The Drug-Drug Interactions Ontology

Last uploaded: February 11, 2016
Preferred Name

clemastine
Synonyms

(2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine

clemastinum

clemastine

clemastina

(+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrrolidine

(+)-(2R)-2-[2-[[(R)-p-chloro-alpha-methyl-alpha-phenylbenzyl]oxy]ethyl]-1-methylpyrrolidine

C21H26ClNO

Clemastine

ID

http://purl.obolibrary.org/obo/CHEBI_3738

AHFScode

04:04.04

altId

CHEBI:569763

ATCCode

R06AA04

D04AA14

binds

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0901

http://purl.obolibrary.org/obo/dinto_1071

blocks

http://purl.obolibrary.org/obo/dinto_1071

CASRN

15686-51-8

DBBrand

tavist

tavist-1

mecloprodin

meclastin

DBname

clemastine

DBSynonym

clemastinum [inn-latin]

clemastine fumarate

clemastina [inn-spanish]

Definition

2-[(2R)-1-Methylpyrrolidin-2-yl]ethanol in which the hydrogen of the hydroxy group is substituted by a 1-(4-chlorophenyl)-1-phenylethyl group (R configuration). An antihistamine with antimuscarinic and moderate sedative properties, it is used as its fumarate salt for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin conditions.

has effect

http://purl.obolibrary.org/obo/OAE_0000388

http://purl.obolibrary.org/obo/OAE_0000377

http://purl.obolibrary.org/obo/OAE_0000335

http://purl.obolibrary.org/obo/OAE_0001509

http://purl.obolibrary.org/obo/OAE_0001489

http://purl.obolibrary.org/obo/OAE_0001448

http://purl.obolibrary.org/obo/OAE_0000365

http://purl.obolibrary.org/obo/OAE_0000600

http://purl.obolibrary.org/obo/OAE_0000601

http://purl.obolibrary.org/obo/OAE_0000551

http://purl.obolibrary.org/obo/OAE_0001105

http://purl.obolibrary.org/obo/OAE_0000268

http://purl.obolibrary.org/obo/OAE_0002206

http://purl.obolibrary.org/obo/OAE_0000607

http://purl.obolibrary.org/obo/OAE_0000355

http://purl.obolibrary.org/obo/OAE_0000034

http://purl.obolibrary.org/obo/OAE_0000166

http://purl.obolibrary.org/obo/OAE_0000460

http://purl.obolibrary.org/obo/OAE_0000401

http://purl.obolibrary.org/obo/OAE_0000505

http://purl.obolibrary.org/obo/OAE_0000306

http://purl.obolibrary.org/obo/OAE_0000602

http://purl.obolibrary.org/obo/OAE_0000396

http://purl.obolibrary.org/obo/OAE_0000362

http://purl.obolibrary.org/obo/OAE_0000394

http://purl.obolibrary.org/obo/OAE_0001309

has pharmacological target

http://purl.obolibrary.org/obo/dinto_1071

has role

http://purl.obolibrary.org/obo/CHEBI_37955

http://purl.obolibrary.org/obo/CHEBI_48876

http://purl.obolibrary.org/obo/CHEBI_59683

http://purl.obolibrary.org/obo/CHEBI_50857

InChI

InChI=1S/C21H26ClNO/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3/t20-,21-/m1/s1

