WebBook:129-03-3 PharmGKB:PA164749366 PubChem Compound:2913 IUPHAR:277 PubChem Substance:46508613 Beilstein:1348386 KEGG COMPOUND:C06935 ChemSpider:2810 Drugs.com:http://www.drugs.com/cdi/cyproheptadine.html DrugBank:DB00434
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| subClassOf |
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