InChIKey

InChIKey=YNNUSGIPVFPVBX-NHCUHLMSSA-N

inhibits

http://purl.obolibrary.org/obo/dinto_2993

http://purl.obolibrary.org/obo/dinto_0901

label

clemastine

may interact with

http://purl.obolibrary.org/obo/CHEBI_42944

http://purl.obolibrary.org/obo/dinto_DB00209

http://purl.obolibrary.org/obo/CHEBI_8874

http://purl.obolibrary.org/obo/CHEBI_53289

http://purl.obolibrary.org/obo/dinto_DB00427

http://purl.obolibrary.org/obo/CHEBI_27796

http://purl.obolibrary.org/obo/dinto_DB00382

modulates

http://purl.obolibrary.org/obo/dinto_1071

prefixIRI

obo2:CHEBI_3738

prefLabel

clemastine

SMILES

[H][C@@]1(CCCN1C)CCO[C@](C)(c1ccccc1)c1ccc(Cl)cc1

CN1CCC[C@@H]1CCO[C@](C)(C1=CC=CC=C1)C1=CC=C(Cl)C=C1

Synonym

(2R)-2-{2-[(1R)-1-(4-chlorophenyl)-1-phenylethoxy]ethyl}-1-methylpyrrolidine

clemastinum

clemastine

clemastina

(+)-(2R)-2-(2-(((R)-p-chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methylpyrrolidine

(+)-(2R)-2-[2-[[(R)-p-chloro-alpha-methyl-alpha-phenylbenzyl]oxy]ethyl]-1-methylpyrrolidine

C21H26ClNO

Clemastine

xref

Beilstein:6486432

DrugBank:DB00283

Patent:GB942152

KEGG COMPOUND:C06913

NIST Chemistry WebBook:15686-51-8

KEGG DRUG:D03535

RxList:http://www.rxlist.com/cgi/generic3/clemast.htm

PubChem Compound:26987

ChEMBL:18788725

PharmGKB:PA164776997

Drugs Product Database (DPD):35971

Wikipedia:http://en.wikipedia.org/wiki/Clemastine

CASRN:15686-51-8

Wikipedia:Clemastine

ChEBI:3738

ChemSpider:25129

National Drug Code Directory:0781-1359-01

BindingDB:50253157

PubChem Substance:46506492

Drugs.com:http://www.drugs.com/cdi/clemastine.html

subClassOf

http://purl.obolibrary.org/obo/dinto_000055

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Mapping To Ontology Source
http://purl.obolibrary.org/obo/CHEBI_3738 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3738 DRON SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3738 PDRO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3738 FIDEO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3738 CHEBI SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3738 BERO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3738 DDSS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3738 BIOMODELS SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3738 CIDO SAME_URI
http://purl.obolibrary.org/obo/CHEBI_3738 DRON LOOM
http://www.co-ode.org/ontologies/galen#Clemastine GALEN LOOM
http://purl.obolibrary.org/obo/NCIT_C61682 BERO LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372744005 SNOMEDCT LOOM
https://go.drugbank.com/drugs/DB00283 MDM LOOM
http://purl.bioontology.org/ontology/ATC/R06AA04 ATC LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61682 NCIT LOOM
http://purl.bioontology.org/ontology/RXNORM/2578 RXNORM LOOM
http://purl.bioontology.org/ontology/NDDF/004441 NDDF LOOM
http://purl.obolibrary.org/obo/MESH_D002974 BERO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0008929 OCHV LOOM
http://purl.obolibrary.org/obo/OMIT_0004289 OMIT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D03.383.773.165 RH-MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00018472 PMAPP-PMO LOOM
http://purl.obolibrary.org/obo/CHEBI_3738 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_3738 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_3738 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_3738 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3738 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_3738 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_3738 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3738 CIDO LOOM
http://purl.bioontology.org/ontology/ATC/D04AA14 ATC LOOM
http://www.drugbank.ca/drugs/DB00283 FTC LOOM
http://purl.bioontology.org/ontology/RCD/c85.. RCD LOOM
http://purl.bioontology.org/ontology/SNMI/C-51440 SNMI LOOM
http://purl.jp/bio/4/id/200906088282953430 IOBC LOOM
http://purl.bioontology.org/ontology/VANDF/4019681 VANDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#3029 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D002974 RH-MESH LOOM
http://purl.bioontology.org/ontology/MESH/D002974 MESH LOOM
http://stirdf.jst.go.jp/id/200907023463507783 IOBC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147773 NDFRT LOOM